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Protein
Submitted name:

Transient receptor potential cation channel subfamily M member 2

Gene

Trpm2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • calcium ion import across plasma membrane Source: RGD
  • estrous cycle Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of oxidative stress-induced neuron death Source: RGD
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel subfamily M member 2Imported
Gene namesi
Name:Trpm2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1311889. Trpm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei751 – 77222HelicalSequence analysisAdd
BLAST
Transmembranei793 – 81624HelicalSequence analysisAdd
BLAST
Transmembranei867 – 88721HelicalSequence analysisAdd
BLAST
Transmembranei932 – 95322HelicalSequence analysisAdd
BLAST
Transmembranei1021 – 104323HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5G856.

PTM databases

iPTMnetiQ5G856.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001631.

Structurei

3D structure databases

ProteinModelPortaliQ5G856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1352 – 1503152Nudix hydrolaseInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
KOG4195. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000236350.
HOVERGENiHBG055825.
KOiK04977.
PhylomeDBiQ5G856.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR005821. Ion_trans_dom.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR029594. TRPM2.
[Graphical view]
PANTHERiPTHR13800:SF2. PTHR13800:SF2. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5G856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLDQRRTD SDQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRLLCSF
60 70 80 90 100
SSEKQENLSS WIPENIKKKE CVYFVESSKL SDAGKVVCEC GYTHEQHIEV
110 120 130 140 150
AIKPHTFQGK EWDPKKHVHE MPTDAFGDIV FTGLSQKVGK YVRLSQDTSS
160 170 180 190 200
IVIYQLMTQH WGLDVPSLLI SVTGGAKNFN MKLRLKSIFR RGLVKVAQTT
210 220 230 240 250
GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGDVITIGI ATWGTIHNRE
260 270 280 290 300
ALIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL
310 320 330 340 350
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAITNGTPCV
360 370 380 390 400
IVEGSGRVAD VIAQVAALPV SEITISLIQQ KLSVFFQEMF ETFTENQIVE
410 420 430 440 450
WTKKIQDIVR RRQLLTVFRE GKDGQQDVDV AILQALLKAS RSQDHFGHEN
460 470 480 490 500
WDHQLKLAVA WNRVDIARSE IFTDEWQWKP SDLHPMMTAA LISNKPEFVR
510 520 530 540 550
LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA EEHERLAYAS
560 570 580 590 600
ETPRLQMHHV AQVLRELLGD STQLLYPRPR YTDRPRLSLP MPHIKLNVQG
610 620 630 640 650
VSLRSLYKRS TGHVTFTIDP VRDLLIWAII QNHRELAGII WAQSQDCTAA
660 670 680 690 700
ALACSKILKE LSKEEEDTDS SEEMLALADE FEHRAIGVFT ECYRKDEERA
710 720 730 740 750
QKLLVRVSEA WGKTTCLQLA LEAKDMKFVS HGGIQAFLTK VWWGQLCVDN
760 770 780 790 800
GLWRIILCML AFPLLFTGFI SFREKRLQAL CRPARVRAFF NAPVVIFYLN
810 820 830 840 850
ILSYFAFLCL FAYVLMVDFQ PSPSWCEYLI YLWLFSLVCE ETRQLFYDPD
860 870 880 890 900
GCGLMKMASL YFSDFWNKLD VGAILLFIAG LTCRLIPATL YPGRIILSLD
910 920 930 940 950
FIMFCLRLMH IFTISKTLGP KIIIVKRMMK DVFFFLFLLA VWVVSFGVAK
960 970 980 990 1000
QAILIHNESR VDWIFRGVIY HSYLTIFGQI PTYIDGVNFS MDQCSPNGTD
1010 1020 1030 1040 1050
PYKPKCPESD WTGQAPAFPE WLTVTLLCLY LLFANILLLN LLIAMFNYTF
1060 1070 1080 1090 1100
QEVQEHTDQI WKFQRHDLIE EYHGRPPAPP PLILLSHLQL LIKRIVLKIP
1110 1120 1130 1140 1150
AKRHKQLKNK LEKNEEAALL SWELYLKENY LQNQQYQHKQ RPEQKIQDIS
1160 1170 1180 1190 1200
EKVDTMVDLL DMDRVKRSGS TEQRLASLEE QVTQMGRSLH WIVTTLKDSG
1210 1220 1230 1240 1250
FGSGAGALTL AAQRAFDEPD AELSIRKKGE EGGDGYHVSA RHLLYPDARI
1260 1270 1280 1290 1300
MRFPVPNEKV PWEAEFLIYD PPFYTAEKKD ATLTDPVGDT AEPLSKINYN
1310 1320 1330 1340 1350
VVDGLMDRCS FHGTYVVQYG FPLNPMGRTG LRGRGSLSWF GPNHTLQPVV
1360 1370 1380 1390 1400
TRWKRNQGGG ICRKSVRKML EVLVMKLPQS EHWALPGGSR EPGKMLPRKL
1410 1420 1430 1440 1450
KQVLQQEYWV TFETLLRQGT EVYKGYVDDP RNTDNAWIET VAVSIHFQDQ
1460 1470 1480 1490 1500
NDVELKRLEE NLQTHDPKES ARGLEMSTEW QVVDRRIPLY VNHKKILQKV

ASLFGAHF
Length:1,508
Mass (Da):172,346
Last modified:March 1, 2005 - v1
Checksum:i9E4A05D17086EAFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY749166 mRNA. Translation: AAW65801.1.
RefSeqiNP_001011559.1. NM_001011559.1.
UniGeneiRn.214495.

Genome annotation databases

GeneIDi294329.
KEGGirno:294329.
UCSCiRGD:1311889. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY749166 mRNA. Translation: AAW65801.1.
RefSeqiNP_001011559.1. NM_001011559.1.
UniGeneiRn.214495.

3D structure databases

ProteinModelPortaliQ5G856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001631.

PTM databases

iPTMnetiQ5G856.

Proteomic databases

PaxDbiQ5G856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294329.
KEGGirno:294329.
UCSCiRGD:1311889. rat.

Organism-specific databases

CTDi7226.
RGDi1311889. Trpm2.

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
KOG4195. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000236350.
HOVERGENiHBG055825.
KOiK04977.
PhylomeDBiQ5G856.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR005821. Ion_trans_dom.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR029594. TRPM2.
[Graphical view]
PANTHERiPTHR13800:SF2. PTHR13800:SF2. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones."
    Hill K., Tigue N.J., Kelsell R.E., Benham C.D., McNulty S., Schaefer M., Randall A.D.
    Neuropharmacology 50:89-97(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5G856_RAT
AccessioniPrimary (citable) accession number: Q5G856
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.