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Protein

Arylsulfatase H

Gene

ARSH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15CalciumBy similarity1
Metal bindingi16CalciumBy similarity1
Metal bindingi55Calcium; via 3-oxoalanineBy similarity1
Binding sitei115SubstrateBy similarity1
Active sitei117By similarity1
Binding sitei271SubstrateBy similarity1
Metal bindingi323CalciumBy similarity1
Metal bindingi324CalciumBy similarity1
Binding sitei348SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase H (EC:3.1.6.-)
Short name:
ASH
Gene namesi
Name:ARSH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:32488. ARSH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi347527.
OpenTargetsiENSG00000205667.
PharmGKBiPA143485308.

Polymorphism and mutation databases

BioMutaiARSH.
DMDMi74722579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002956231 – 562Arylsulfatase HAdd BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei553-oxoalanine (Cys)By similarity1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Proteomic databases

EPDiQ5FYA8.
PaxDbiQ5FYA8.
PeptideAtlasiQ5FYA8.
PRIDEiQ5FYA8.

PTM databases

iPTMnetiQ5FYA8.
PhosphoSitePlusiQ5FYA8.

Expressioni

Gene expression databases

BgeeiENSG00000205667.
CleanExiHS_ARSH.

Organism-specific databases

HPAiHPA050011.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370522.

Structurei

3D structure databases

ProteinModelPortaliQ5FYA8.
SMRiQ5FYA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ5FYA8.
KOiK12374.
OMAiVPQQFSV.
OrthoDBiEOG091G07AL.
PhylomeDBiQ5FYA8.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FYA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA
60 70 80 90 100
AASMCTPSRA AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA
110 120 130 140 150
KLLQHRGYRT GLIGKWHLGL SCASRNDHCY HPLNHGFHYF YGVPFGLLSD
160 170 180 190 200
CQASKTPELH RWLRIKLWIS TVALALVPFL LLIPKFARWF SVPWKVIFVF
210 220 230 240 250
ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK VASLMLKEAL
260 270 280 290 300
AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV
310 320 330 340 350
GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM
360 370 380 390 400
GGWEGGIRVP GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR
410 420 430 440 450
VIDGQNLMPL LEGRASHSDH EFLFHYCGVY LHTVRWHQKD CATVWKAHYV
460 470 480 490 500
TPKFYPEGTG ACYGSGICSC SGDVTYHDPP LLFDISRDPS EALPLNPDNE
510 520 530 540 550
PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ PCCGTFPFCG
560
CDKEDDILPM AP
Length:562
Mass (Da):63,525
Last modified:March 1, 2005 - v1
Checksum:iE7428B679C76E78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875940 mRNA. Translation: AAW66668.1.
CCDSiCCDS35198.1.
RefSeqiNP_001011719.1. NM_001011719.1.
UniGeneiHs.351533.

Genome annotation databases

EnsembliENST00000381130; ENSP00000370522; ENSG00000205667.
GeneIDi347527.
KEGGihsa:347527.
UCSCiuc011mhj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY875940 mRNA. Translation: AAW66668.1.
CCDSiCCDS35198.1.
RefSeqiNP_001011719.1. NM_001011719.1.
UniGeneiHs.351533.

3D structure databases

ProteinModelPortaliQ5FYA8.
SMRiQ5FYA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000370522.

PTM databases

iPTMnetiQ5FYA8.
PhosphoSitePlusiQ5FYA8.

Polymorphism and mutation databases

BioMutaiARSH.
DMDMi74722579.

Proteomic databases

EPDiQ5FYA8.
PaxDbiQ5FYA8.
PeptideAtlasiQ5FYA8.
PRIDEiQ5FYA8.

Protocols and materials databases

DNASUi347527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381130; ENSP00000370522; ENSG00000205667.
GeneIDi347527.
KEGGihsa:347527.
UCSCiuc011mhj.3. human.

Organism-specific databases

CTDi347527.
DisGeNETi347527.
GeneCardsiARSH.
HGNCiHGNC:32488. ARSH.
HPAiHPA050011.
MIMi300586. gene.
neXtProtiNX_Q5FYA8.
OpenTargetsiENSG00000205667.
PharmGKBiPA143485308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ5FYA8.
KOiK12374.
OMAiVPQQFSV.
OrthoDBiEOG091G07AL.
PhylomeDBiQ5FYA8.
TreeFamiTF314186.

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Miscellaneous databases

GenomeRNAii347527.
PROiQ5FYA8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205667.
CleanExiHS_ARSH.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSH_HUMAN
AccessioniPrimary (citable) accession number: Q5FYA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.