Q5G863 (DEF1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neutrophil defensin 1

Alternative name(s):
Defensin, alpha 1

Gene names

Name:

DEFA1

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane By similarity.
Subunit structure	Dimer By similarity.
Subcellular location	Secreted.
Post-translational modification	ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production By similarity.
Sequence similarities	Belongs to the alpha-defensin family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin Fungicide
PTM	ADP-ribosylation Disulfide bond Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of other organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Propeptide	20 – 64	45	By similarity		PRO_0000006775
	Peptide	65 – 94	30	Neutrophil defensin 1		PRO_0000006776
Amino acid modifications
	Modified residue	78	1	ADP-ribosylarginine; by ART1 By similarity
	Modified residue	85	1	Phosphotyrosine By similarity
	Modified residue	88	1	ADP-ribosylarginine; by ART1 By similarity
	Disulfide bond	66 ↔ 94		By similarity
	Disulfide bond	68 ↔ 83		By similarity
	Disulfide bond	73 ↔ 93		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5G863 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: EF49989564D4391B	FASTA	94	10,196
	10 20 30 40 50 60 MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIPADN PEVVVSLAWD ESLAPKHPGS 70 80 90 RKNVACYCRI PACLAGERRY GTCIYQGRLW AFCC

References

[1]	"Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes." Patil A., Hughes A.L., Zhang G. Physiol. Genomics 20:1-11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY746437 mRNA. Translation: AAW78340.1.
RefSeq	XP_003951262.1. XM_003951213.1.
UniGene	Ptr.6231.
3D structure databases
ProteinModelPortal	Q5G863.
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000054978.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	742808.
KEGG	ptr:742808.
Organism-specific databases
CTD	1667.
Phylogenomic databases
eggNOG	NOG86943.
HOGENOM	HOG000233351.
HOVERGEN	HBG011703.
InParanoid	Q5G863.
KO	K05230.
Family and domain databases
InterPro	IPR016327. Alpha-defensin. IPR006080. Defensin_beta/neutrophil. IPR002366. Defensin_propep. IPR006081. Mammalian_defensins. [Graphical view]
Pfam	PF00323. Defensin_1. 1 hit. PF00879. Defensin_propep. 1 hit. [Graphical view]
PIRSF	PIRSF001875. Alpha-defensin. 1 hit.
SMART	SM00048. DEFSN. 1 hit. [Graphical view]
PROSITE	PS00269. DEFENSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20909855.

Entry information

Entry name

DEF1_PANTR

Accession

Primary (citable) accession number: Q5G863

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program