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Q5FYA8

- ARSH_HUMAN

UniProt

Q5FYA8 - ARSH_HUMAN

Protein

Arylsulfatase H

Gene

ARSH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151CalciumBy similarity
    Metal bindingi16 – 161CalciumBy similarity
    Metal bindingi55 – 551Calcium; via 3-oxoalanineBy similarity
    Binding sitei115 – 1151SubstrateBy similarity
    Active sitei117 – 1171By similarity
    Binding sitei271 – 2711SubstrateBy similarity
    Metal bindingi323 – 3231CalciumBy similarity
    Metal bindingi324 – 3241CalciumBy similarity
    Binding sitei348 – 3481SubstrateBy similarity

    GO - Molecular functioni

    1. arylsulfatase activity Source: HGNC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. glycosphingolipid metabolic process Source: Reactome
    3. post-translational protein modification Source: Reactome
    4. small molecule metabolic process Source: Reactome
    5. sphingolipid metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_116105. Glycosphingolipid metabolism.
    REACT_121036. The activation of arylsulfatases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylsulfatase H (EC:3.1.6.-)
    Short name:
    ASH
    Gene namesi
    Name:ARSH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:32488. ARSH.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485308.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Arylsulfatase HPRO_0000295623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 5513-oxoalanine (Cys)By similarity

    Post-translational modificationi

    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

    Proteomic databases

    PaxDbiQ5FYA8.
    PRIDEiQ5FYA8.

    Expressioni

    Gene expression databases

    BgeeiQ5FYA8.
    CleanExiHS_ARSH.
    GenevestigatoriQ5FYA8.

    Organism-specific databases

    HPAiHPA050011.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000370522.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FYA8.
    SMRiQ5FYA8. Positions 5-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sulfatase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3119.
    HOGENOMiHOG000135352.
    HOVERGENiHBG004283.
    InParanoidiQ5FYA8.
    KOiK12374.
    OMAiATVWKVH.
    OrthoDBiEOG7QZG9J.
    PhylomeDBiQ5FYA8.
    TreeFamiTF314186.

    Family and domain databases

    Gene3Di3.40.720.10. 2 hits.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view]
    PfamiPF00884. Sulfatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53649. SSF53649. 1 hit.
    PROSITEiPS00523. SULFATASE_1. 1 hit.
    PS00149. SULFATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FYA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRNARPNIV LLMADDLGVG DLCCYGNNSV STPNIDRLAS EGVRLTQHLA    50
    AASMCTPSRA AFLTGRYPIR SGMVSAYNLN RAFTWLGGSG GLPTNETTFA 100
    KLLQHRGYRT GLIGKWHLGL SCASRNDHCY HPLNHGFHYF YGVPFGLLSD 150
    CQASKTPELH RWLRIKLWIS TVALALVPFL LLIPKFARWF SVPWKVIFVF 200
    ALLAFLFFTS WYSSYGFTRR WNCILMRNHE IIQQPMKEEK VASLMLKEAL 250
    AFIERYKREP FLLFFSFLHV HTPLISKKKF VGRSKYGRYG DNVEEMDWMV 300
    GKILDALDQE RLANHTLVYF TSDNGGHLEP LDGAVQLGGW NGIYKGGKGM 350
    GGWEGGIRVP GIFRWPSVLE AGRVINEPTS LMDIYPTLSY IGGGILSQDR 400
    VIDGQNLMPL LEGRASHSDH EFLFHYCGVY LHTVRWHQKD CATVWKAHYV 450
    TPKFYPEGTG ACYGSGICSC SGDVTYHDPP LLFDISRDPS EALPLNPDNE 500
    PLFDSVIKKM EAAIREHRRT LTPVPQQFSV FNTIWKPWLQ PCCGTFPFCG 550
    CDKEDDILPM AP 562
    Length:562
    Mass (Da):63,525
    Last modified:March 1, 2005 - v1
    Checksum:iE7428B679C76E78F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875940 mRNA. Translation: AAW66668.1.
    CCDSiCCDS35198.1.
    RefSeqiNP_001011719.1. NM_001011719.1.
    UniGeneiHs.351533.

    Genome annotation databases

    EnsembliENST00000381130; ENSP00000370522; ENSG00000205667.
    GeneIDi347527.
    KEGGihsa:347527.
    UCSCiuc011mhj.2. human.

    Polymorphism databases

    DMDMi74722579.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY875940 mRNA. Translation: AAW66668.1 .
    CCDSi CCDS35198.1.
    RefSeqi NP_001011719.1. NM_001011719.1.
    UniGenei Hs.351533.

    3D structure databases

    ProteinModelPortali Q5FYA8.
    SMRi Q5FYA8. Positions 5-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000370522.

    Polymorphism databases

    DMDMi 74722579.

    Proteomic databases

    PaxDbi Q5FYA8.
    PRIDEi Q5FYA8.

    Protocols and materials databases

    DNASUi 347527.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381130 ; ENSP00000370522 ; ENSG00000205667 .
    GeneIDi 347527.
    KEGGi hsa:347527.
    UCSCi uc011mhj.2. human.

    Organism-specific databases

    CTDi 347527.
    GeneCardsi GC0XP002919.
    HGNCi HGNC:32488. ARSH.
    HPAi HPA050011.
    MIMi 300586. gene.
    neXtProti NX_Q5FYA8.
    PharmGKBi PA143485308.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3119.
    HOGENOMi HOG000135352.
    HOVERGENi HBG004283.
    InParanoidi Q5FYA8.
    KOi K12374.
    OMAi ATVWKVH.
    OrthoDBi EOG7QZG9J.
    PhylomeDBi Q5FYA8.
    TreeFami TF314186.

    Enzyme and pathway databases

    Reactomei REACT_116105. Glycosphingolipid metabolism.
    REACT_121036. The activation of arylsulfatases.

    Miscellaneous databases

    GenomeRNAii 347527.
    NextBioi 99177.
    PROi Q5FYA8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5FYA8.
    CleanExi HS_ARSH.
    Genevestigatori Q5FYA8.

    Family and domain databases

    Gene3Di 3.40.720.10. 2 hits.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR000917. Sulfatase.
    IPR024607. Sulfatase_CS.
    [Graphical view ]
    Pfami PF00884. Sulfatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53649. SSF53649. 1 hit.
    PROSITEi PS00523. SULFATASE_1. 1 hit.
    PS00149. SULFATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship."
      Sardiello M., Annunziata I., Roma G., Ballabio A.
      Hum. Mol. Genet. 14:3203-3217(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiARSH_HUMAN
    AccessioniPrimary (citable) accession number: Q5FYA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3