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Q5FYA8

- ARSH_HUMAN

UniProt

Q5FYA8 - ARSH_HUMAN

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Protein

Arylsulfatase H

Gene

ARSH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151CalciumBy similarity
Metal bindingi16 – 161CalciumBy similarity
Metal bindingi55 – 551Calcium; via 3-oxoalanineBy similarity
Binding sitei115 – 1151SubstrateBy similarity
Active sitei117 – 1171By similarity
Binding sitei271 – 2711SubstrateBy similarity
Metal bindingi323 – 3231CalciumBy similarity
Metal bindingi324 – 3241CalciumBy similarity
Binding sitei348 – 3481SubstrateBy similarity

GO - Molecular functioni

  1. arylsulfatase activity Source: HGNC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. glycosphingolipid metabolic process Source: Reactome
  3. post-translational protein modification Source: Reactome
  4. small molecule metabolic process Source: Reactome
  5. sphingolipid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_116105. Glycosphingolipid metabolism.
REACT_121036. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase H (EC:3.1.6.-)
Short name:
ASH
Gene namesi
Name:ARSH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:32488. ARSH.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Arylsulfatase HPRO_0000295623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 5513-oxoalanine (Cys)By similarity

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Proteomic databases

PaxDbiQ5FYA8.
PRIDEiQ5FYA8.

Expressioni

Gene expression databases

BgeeiQ5FYA8.
CleanExiHS_ARSH.
GenevestigatoriQ5FYA8.

Organism-specific databases

HPAiHPA050011.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000370522.

Structurei

3D structure databases

ProteinModelPortaliQ5FYA8.
SMRiQ5FYA8. Positions 5-554.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3119.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiQ5FYA8.
KOiK12374.
OMAiATVWKVH.
OrthoDBiEOG7QZG9J.
PhylomeDBiQ5FYA8.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FYA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA
60 70 80 90 100
AASMCTPSRA AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA
110 120 130 140 150
KLLQHRGYRT GLIGKWHLGL SCASRNDHCY HPLNHGFHYF YGVPFGLLSD
160 170 180 190 200
CQASKTPELH RWLRIKLWIS TVALALVPFL LLIPKFARWF SVPWKVIFVF
210 220 230 240 250
ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK VASLMLKEAL
260 270 280 290 300
AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV
310 320 330 340 350
GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM
360 370 380 390 400
GGWEGGIRVP GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR
410 420 430 440 450
VIDGQNLMPL LEGRASHSDH EFLFHYCGVY LHTVRWHQKD CATVWKAHYV
460 470 480 490 500
TPKFYPEGTG ACYGSGICSC SGDVTYHDPP LLFDISRDPS EALPLNPDNE
510 520 530 540 550
PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ PCCGTFPFCG
560
CDKEDDILPM AP
Length:562
Mass (Da):63,525
Last modified:March 1, 2005 - v1
Checksum:iE7428B679C76E78F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875940 mRNA. Translation: AAW66668.1.
CCDSiCCDS35198.1.
RefSeqiNP_001011719.1. NM_001011719.1.
UniGeneiHs.351533.

Genome annotation databases

EnsembliENST00000381130; ENSP00000370522; ENSG00000205667.
GeneIDi347527.
KEGGihsa:347527.
UCSCiuc011mhj.2. human.

Polymorphism databases

DMDMi74722579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY875940 mRNA. Translation: AAW66668.1 .
CCDSi CCDS35198.1.
RefSeqi NP_001011719.1. NM_001011719.1.
UniGenei Hs.351533.

3D structure databases

ProteinModelPortali Q5FYA8.
SMRi Q5FYA8. Positions 5-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000370522.

Polymorphism databases

DMDMi 74722579.

Proteomic databases

PaxDbi Q5FYA8.
PRIDEi Q5FYA8.

Protocols and materials databases

DNASUi 347527.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381130 ; ENSP00000370522 ; ENSG00000205667 .
GeneIDi 347527.
KEGGi hsa:347527.
UCSCi uc011mhj.2. human.

Organism-specific databases

CTDi 347527.
GeneCardsi GC0XP002919.
HGNCi HGNC:32488. ARSH.
HPAi HPA050011.
MIMi 300586. gene.
neXtProti NX_Q5FYA8.
PharmGKBi PA143485308.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3119.
GeneTreei ENSGT00760000119062.
HOGENOMi HOG000135352.
HOVERGENi HBG004283.
InParanoidi Q5FYA8.
KOi K12374.
OMAi ATVWKVH.
OrthoDBi EOG7QZG9J.
PhylomeDBi Q5FYA8.
TreeFami TF314186.

Enzyme and pathway databases

Reactomei REACT_116105. Glycosphingolipid metabolism.
REACT_121036. The activation of arylsulfatases.

Miscellaneous databases

GenomeRNAii 347527.
NextBioi 99177.
PROi Q5FYA8.
SOURCEi Search...

Gene expression databases

Bgeei Q5FYA8.
CleanExi HS_ARSH.
Genevestigatori Q5FYA8.

Family and domain databases

Gene3Di 3.40.720.10. 2 hits.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR000917. Sulfatase.
IPR024607. Sulfatase_CS.
[Graphical view ]
Pfami PF00884. Sulfatase. 1 hit.
[Graphical view ]
SUPFAMi SSF53649. SSF53649. 1 hit.
PROSITEi PS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
    Sardiello M., Annunziata I., Roma G., Ballabio A.
    Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiARSH_HUMAN
AccessioniPrimary (citable) accession number: Q5FYA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3