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Protein

Defensin-5

Gene

DEFA5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Defensin-5
Alternative name(s):
Defensin, alpha 5
HD5(20-94)
Cleaved into the following 4 chains:
Gene namesi
Name:DEFA5
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
PeptideiPRO_000000678920 – 94Defensin-5Add BLAST75
PeptideiPRO_000041739123 – 94HD5(23-94)By similarityAdd BLAST72
PeptideiPRO_000041739229 – 94HD5(29-94)By similarityAdd BLAST66
PeptideiPRO_000041739356 – 94HD5(56-94)By similarityAdd BLAST39
PeptideiPRO_000041739463 – 94HD5(63-94)By similarityAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5G861
PRIDEiQ5G861

Expressioni

Gene expression databases

BgeeiENSPTRG00000019956

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000034189

Structurei

3D structure databases

ProteinModelPortaliQ5G861
SMRiQ5G861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ5G861
KOiK05230
OMAiEATTQKQ
OrthoDBiEOG091G12GE
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5G861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTIAILAAI LLVALQAQAE SLQERADEAT TQKQSGEDNQ DLAISFAGNG
60 70 80 90
LSALRTSGSQ ARATCYCRIG HCTILESLSG VCEISGRLYR LCCR
Length:94
Mass (Da):10,063
Last modified:March 1, 2005 - v1
Checksum:iB81361D1C9CEA17A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY746439 mRNA Translation: AAW78342.1
RefSeqiNP_001012657.1, NM_001012639.1
UniGeneiPtr.6231

Genome annotation databases

EnsembliENSPTRT00000103608; ENSPTRP00000072107; ENSPTRG00000049316
GeneIDi463972
KEGGiptr:463972

Similar proteinsi

Entry informationi

Entry nameiDEF5_PANTR
AccessioniPrimary (citable) accession number: Q5G861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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