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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:cox2Imported
Synonyms:COX2Imported
Encoded oniMitochondrionImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 46HelicalSequence analysisAdd BLAST20
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000034374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91COX2_TMInterPro annotationAdd BLAST91
Domaini92 – 225COX2_CUAInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000017410.
HOVERGENiHBG012727.
OMAiWSYEYTD.
OrthoDBiEOG091G0IO9.

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR036257. Cyt_c_oxidase_su2_TM_sf.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5G7I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPSQLGFQ DAASPIMEEL LHFHDHTLMA VFLISTLVLY IITIMMTTKL
60 70 80 90 100
TNTNSMDAQE IEMVWTIMPA IILIMIALPS LRILYLMDEV NDPHLTVKTI
110 120 130 140 150
GHQWYWSYEY TNYEDLSFDS YMIPTSDLTP GQFRLLEVDN RMVVPMESPI
160 170 180 190 200
RLLVTAEDVL HSWALPSFGV KTDAIPGRLN QTSFIATRPG VFYGQCSEIC
210 220
GANHSFMPIV VEAVPLNDFE NWSSSMLEA
Length:229
Mass (Da):25,995
Last modified:March 1, 2005 - v1
Checksum:i3BD99F25824D0859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY789013 Genomic DNA. Translation: AAV49101.1.
RefSeqiYP_203373.1. NC_006839.1.

Genome annotation databases

EnsembliENSXETT00000066499; ENSXETP00000064135; ENSXETG00000034374.
GeneIDi3283495.

Similar proteinsi

Entry informationi

Entry nameiQ5G7I7_XENTR
AccessioniPrimary (citable) accession number: Q5G7I7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported