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Protein

Transmembrane protein 120A

Gene

tmem120a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in adipogenesis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Gene namesi
Name:tmem120a
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5858565. tmem120a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 134134ExtracellularSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Topological domaini156 – 1616CytoplasmicSequence analysis
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Topological domaini183 – 1897ExtracellularSequence analysis
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Topological domaini211 – 27262CytoplasmicSequence analysisAdd
BLAST
Transmembranei273 – 29321HelicalSequence analysisAdd
BLAST
Topological domaini294 – 30411ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 33611CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Transmembrane protein 120APRO_0000309343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FWV6.

Expressioni

Gene expression databases

BgeeiQ5FWV6.
ExpressionAtlasiQ5FWV6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019687.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ5FWV6.
OMAiGQFWQLY.
OrthoDBiEOG790G18.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPALQDCV RDWGELQENY QDIQETHRLY KQKLEELAKL QTRCSGTIAR
60 70 80 90 100
QKKKLKELSV ELKKYKSSVK NVEEEEEQIS VLNNQIRIRE KTFFEMESFL
110 120 130 140 150
PKKNGLYLSL VLGNVNVTLL SKQSKFAYKD EYEKFKLYLT MILMVLSFIC
160 170 180 190 200
RFVLNSRVTD AVFNFLLVWY YCTLTIRESI LINNGSRIKG WWVLNHYIST
210 220 230 240 250
FLSGVMLTWP DGLMYQMFRN QFLSFSMYQS FVQFLQYYYQ SGCLYRLRAL
260 270 280 290 300
GERHNMDLTV EGFQSWMWRG LTFLLPFLFF GQFWQLYNAI TLFKLARHPE
310 320 330
CKEWQVIMCG LPFLVHFLGN FFTTLRVVHQ KFQKQN
Length:336
Mass (Da):40,246
Last modified:November 13, 2007 - v2
Checksum:i89541A0B4F1ABFEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089189 mRNA. Translation: AAH89189.1.
BC153698 mRNA. No translation available.
RefSeqiNP_001107682.1. NM_001114210.1.
UniGeneiStr.30375.

Genome annotation databases

EnsembliENSXETT00000019687; ENSXETP00000019687; ENSXETG00000008980.
GeneIDi548366.
KEGGixtr:548366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089189 mRNA. Translation: AAH89189.1.
BC153698 mRNA. No translation available.
RefSeqiNP_001107682.1. NM_001114210.1.
UniGeneiStr.30375.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019687.

Proteomic databases

PaxDbiQ5FWV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000019687; ENSXETP00000019687; ENSXETG00000008980.
GeneIDi548366.
KEGGixtr:548366.

Organism-specific databases

CTDi83862.
XenbaseiXB-GENE-5858565. tmem120a.

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ5FWV6.
OMAiGQFWQLY.
OrthoDBiEOG790G18.
TreeFamiTF313552.

Gene expression databases

BgeeiQ5FWV6.
ExpressionAtlasiQ5FWV6. baseline.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiT120A_XENTR
AccessioniPrimary (citable) accession number: Q5FWV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 11, 2015
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.