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Q5GAM8

- RNS12_MOUSE

UniProt

Q5GAM8 - RNS12_MOUSE

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Protein

Probable inactive ribonuclease-like protein 12

Gene

Rnase12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Does not exhibit any ribonuclease activity.Curated

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive ribonuclease-like protein 12
Gene namesi
Name:Rnase12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:3528588. Rnase12.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 145126Probable inactive ribonuclease-like protein 12PRO_0000308703Add
BLAST

Proteomic databases

PRIDEiQ5GAM8.

Expressioni

Gene expression databases

CleanExiMM_RNASE12.
ExpressionAtlasiQ5GAM8. baseline.
GenevestigatoriQ5GAM8.

Structurei

3D structure databases

ProteinModelPortaliQ5GAM8.
SMRiQ5GAM8. Positions 43-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78149.
HOGENOMiHOG000154174.
HOVERGENiHBG097014.
InParanoidiQ5GAM8.
OMAiGTRYPAC.
OrthoDBiEOG725DKJ.
PhylomeDBiQ5GAM8.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5GAM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ
60 70 80 90 100
RVIREPDHRC RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK
110 120 130 140
FRMTVCQLID GTTYPACRYQ ISPIKGFVLV TCDDLGPVDL QGYVE
Length:145
Mass (Da):16,936
Last modified:March 1, 2005 - v1
Checksum:i723032269725AD05
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
CCDSiCCDS27032.1.
RefSeqiNP_001011875.1. NM_001011875.2.
UniGeneiMm.379740.

Genome annotation databases

EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneIDi497106.
KEGGimmu:497106.
UCSCiuc007tmj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1 .
BC146014 mRNA. Translation: AAI46015.1 .
BC146016 mRNA. Translation: AAI46017.1 .
CCDSi CCDS27032.1.
RefSeqi NP_001011875.1. NM_001011875.2.
UniGenei Mm.379740.

3D structure databases

ProteinModelPortali Q5GAM8.
SMRi Q5GAM8. Positions 43-133.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5GAM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089798 ; ENSMUSP00000087231 ; ENSMUSG00000068407 .
GeneIDi 497106.
KEGGi mmu:497106.
UCSCi uc007tmj.1. mouse.

Organism-specific databases

CTDi 493901.
MGIi MGI:3528588. Rnase12.

Phylogenomic databases

eggNOGi NOG78149.
HOGENOMi HOG000154174.
HOVERGENi HBG097014.
InParanoidi Q5GAM8.
OMAi GTRYPAC.
OrthoDBi EOG725DKJ.
PhylomeDBi Q5GAM8.
TreeFami TF333393.

Miscellaneous databases

NextBioi 411788.
PROi Q5GAM8.
SOURCEi Search...

Gene expression databases

CleanExi MM_RNASE12.
ExpressionAtlasi Q5GAM8. baseline.
Genevestigatori Q5GAM8.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54076. SSF54076. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
    Cho S., Beintema J.J., Zhang J.
    Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRNS12_MOUSE
AccessioniPrimary (citable) accession number: Q5GAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3