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Protein

Probable inactive ribonuclease-like protein 12

Gene

Rnase12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Does not exhibit any ribonuclease activity.Curated

GO - Molecular functioni

  1. endonuclease activity Source: GO_Central
  2. nucleic acid binding Source: InterPro
  3. ribonuclease activity Source: GO_Central

GO - Biological processi

  1. nucleic acid phosphodiester bond hydrolysis Source: GOC
  2. RNA phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive ribonuclease-like protein 12
Gene namesi
Name:Rnase12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3528588. Rnase12.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 145126Probable inactive ribonuclease-like protein 12PRO_0000308703Add
BLAST

Proteomic databases

PRIDEiQ5GAM8.

Expressioni

Gene expression databases

CleanExiMM_RNASE12.
ExpressionAtlasiQ5GAM8. baseline.
GenevestigatoriQ5GAM8.

Structurei

3D structure databases

SMRiQ5GAM8. Positions 43-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG78149.
HOGENOMiHOG000154174.
HOVERGENiHBG097014.
InParanoidiQ5GAM8.
OMAiGTRYPAC.
OrthoDBiEOG725DKJ.
PhylomeDBiQ5GAM8.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54076. SSF54076. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5GAM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ
60 70 80 90 100
RVIREPDHRC RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK
110 120 130 140
FRMTVCQLID GTTYPACRYQ ISPIKGFVLV TCDDLGPVDL QGYVE
Length:145
Mass (Da):16,936
Last modified:March 1, 2005 - v1
Checksum:i723032269725AD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
CCDSiCCDS27032.1.
RefSeqiNP_001011875.1. NM_001011875.2.
UniGeneiMm.379740.

Genome annotation databases

EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneIDi497106.
KEGGimmu:497106.
UCSCiuc007tmj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
CCDSiCCDS27032.1.
RefSeqiNP_001011875.1. NM_001011875.2.
UniGeneiMm.379740.

3D structure databases

SMRiQ5GAM8. Positions 43-133.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5GAM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneIDi497106.
KEGGimmu:497106.
UCSCiuc007tmj.1. mouse.

Organism-specific databases

CTDi493901.
MGIiMGI:3528588. Rnase12.

Phylogenomic databases

eggNOGiNOG78149.
HOGENOMiHOG000154174.
HOVERGENiHBG097014.
InParanoidiQ5GAM8.
OMAiGTRYPAC.
OrthoDBiEOG725DKJ.
PhylomeDBiQ5GAM8.
TreeFamiTF333393.

Miscellaneous databases

NextBioi411788.
PROiQ5GAM8.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RNASE12.
ExpressionAtlasiQ5GAM8. baseline.
GenevestigatoriQ5GAM8.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR029740. RNASE12.
IPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PTHR11437:SF20. PTHR11437:SF20. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54076. SSF54076. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
    Cho S., Beintema J.J., Zhang J.
    Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRNS12_MOUSE
AccessioniPrimary (citable) accession number: Q5GAM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2005
Last modified: April 29, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.