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Q5FWU3

- ATG9A_RAT

UniProt

Q5FWU3 - ATG9A_RAT

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Protein
Autophagy-related protein 9A
Gene
Atg9a, Apg9l1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H By similarity.

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. autophagy Source: RGD
  3. innate immune response Source: Ensembl
  4. late nucleophagy Source: RefGenome
  5. mitochondrion degradation Source: RefGenome
  6. piecemeal microautophagy of nucleus Source: RefGenome
  7. protein localization to Golgi apparatus Source: Ensembl
  8. protein localization to pre-autophagosomal structure Source: RefGenome
  9. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
Gene namesi
Name:Atg9a
Synonyms:Apg9l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi1310450. Atg9a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6665Cytoplasmic By similarity
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Topological domaini88 – 13144Lumenal By similarity
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Topological domaini153 – 289137Cytoplasmic By similarity
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST
Topological domaini311 – 37161Lumenal By similarity
Add
BLAST
Transmembranei372 – 39221Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 4008Cytoplasmic By similarity
Transmembranei401 – 42121Helical; Reviewed prediction
Add
BLAST
Topological domaini422 – 47352Lumenal By similarity
Add
BLAST
Transmembranei474 – 49421Helical; Reviewed prediction
Add
BLAST
Topological domaini495 – 839345Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. autophagic vacuole Source: RefGenome
  3. autophagic vacuole membrane Source: UniProtKB-SubCell
  4. cytoplasmic vesicle Source: UniProtKB-KW
  5. integral component of membrane Source: RefGenome
  6. late endosome Source: RGD
  7. late endosome membrane Source: UniProtKB-SubCell
  8. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 839838Autophagy-related protein 9A
PRO_0000119823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei18 – 181Phosphoserine By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Modified residuei656 – 6561Phosphoserine By similarity
Modified residuei735 – 7351Phosphoserine By similarity
Modified residuei738 – 7381Phosphoserine By similarity
Modified residuei741 – 7411Phosphoserine By similarity
Modified residuei828 – 8281Phosphoserine By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5FWU3.
PRIDEiQ5FWU3.

Expressioni

Gene expression databases

GenevestigatoriQ5FWU3.

Interactioni

Subunit structurei

Interacts with SUPT20H By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025710.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOGENOMiHOG000015255.
HOVERGENiHBG050539.
InParanoidiQ5FWU3.
KOiK17907.
OMAiEVVFFTR.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ5FWU3.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FWU3-1 [UniParc]FASTAAdd to Basket

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MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV    50
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH 100
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF 150
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK 200
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN 250
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL 300
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL 350
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED 400
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD 450
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE 500
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSGGQT EASVYQQAED 550
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA AGLAQGGLLP 600
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLSRDLQ GSRHRADVAS 650
ALRSFSPLQP GQAPQGRVPS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE 700
YASTEMSLHA LYMHQLHKQQ TQAEPERHVW HRRESDESGE SAPEEGGEGA 750
RAPQPIPRSA SYPCATPRPG APETTALHGG FQRRYGGITD PGTVPRAPSH 800
FSRLPLGGWA EDGQPASRHP EPVPEEGSED ELPPQVHKV 839
Length:839
Mass (Da):94,488
Last modified:March 1, 2005 - v1
Checksum:i18E9A65B55E03C14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089204 mRNA. Translation: AAH89204.1.
RefSeqiNP_001014240.1. NM_001014218.1.
XP_006245309.1. XM_006245247.1.
UniGeneiRn.35248.

Genome annotation databases

EnsembliENSRNOT00000025740; ENSRNOP00000025740; ENSRNOG00000018975.
GeneIDi363254.
KEGGirno:363254.
UCSCiRGD:1310450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089204 mRNA. Translation: AAH89204.1 .
RefSeqi NP_001014240.1. NM_001014218.1.
XP_006245309.1. XM_006245247.1.
UniGenei Rn.35248.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025710.

Proteomic databases

PaxDbi Q5FWU3.
PRIDEi Q5FWU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025740 ; ENSRNOP00000025740 ; ENSRNOG00000018975 .
GeneIDi 363254.
KEGGi rno:363254.
UCSCi RGD:1310450. rat.

Organism-specific databases

CTDi 79065.
RGDi 1310450. Atg9a.

Phylogenomic databases

eggNOGi NOG298729.
GeneTreei ENSGT00390000014839.
HOGENOMi HOG000015255.
HOVERGENi HBG050539.
InParanoidi Q5FWU3.
KOi K17907.
OMAi EVVFFTR.
OrthoDBi EOG72C4ZM.
PhylomeDBi Q5FWU3.
TreeFami TF313665.

Miscellaneous databases

NextBioi 683017.
PROi Q5FWU3.

Gene expression databases

Genevestigatori Q5FWU3.

Family and domain databases

InterProi IPR007241. Autophagy-rel_prot_9.
[Graphical view ]
PANTHERi PTHR13038. PTHR13038. 1 hit.
Pfami PF04109. APG9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiATG9A_RAT
AccessioniPrimary (citable) accession number: Q5FWU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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