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Q5FYA8 (ARSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arylsulfatase H

Short name=ASH
EC=3.1.6.-
Gene names
Name:ARSH
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity By similarity.

Sequence similarities

Belongs to the sulfatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Arylsulfatase H
PRO_0000295623

Regions

Transmembrane167 – 18721Helical; Potential
Transmembrane189 – 20921Helical; Potential

Sites

Active site1171 By similarity
Metal binding151Calcium By similarity
Metal binding161Calcium By similarity
Metal binding551Calcium; via 3-oxoalanine By similarity
Metal binding3231Calcium By similarity
Metal binding3241Calcium By similarity
Binding site1151Substrate By similarity
Binding site2711Substrate By similarity
Binding site3481Substrate By similarity

Amino acid modifications

Modified residue5513-oxoalanine (Cys) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FYA8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: E7428B679C76E78F

FASTA56263,525
        10         20         30         40         50         60 
MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA AASMCTPSRA 

        70         80         90        100        110        120 
AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA KLLQHRGYRT GLIGKWHLGL 

       130        140        150        160        170        180 
SCASRNDHCY HPLNHGFHYF YGVPFGLLSD CQASKTPELH RWLRIKLWIS TVALALVPFL 

       190        200        210        220        230        240 
LLIPKFARWF SVPWKVIFVF ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK 

       250        260        270        280        290        300 
VASLMLKEAL AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV 

       310        320        330        340        350        360 
GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM GGWEGGIRVP 

       370        380        390        400        410        420 
GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR VIDGQNLMPL LEGRASHSDH 

       430        440        450        460        470        480 
EFLFHYCGVY LHTVRWHQKD CATVWKAHYV TPKFYPEGTG ACYGSGICSC SGDVTYHDPP 

       490        500        510        520        530        540 
LLFDISRDPS EALPLNPDNE PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ 

       550        560 
PCCGTFPFCG CDKEDDILPM AP 

« Hide

References

[1]"Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
Sardiello M., Annunziata I., Roma G., Ballabio A.
Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY875940 mRNA. Translation: AAW66668.1.
RefSeqNP_001011719.1. NM_001011719.1.
UniGeneHs.351533.

3D structure databases

ProteinModelPortalQ5FYA8.
SMRQ5FYA8. Positions 5-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000370522.

Polymorphism databases

DMDM74722579.

Proteomic databases

PaxDbQ5FYA8.
PRIDEQ5FYA8.

Protocols and materials databases

DNASU347527.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000381130; ENSP00000370522; ENSG00000205667.
GeneID347527.
KEGGhsa:347527.
UCSCuc011mhj.2. human.

Organism-specific databases

CTD347527.
GeneCardsGC0XP002919.
HGNCHGNC:32488. ARSH.
HPAHPA050011.
MIM300586. gene.
neXtProtNX_Q5FYA8.
PharmGKBPA143485308.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3119.
HOGENOMHOG000135352.
HOVERGENHBG004283.
InParanoidQ5FYA8.
KOK12374.
OMAATVWKVH.
OrthoDBEOG7QZG9J.
PhylomeDBQ5FYA8.
TreeFamTF314186.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_17015. Metabolism of proteins.

Gene expression databases

BgeeQ5FYA8.
CleanExHS_ARSH.
GenevestigatorQ5FYA8.

Family and domain databases

Gene3D3.40.720.10. 2 hits.
InterProIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view]
PfamPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMSSF53649. SSF53649. 1 hit.
PROSITEPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi347527.
NextBio99177.
PROQ5FYA8.
SOURCESearch...

Entry information

Entry nameARSH_HUMAN
AccessionPrimary (citable) accession number: Q5FYA8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM