Q5G8B6 (KAX45_TITCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 4.5
Organism	Tityus costatus (Brazilian scorpion)
Taxonomic identifier	309814 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	59 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks voltage-gated potassium channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 4 subfamily.
Mass spectrometry	Molecular mass is 3986 Da from positions 23 - 59. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22
	Chain	23 – 59	37	Potassium channel toxin alpha-KTx 4.5		PRO_0000231505
Regions
	Region	48 – 55	8	Interaction with Ca(2+)-activated K(+) channels Potential
Sites
	Site	49	1	Basic residue of the functional dyad By similarity
	Site	58	1	Aromatic residue of the functional dyad By similarity
Amino acid modifications
	Disulfide bond	29 ↔ 50		By similarity
	Disulfide bond	35 ↔ 55		By similarity
	Disulfide bond	39 ↔ 57		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5G8B6 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 6FC51DBA878CCC2B	FASTA	59	6,518
	10 20 30 40 50 MKAFYGVLII FILISMLDLS QQVFINVKCR GSPECLPKCK EAIGKSAGKC MNGKCKCYP

References

[1]

"The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function." Diego-Garcia E., Batista C.V.F., Garcia-Gomez B.I., Lucas S., Candido D.M., Gomez-Lagunas F., Possani L.D. Toxicon 45:273-283(2005) [PubMed: 15683865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY740685 mRNA. Translation: AAW72455.1.
3D structure databases
ProteinModelPortal	Q5G8B6.
SMR	Q5G8B6. Positions 23-59.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX45_TITCO

Accession

Primary (citable) accession number: Q5G8B6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2005
Last modified:	November 16, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program