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Protein

Arylsulfatase J

Gene

ARSJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84CalciumBy similarity1
Metal bindingi85CalciumBy similarity1
Metal bindingi122Calcium; via 3-oxoalanineBy similarity1
Binding sitei176SubstrateBy similarity1
Active sitei178By similarity1
Binding sitei269SubstrateBy similarity1
Metal bindingi327CalciumBy similarity1
Metal bindingi328CalciumBy similarity1
Binding sitei345SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS17567-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase J (EC:3.1.6.-)
Short name:
ASJ
Gene namesi
Name:ARSJ
ORF Names:UNQ372/PRO708
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26286. ARSJ.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79642.
OpenTargetsiENSG00000180801.
PharmGKBiPA143485310.

Polymorphism and mutation databases

BioMutaiARSJ.
DMDMi74722580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 49Sequence analysisAdd BLAST49
ChainiPRO_000004221750 – 599Arylsulfatase JAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1223-oxoalanine (Cys)By similarity1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi527N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FYB0.
PRIDEiQ5FYB0.

PTM databases

iPTMnetiQ5FYB0.
PhosphoSitePlusiQ5FYB0.

Expressioni

Gene expression databases

BgeeiENSG00000180801.
CleanExiHS_ARSJ.
ExpressionAtlasiQ5FYB0. baseline and differential.
GenevisibleiQ5FYB0. HS.

Organism-specific databases

HPAiHPA036481.
HPA036482.

Interactioni

Protein-protein interaction databases

BioGridi122770. 4 interactors.
IntActiQ5FYB0. 1 interactor.
STRINGi9606.ENSP00000320219.

Structurei

3D structure databases

ProteinModelPortaliQ5FYB0.
SMRiQ5FYB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135354.
HOVERGENiHBG004282.
InParanoidiQ5FYB0.
KOiK12375.
OMAiAIRVQHW.
OrthoDBiEOG091G06C3.
PhylomeDBiQ5FYB0.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FYB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRGCAGHP PPPSPQACVC PGKMLAMGAL AGFWILCLLT YGYLSWGQAL
60 70 80 90 100
EEEEEGALLA QAGEKLEPST TSTSQPHLIF ILADDQGFRD VGYHGSEIKT
110 120 130 140 150
PTLDKLAAEG VKLENYYVQP ICTPSRSQFI TGKYQIHTGL QHSIIRPTQP
160 170 180 190 200
NCLPLDNATL PQKLKEVGYS THMVGKWHLG FYRKECMPTR RGFDTFFGSL
210 220 230 240 250
LGSGDYYTHY KCDSPGMCGY DLYENDNAAW DYDNGIYSTQ MYTQRVQQIL
260 270 280 290 300
ASHNPTKPIF LYIAYQAVHS PLQAPGRYFE HYRSIININR RRYAAMLSCL
310 320 330 340 350
DEAINNVTLA LKTYGFYNNS IIIYSSDNGG QPTAGGSNWP LRGSKGTYWE
360 370 380 390 400
GGIRAVGFVH SPLLKNKGTV CKELVHITDW YPTLISLAEG QIDEDIQLDG
410 420 430 440 450
YDIWETISEG LRSPRVDILH NIDPIYTKAK NGSWAAGYGI WNTAIQSAIR
460 470 480 490 500
VQHWKLLTGN PGYSDWVPPQ SFSNLGPNRW HNERITLSTG KSVWLFNITA
510 520 530 540 550
DPYERVDLSN RYPGIVKKLL RRLSQFNKTA VPVRYPPKDP RSNPRLNGGV
560 570 580 590
WGPWYKEETK KKKPSKNQAE KKQKKSKKKK KKQQKAVSGS TCHSGVTCG
Length:599
Mass (Da):67,235
Last modified:March 1, 2005 - v1
Checksum:i1548898E95C43A7A
GO

Sequence cautioni

The sequence AAQ89010 differs from that shown. Reason: Frameshift at position 425.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182Y → N in AAQ89010 (PubMed:12975309).Curated1
Sequence conflicti263I → T in AAQ89010 (PubMed:12975309).Curated1
Sequence conflicti495L → P in AAH89445 (PubMed:15489334).Curated1
Sequence conflicti576S → K in AAH89445 (PubMed:15489334).Curated1
Sequence conflicti590 – 599STCHSGVTCG → KPANLAR in CAJ18095 (PubMed:16500042).Curated10
Sequence conflicti590 – 599STCHSGVTCG → KPANLAR in AAQ89010 (PubMed:12975309).Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052515565S → R.Corresponds to variant rs17046588dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875938 mRNA. Translation: AAW66666.1.
AM049401 mRNA. Translation: CAJ18095.1.
AY358647 mRNA. Translation: AAQ89010.1. Frameshift.
AC104779 Genomic DNA. No translation available.
BC089445 mRNA. Translation: AAH89445.1.
BC132879 mRNA. Translation: AAI32880.1.
BC132881 mRNA. Translation: AAI32882.1.
BC144265 mRNA. Translation: AAI44266.1.
CCDSiCCDS43264.1.
RefSeqiNP_078866.3. NM_024590.3.
XP_005263269.1. XM_005263212.4.
XP_016864081.1. XM_017008592.1.
UniGeneiHs.22895.
Hs.700496.
Hs.712042.

Genome annotation databases

EnsembliENST00000315366; ENSP00000320219; ENSG00000180801.
GeneIDi79642.
KEGGihsa:79642.
UCSCiuc003ibq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875938 mRNA. Translation: AAW66666.1.
AM049401 mRNA. Translation: CAJ18095.1.
AY358647 mRNA. Translation: AAQ89010.1. Frameshift.
AC104779 Genomic DNA. No translation available.
BC089445 mRNA. Translation: AAH89445.1.
BC132879 mRNA. Translation: AAI32880.1.
BC132881 mRNA. Translation: AAI32882.1.
BC144265 mRNA. Translation: AAI44266.1.
CCDSiCCDS43264.1.
RefSeqiNP_078866.3. NM_024590.3.
XP_005263269.1. XM_005263212.4.
XP_016864081.1. XM_017008592.1.
UniGeneiHs.22895.
Hs.700496.
Hs.712042.

3D structure databases

ProteinModelPortaliQ5FYB0.
SMRiQ5FYB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122770. 4 interactors.
IntActiQ5FYB0. 1 interactor.
STRINGi9606.ENSP00000320219.

PTM databases

iPTMnetiQ5FYB0.
PhosphoSitePlusiQ5FYB0.

Polymorphism and mutation databases

BioMutaiARSJ.
DMDMi74722580.

Proteomic databases

PaxDbiQ5FYB0.
PRIDEiQ5FYB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315366; ENSP00000320219; ENSG00000180801.
GeneIDi79642.
KEGGihsa:79642.
UCSCiuc003ibq.2. human.

Organism-specific databases

CTDi79642.
DisGeNETi79642.
GeneCardsiARSJ.
HGNCiHGNC:26286. ARSJ.
HPAiHPA036481.
HPA036482.
MIMi610010. gene.
neXtProtiNX_Q5FYB0.
OpenTargetsiENSG00000180801.
PharmGKBiPA143485310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135354.
HOVERGENiHBG004282.
InParanoidiQ5FYB0.
KOiK12375.
OMAiAIRVQHW.
OrthoDBiEOG091G06C3.
PhylomeDBiQ5FYB0.
TreeFamiTF314186.

Enzyme and pathway databases

BioCyciZFISH:HS17567-MONOMER.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Miscellaneous databases

ChiTaRSiARSJ. human.
GenomeRNAii79642.
PROiQ5FYB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180801.
CleanExiHS_ARSJ.
ExpressionAtlasiQ5FYB0. baseline and differential.
GenevisibleiQ5FYB0. HS.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSJ_HUMAN
AccessioniPrimary (citable) accession number: Q5FYB0
Secondary accession number(s): A2RUG0
, B7ZM45, Q1HA39, Q5FWE4, Q6UWT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.