Q5FYA8 (ARSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylsulfatase H
Short name=ASH
EC=3.1.6.-

Gene names

Name:

ARSH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Binds 1 calcium ion per subunit By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Post-translational modification	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity By similarity.
Sequence similarities	Belongs to the sulfatase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycosphingolipid metabolic process Traceable author statement. Source: Reactome phospholipid metabolic process Traceable author statement. Source: Reactome post-translational protein modification Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum lumen Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	arylsulfatase activity Traceable author statement Ref.1. Source: HGNC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 562	562	Arylsulfatase H		PRO_0000295623
Regions
	Transmembrane	167 – 187	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
Sites
	Active site	117	1	By similarity
	Metal binding	15	1	Calcium By similarity
	Metal binding	16	1	Calcium By similarity
	Metal binding	55	1	Calcium; via 3-oxoalanine By similarity
	Metal binding	323	1	Calcium By similarity
	Metal binding	324	1	Calcium By similarity
	Binding site	115	1	Substrate By similarity
	Binding site	271	1	Substrate By similarity
	Binding site	348	1	Substrate By similarity
Amino acid modifications
	Modified residue	55	1	3-oxoalanine (Cys) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FYA8 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: E7428B679C76E78F	FASTA	562	63,525
	10 20 30 40 50 60 MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA AASMCTPSRA 70 80 90 100 110 120 AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA KLLQHRGYRT GLIGKWHLGL 130 140 150 160 170 180 SCASRNDHCY HPLNHGFHYF YGVPFGLLSD CQASKTPELH RWLRIKLWIS TVALALVPFL 190 200 210 220 230 240 LLIPKFARWF SVPWKVIFVF ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK 250 260 270 280 290 300 VASLMLKEAL AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV 310 320 330 340 350 360 GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM GGWEGGIRVP 370 380 390 400 410 420 GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR VIDGQNLMPL LEGRASHSDH 430 440 450 460 470 480 EFLFHYCGVY LHTVRWHQKD CATVWKAHYV TPKFYPEGTG ACYGSGICSC SGDVTYHDPP 490 500 510 520 530 540 LLFDISRDPS EALPLNPDNE PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ 550 560 PCCGTFPFCG CDKEDDILPM AP

References

[1]	"Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship." Sardiello M., Annunziata I., Roma G., Ballabio A. Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY875940 mRNA. Translation: AAW66668.1.
IPI	IPI00233062.
RefSeq	NP_001011719.1. NM_001011719.1.
UniGene	Hs.351533.
3D structure databases
HSSP	HSSP built from PDB template 1P49 based on UniProtKB P08842.
ProteinModelPortal	Q5FYA8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000370522.
Polymorphism databases
DMDM	74722579.
Proteomic databases
PaxDb	Q5FYA8.
PRIDE	Q5FYA8.
Protocols and materials databases
DNASU	347527.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000381130; ENSP00000370522; ENSG00000205667.
GeneID	347527.
KEGG	hsa:347527.
UCSC	uc011mhj.2. human.
Organism-specific databases
CTD	347527.
GeneCards	GC0XP002919.
HGNC	HGNC:32488. ARSH.
HPA	HPA050011.
MIM	300586. gene.
neXtProt	NX_Q5FYA8.
PharmGKB	PA143485308.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG3119.
HOGENOM	HOG000135352.
HOVERGEN	HBG004283.
InParanoid	Q5FYA8.
KO	K12374.
OMA	ATVWKVH.
OrthoDB	EOG4V4379.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_17015. Metabolism of proteins.
Gene expression databases
Bgee	Q5FYA8.
CleanEx	HS_ARSH.
Genevestigator	Q5FYA8.
Family and domain databases
Gene3D	3.40.720.10. 2 hits.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR000917. Sulfatase. IPR024607. Sulfatase_CS. [Graphical view]
Pfam	PF00884. Sulfatase. 1 hit. [Graphical view]
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
PROSITE	PS00523. SULFATASE_1. 1 hit. PS00149. SULFATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	347527.
NextBio	99177.
SOURCE	Search...

Entry information

Entry name

ARSH_HUMAN

Accession

Primary (citable) accession number: Q5FYA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.