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Protein

AH receptor-interacting protein

Gene

Aip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
Immunophilin XAP2
Gene namesi
Name:Aip
Synonyms:Xap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628619. Aip.

Subcellular locationi

GO - Cellular componenti

  • aryl hydrocarbon receptor complex Source: Ensembl
  • cytosol Source: RGD
  • nucleoplasm Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330AH receptor-interacting proteinPRO_0000288800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FWY5.
PRIDEiQ5FWY5.

Expressioni

Gene expression databases

GenevisibleiQ5FWY5. RN.

Interactioni

Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
Pde2aQ010622EBI-1786045,EBI-1786062

GO - Molecular functioni

Protein-protein interaction databases

BioGridi251863. 2 interactions.
IntActiQ5FWY5. 1 interaction.
STRINGi10116.ENSRNOP00000000599.

Structurei

3D structure databases

ProteinModelPortaliQ5FWY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 12191PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST
Repeati179 – 21234TPR 1Add
BLAST
Repeati231 – 26434TPR 2Add
BLAST
Repeati265 – 29834TPR 3Add
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiQ5FWY5.
KOiK17767.
OMAiYEVIEHC.
OrthoDBiEOG7J9VQ0.
PhylomeDBiQ5FWY5.
TreeFamiTF314507.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLIARLRE DGIQKRVIQE GRGELPEFQD GTKATFHFRT LHSDPEGSVI
60 70 80 90 100
DDSRARGKPM ELIIGKKFKL PVWETIVRTM REGETAQFLC DVKHTVLYPL
110 120 130 140 150
VAKSLRNIAE GKDPLEGQRH CCGIAQMHEH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HIEMLKVESP GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGQVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PDWIQLDLQI TPLLLNYCQC KLVAQEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELRALE ARIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,599
Last modified:March 1, 2005 - v1
Checksum:iFE96E23EBFAA2924
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621L → F in AAN77242 (PubMed:12810716).Curated
Sequence conflicti89 – 891L → F in AAN77242 (PubMed:12810716).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543560 mRNA. Translation: AAN77242.1.
BC089110 mRNA. Translation: AAH89110.1.
RefSeqiNP_758830.2. NM_172327.2.
XP_006230761.1. XM_006230699.2.
XP_006230762.1. XM_006230700.2.
UniGeneiRn.95160.

Genome annotation databases

EnsembliENSRNOT00000000599; ENSRNOP00000000599; ENSRNOG00000022289.
ENSRNOT00000091542; ENSRNOP00000075162; ENSRNOG00000022289.
GeneIDi282827.
KEGGirno:282827.
UCSCiRGD:628619. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543560 mRNA. Translation: AAN77242.1.
BC089110 mRNA. Translation: AAH89110.1.
RefSeqiNP_758830.2. NM_172327.2.
XP_006230761.1. XM_006230699.2.
XP_006230762.1. XM_006230700.2.
UniGeneiRn.95160.

3D structure databases

ProteinModelPortaliQ5FWY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251863. 2 interactions.
IntActiQ5FWY5. 1 interaction.
STRINGi10116.ENSRNOP00000000599.

Proteomic databases

PaxDbiQ5FWY5.
PRIDEiQ5FWY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000599; ENSRNOP00000000599; ENSRNOG00000022289.
ENSRNOT00000091542; ENSRNOP00000075162; ENSRNOG00000022289.
GeneIDi282827.
KEGGirno:282827.
UCSCiRGD:628619. rat.

Organism-specific databases

CTDi9049.
RGDi628619. Aip.

Phylogenomic databases

eggNOGiKOG0545. Eukaryota.
ENOG410YGYV. LUCA.
GeneTreeiENSGT00390000001289.
HOGENOMiHOG000007366.
HOVERGENiHBG004198.
InParanoidiQ5FWY5.
KOiK17767.
OMAiYEVIEHC.
OrthoDBiEOG7J9VQ0.
PhylomeDBiQ5FWY5.
TreeFamiTF314507.

Miscellaneous databases

PROiQ5FWY5.

Gene expression databases

GenevisibleiQ5FWY5. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR031208. AIP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11242:SF3. PTHR11242:SF3. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
PS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2."
    Bolger G.B., Peden A.H., Steele M.R., MacKenzie C., McEwan D.G., Wallace D.A., Huston E., Baillie G.S., Houslay M.D.
    J. Biol. Chem. 278:33351-33363(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 68-78; 242-260 AND 291-304, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiAIP_RAT
AccessioniPrimary (citable) accession number: Q5FWY5
Secondary accession number(s): Q8CGW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2005
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.