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Protein

Zinc finger protein 513

Gene

Znf513

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a role in retinal development and maintenance.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 513
Gene namesi
Name:Znf513
Synonyms:Zfp513
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1310456. Zfp513.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003530941 – 541Zinc finger protein 513Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei96PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FWU5.
PRIDEiQ5FWU5.

PTM databases

iPTMnetiQ5FWU5.
PhosphoSitePlusiQ5FWU5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005298.
GenevisibleiQ5FWU5. RN.

Interactioni

Subunit structurei

Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040002.

Structurei

3D structure databases

ProteinModelPortaliQ5FWU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 141Gly-richAdd BLAST87
Compositional biasi281 – 359Gly-richAdd BLAST79

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri150 – 172C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri206 – 228C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ5FWU5.
OMAiTSFLPDC.
OrthoDBiEOG091G05JD.
PhylomeDBiQ5FWU5.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRRKQSHPQ PVKCEGVKVD TEDSFDEGPG ALVLESDLLL GQDLEFEEEE
60 70 80 90 100
EEEEGDGHND QLMGFERDSE GDSQGARPGL PYGLSDDESG GGRALSAESE
110 120 130 140 150
VEEPARGPGE ARGERPGPAC QLCGGPTGEG PCCGAGGPGG GPPLPPRLLY
160 170 180 190 200
SCRLCAFVSH YSSHLKRHMQ THSGEKPFRC GRCPYASAQL VNLTRHTRTH
210 220 230 240 250
TGEKPYRCPH CPFACSSLGN LRRHQRTHTG PPTPPCPTCG FRCCAPRPTR
260 270 280 290 300
PPSPTEQEGT MPRRSEDALI LPDLSLHVPP GGTSFLPDCG QLRGEGEGLC
310 320 330 340 350
GTGSEPLPEL LFPWTCRGCG QELEEGEGSR LGTAMCGRCM RGESGGGGSG
360 370 380 390 400
GPQGPSDKGF ACSLCPFATH YPNHLARHMK THSGEKPFRC ARCPYASAHL
410 420 430 440 450
DNLKRHQRVH TGEKPYKCPL CPYACGNLAN LKRHGRIHSG DKPFRCSLCN
460 470 480 490 500
YSCNQSMNLK RHMLRHTGEK PFRCATCAYT TGHWDNYKRH QKVHGHGGAG
510 520 530 540
GPGLSAPEGW APPHSPPSVL STRGSAALGA TGSRALHTDS P
Length:541
Mass (Da):58,091
Last modified:March 1, 2005 - v1
Checksum:i4C3E23EB3F42B354
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089202 mRNA. Translation: AAH89202.1.
RefSeqiNP_001012110.1. NM_001012110.1.
UniGeneiRn.15926.

Genome annotation databases

EnsembliENSRNOT00000050102; ENSRNOP00000040002; ENSRNOG00000005298.
GeneIDi313913.
KEGGirno:313913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089202 mRNA. Translation: AAH89202.1.
RefSeqiNP_001012110.1. NM_001012110.1.
UniGeneiRn.15926.

3D structure databases

ProteinModelPortaliQ5FWU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040002.

PTM databases

iPTMnetiQ5FWU5.
PhosphoSitePlusiQ5FWU5.

Proteomic databases

PaxDbiQ5FWU5.
PRIDEiQ5FWU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050102; ENSRNOP00000040002; ENSRNOG00000005298.
GeneIDi313913.
KEGGirno:313913.

Organism-specific databases

CTDi101023.
RGDi1310456. Zfp513.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132304.
HOGENOMiHOG000081792.
HOVERGENiHBG097012.
InParanoidiQ5FWU5.
OMAiTSFLPDC.
OrthoDBiEOG091G05JD.
PhylomeDBiQ5FWU5.

Miscellaneous databases

PROiQ5FWU5.

Gene expression databases

BgeeiENSRNOG00000005298.
GenevisibleiQ5FWU5. RN.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 8 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN513_RAT
AccessioniPrimary (citable) accession number: Q5FWU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.