Q5GAM8 (RNS12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inactive ribonuclease-like protein 12

Gene names

Name:

Rnase12

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Does not exhibit any ribonuclease activity Potential.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the pancreatic ribonuclease family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro pancreatic ribonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 145	126	Probable inactive ribonuclease-like protein 12		PRO_0000308703

Sequences

	Sequence		Length	Mass (Da)
	Q5GAM8 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 723032269725AD05	FASTA	145	16,936
	10 20 30 40 50 60 MVLMVVVFLL LLFWENELTE DVVLTSIEQL HVDYPQNAVP LRYCNYMILQ RVIREPDHRC 70 80 90 100 110 120 RKVHVFIHER PQKINRVCTS SKKMSCPNDS DLFCFQSETK FRMTVCQLID GTTYPACRYQ 130 140 ISPIKGFVLV TCDDLGPVDL QGYVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories." Cho S., Beintema J.J., Zhang J. Genomics 85:208-220(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY665824 Genomic DNA. Translation: AAV87191.1. BC146014 mRNA. Translation: AAI46015.1. BC146016 mRNA. Translation: AAI46017.1.
IPI	IPI00553524.
RefSeq	NP_001011875.1. NM_001011875.2.
UniGene	Mm.379740.
3D structure databases
HSSP	HSSP built from PDB template 1DZA based on UniProtKB P07998.
ProteinModelPortal	Q5GAM8.
SMR	Q5GAM8. Positions 43-133.
ModBase	Search...
Proteomic databases
PRIDE	Q5GAM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000089798; ENSMUSP00000087231; ENSMUSG00000068407.
GeneID	497106.
KEGG	mmu:497106.
UCSC	uc007tmj.1. mouse.
Organism-specific databases
CTD	493901.
MGI	MGI:3528588. Rnase12.
Phylogenomic databases
eggNOG	NOG78149.
GeneTree	ENSGT00530000064075.
HOGENOM	HOG000154174.
HOVERGEN	HBG097014.
InParanoid	Q5GAM8.
OMA	GTRYPAC.
OrthoDB	EOG4DBTG3.
Gene expression databases
CleanEx	MM_RNASE12.
Genevestigator	Q5GAM8.
Family and domain databases
Gene3D	3.10.130.10. 1 hit.
InterPro	IPR001427. RNaseA. IPR023412. RNaseA_domain. [Graphical view]
PANTHER	PTHR11437. PTHR11437. 1 hit.
Pfam	PF00074. RnaseA. 1 hit. [Graphical view]
PRINTS	PR00794. RIBONUCLEASE.
ProDom	PD000535. RNaseA. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54076. RNaseA. 1 hit.
ProtoNet	Search...
Other
NextBio	411788.
SOURCE	Search...

Entry information

Entry name

RNS12_MOUSE

Accession

Primary (citable) accession number: Q5GAM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program