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Protein

Defensin-5

Gene

DEFA5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-5
Alternative name(s):
Defensin, alpha 5
HD5(20-94)
Cleaved into the following 4 chains:
Gene namesi
Name:DEFA5
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Peptidei20 – 9475Defensin-5PRO_0000006789Add
BLAST
Peptidei23 – 9472HD5(23-94)By similarityPRO_0000417391Add
BLAST
Peptidei29 – 9466HD5(29-94)By similarityPRO_0000417392Add
BLAST
Peptidei56 – 9439HD5(56-94)By similarityPRO_0000417393Add
BLAST
Peptidei63 – 9432HD5(63-94)By similarityPRO_0000417394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5G861.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000034189.

Structurei

3D structure databases

ProteinModelPortaliQ5G861.
SMRiQ5G861. Positions 63-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ5G861.
KOiK05230.
OMAiEATTQKQ.
OrthoDBiEOG75TMFQ.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5G861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIAILAAI LLVALQAQAE SLQERADEAT TQKQSGEDNQ DLAISFAGNG
60 70 80 90
LSALRTSGSQ ARATCYCRIG HCTILESLSG VCEISGRLYR LCCR
Length:94
Mass (Da):10,063
Last modified:March 1, 2005 - v1
Checksum:iB81361D1C9CEA17A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY746439 mRNA. Translation: AAW78342.1.
RefSeqiNP_001012657.1. NM_001012639.1.
UniGeneiPtr.6231.

Genome annotation databases

EnsembliENSPTRT00000036994; ENSPTRP00000034189; ENSPTRG00000019956.
GeneIDi463972.
KEGGiptr:463972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY746439 mRNA. Translation: AAW78342.1.
RefSeqiNP_001012657.1. NM_001012639.1.
UniGeneiPtr.6231.

3D structure databases

ProteinModelPortaliQ5G861.
SMRiQ5G861. Positions 63-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000034189.

Proteomic databases

PaxDbiQ5G861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000036994; ENSPTRP00000034189; ENSPTRG00000019956.
GeneIDi463972.
KEGGiptr:463972.

Organism-specific databases

CTDi1670.

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ5G861.
KOiK05230.
OMAiEATTQKQ.
OrthoDBiEOG75TMFQ.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes."
    Patil A., Hughes A.L., Zhang G.
    Physiol. Genomics 20:1-11(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDEF5_PANTR
AccessioniPrimary (citable) accession number: Q5G861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.