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Q5GAM8

- RNS12_MOUSE

UniProt

Q5GAM8 - RNS12_MOUSE

Protein

Probable inactive ribonuclease-like protein 12

Gene

Rnase12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Does not exhibit any ribonuclease activity.Curated

    GO - Molecular functioni

    1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
    2. nucleic acid binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable inactive ribonuclease-like protein 12
    Gene namesi
    Name:Rnase12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:3528588. Rnase12.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 145126Probable inactive ribonuclease-like protein 12PRO_0000308703Add
    BLAST

    Proteomic databases

    PRIDEiQ5GAM8.

    Expressioni

    Gene expression databases

    CleanExiMM_RNASE12.
    GenevestigatoriQ5GAM8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5GAM8.
    SMRiQ5GAM8. Positions 43-133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pancreatic ribonuclease family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG78149.
    HOGENOMiHOG000154174.
    HOVERGENiHBG097014.
    InParanoidiQ5GAM8.
    OMAiGTRYPAC.
    OrthoDBiEOG725DKJ.
    PhylomeDBiQ5GAM8.
    TreeFamiTF333393.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54076. SSF54076. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5GAM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ    50
    RVIREPDHRC RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK 100
    FRMTVCQLID GTTYPACRYQ ISPIKGFVLV TCDDLGPVDL QGYVE 145
    Length:145
    Mass (Da):16,936
    Last modified:March 1, 2005 - v1
    Checksum:i723032269725AD05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665824 Genomic DNA. Translation: AAV87191.1.
    BC146014 mRNA. Translation: AAI46015.1.
    BC146016 mRNA. Translation: AAI46017.1.
    CCDSiCCDS27032.1.
    RefSeqiNP_001011875.1. NM_001011875.2.
    UniGeneiMm.379740.

    Genome annotation databases

    EnsembliENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
    GeneIDi497106.
    KEGGimmu:497106.
    UCSCiuc007tmj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665824 Genomic DNA. Translation: AAV87191.1 .
    BC146014 mRNA. Translation: AAI46015.1 .
    BC146016 mRNA. Translation: AAI46017.1 .
    CCDSi CCDS27032.1.
    RefSeqi NP_001011875.1. NM_001011875.2.
    UniGenei Mm.379740.

    3D structure databases

    ProteinModelPortali Q5GAM8.
    SMRi Q5GAM8. Positions 43-133.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5GAM8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089798 ; ENSMUSP00000087231 ; ENSMUSG00000068407 .
    GeneIDi 497106.
    KEGGi mmu:497106.
    UCSCi uc007tmj.1. mouse.

    Organism-specific databases

    CTDi 493901.
    MGIi MGI:3528588. Rnase12.

    Phylogenomic databases

    eggNOGi NOG78149.
    HOGENOMi HOG000154174.
    HOVERGENi HBG097014.
    InParanoidi Q5GAM8.
    OMAi GTRYPAC.
    OrthoDBi EOG725DKJ.
    PhylomeDBi Q5GAM8.
    TreeFami TF333393.

    Miscellaneous databases

    NextBioi 411788.
    PROi Q5GAM8.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_RNASE12.
    Genevestigatori Q5GAM8.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories."
      Cho S., Beintema J.J., Zhang J.
      Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRNS12_MOUSE
    AccessioniPrimary (citable) accession number: Q5GAM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3