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Protein

Probable inactive ribonuclease-like protein 12

Gene

Rnase12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Does not exhibit any ribonuclease activity.Curated

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive ribonuclease-like protein 12
Gene namesi
Name:Rnase12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3528588. Rnase12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030870320 – 145Probable inactive ribonuclease-like protein 12Add BLAST126

Proteomic databases

PaxDbiQ5GAM8.
PRIDEiQ5GAM8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068407.
CleanExiMM_RNASE12.
ExpressionAtlasiQ5GAM8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5GAM8.
SMRiQ5GAM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY9P. Eukaryota.
ENOG4111CPC. LUCA.
GeneTreeiENSGT00730000111478.
HOGENOMiHOG000154174.
HOVERGENiHBG097014.
InParanoidiQ5GAM8.
OMAiHVFIHER.
OrthoDBiEOG091G15X3.
PhylomeDBiQ5GAM8.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5GAM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ
60 70 80 90 100
RVIREPDHRC RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK
110 120 130 140
FRMTVCQLID GTTYPACRYQ ISPIKGFVLV TCDDLGPVDL QGYVE
Length:145
Mass (Da):16,936
Last modified:March 1, 2005 - v1
Checksum:i723032269725AD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
CCDSiCCDS27032.1.
RefSeqiNP_001011875.1. NM_001011875.2.
UniGeneiMm.379740.

Genome annotation databases

EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneIDi497106.
KEGGimmu:497106.
UCSCiuc007tmj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
CCDSiCCDS27032.1.
RefSeqiNP_001011875.1. NM_001011875.2.
UniGeneiMm.379740.

3D structure databases

ProteinModelPortaliQ5GAM8.
SMRiQ5GAM8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5GAM8.
PRIDEiQ5GAM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneIDi497106.
KEGGimmu:497106.
UCSCiuc007tmj.2. mouse.

Organism-specific databases

CTDi493901.
MGIiMGI:3528588. Rnase12.

Phylogenomic databases

eggNOGiENOG410IY9P. Eukaryota.
ENOG4111CPC. LUCA.
GeneTreeiENSGT00730000111478.
HOGENOMiHOG000154174.
HOVERGENiHBG097014.
InParanoidiQ5GAM8.
OMAiHVFIHER.
OrthoDBiEOG091G15X3.
PhylomeDBiQ5GAM8.
TreeFamiTF333393.

Miscellaneous databases

PROiQ5GAM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068407.
CleanExiMM_RNASE12.
ExpressionAtlasiQ5GAM8. baseline and differential.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNS12_MOUSE
AccessioniPrimary (citable) accession number: Q5GAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.