Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5GAM8 (RNS12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inactive ribonuclease-like protein 12
Gene names
Name:Rnase12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Does not exhibit any ribonuclease activity Potential.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionendoribonuclease activity, producing 3'-phosphomonoesters

Inferred from electronic annotation. Source: InterPro

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 145126Probable inactive ribonuclease-like protein 12
PRO_0000308703

Sequences

Sequence LengthMass (Da)Tools
Q5GAM8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 723032269725AD05

FASTA14516,936
        10         20         30         40         50         60 
MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ RVIREPDHRC 

        70         80         90        100        110        120 
RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK FRMTVCQLID GTTYPACRYQ 

       130        140 
ISPIKGFVLV TCDDLGPVDL QGYVE 

« Hide

References

« Hide 'large scale' references
[1]"The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
Cho S., Beintema J.J., Zhang J.
Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY665824 Genomic DNA. Translation: AAV87191.1.
BC146014 mRNA. Translation: AAI46015.1.
BC146016 mRNA. Translation: AAI46017.1.
RefSeqNP_001011875.1. NM_001011875.2.
UniGeneMm.379740.

3D structure databases

ProteinModelPortalQ5GAM8.
SMRQ5GAM8. Positions 43-133.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5GAM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneID497106.
KEGGmmu:497106.
UCSCuc007tmj.1. mouse.

Organism-specific databases

CTD493901.
MGIMGI:3528588. Rnase12.

Phylogenomic databases

eggNOGNOG78149.
HOGENOMHOG000154174.
HOVERGENHBG097014.
InParanoidQ5GAM8.
OMAGTRYPAC.
OrthoDBEOG725DKJ.
PhylomeDBQ5GAM8.
TreeFamTF333393.

Gene expression databases

CleanExMM_RNASE12.
GenevestigatorQ5GAM8.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF54076. SSF54076. 1 hit.
ProtoNetSearch...

Other

NextBio411788.
PROQ5GAM8.
SOURCESearch...

Entry information

Entry nameRNS12_MOUSE
AccessionPrimary (citable) accession number: Q5GAM8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot