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Q5FWU3 (ATG9A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
Gene names
Name:Atg9a
Synonyms:Apg9l1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H By similarity.

Subunit structure

Interacts with SUPT20H By similarity.

Subcellular location

Cytoplasmic vesicleautophagosome membrane; Multi-pass membrane protein By similarity. Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein By similarity. Late endosome membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ATG9 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 839838Autophagy-related protein 9A
PRO_0000119823

Regions

Topological domain2 – 6665Cytoplasmic By similarity
Transmembrane67 – 8721Helical; Potential
Topological domain88 – 13144Lumenal By similarity
Transmembrane132 – 15221Helical; Potential
Topological domain153 – 289137Cytoplasmic By similarity
Transmembrane290 – 31021Helical; Potential
Topological domain311 – 37161Lumenal By similarity
Transmembrane372 – 39221Helical; Potential
Topological domain393 – 4008Cytoplasmic By similarity
Transmembrane401 – 42121Helical; Potential
Topological domain422 – 47352Lumenal By similarity
Transmembrane474 – 49421Helical; Potential
Topological domain495 – 839345Cytoplasmic By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue181Phosphoserine By similarity
Modified residue6561Phosphoserine By similarity
Modified residue7351Phosphoserine By similarity
Modified residue7381Phosphoserine By similarity
Modified residue7411Phosphoserine By similarity
Modified residue8281Phosphoserine By similarity
Glycosylation991N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5FWU3 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 18E9A65B55E03C14

FASTA83994,488
        10         20         30         40         50         60 
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV YNLHQKNGFT 

        70         80         90        100        110        120 
CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH SLHPTEPVKV TLPDAFLPAQ 

       130        140        150        160        170        180 
VCSARIQENG SLITILVIAG VFWIHRLIKF IYNICCYWEI HSFYLHALRI PMSALPYCTW 

       190        200        210        220        230        240 
QEVQARIVQT QKEHQICIHK RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV 

       250        260        270        280        290        300 
VFFTRGLKYN FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL 

       310        320        330        340        350        360 
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL QSRLNRGYKP 

       370        380        390        400        410        420 
ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED VLAVEHVLTT VTLLGVTVTV 

       430        440        450        460        470        480 
CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL 

       490        500        510        520        530        540 
LSPIVTPLIL IFCLRPRALE IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSGGQT 

       550        560        570        580        590        600 
EASVYQQAED GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA AGLAQGGLLP 

       610        620        630        640        650        660 
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLSRDLQ GSRHRADVAS ALRSFSPLQP 

       670        680        690        700        710        720 
GQAPQGRVPS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE YASTEMSLHA LYMHQLHKQQ 

       730        740        750        760        770        780 
TQAEPERHVW HRRESDESGE SAPEEGGEGA RAPQPIPRSA SYPCATPRPG APETTALHGG 

       790        800        810        820        830 
FQRRYGGITD PGTVPRAPSH FSRLPLGGWA EDGQPASRHP EPVPEEGSED ELPPQVHKV 

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089204 mRNA. Translation: AAH89204.1.
RefSeqNP_001014240.1. NM_001014218.1.
XP_006245309.1. XM_006245247.1.
UniGeneRn.35248.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025710.

Proteomic databases

PaxDbQ5FWU3.
PRIDEQ5FWU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025740; ENSRNOP00000025740; ENSRNOG00000018975.
GeneID363254.
KEGGrno:363254.
UCSCRGD:1310450. rat.

Organism-specific databases

CTD79065.
RGD1310450. Atg9a.

Phylogenomic databases

eggNOGNOG298729.
GeneTreeENSGT00390000014839.
HOGENOMHOG000015255.
HOVERGENHBG050539.
InParanoidQ5FWU3.
KOK17907.
OMAEVVFFTR.
OrthoDBEOG72C4ZM.
PhylomeDBQ5FWU3.
TreeFamTF313665.

Gene expression databases

GenevestigatorQ5FWU3.

Family and domain databases

InterProIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERPTHR13038. PTHR13038. 1 hit.
PfamPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio683017.
PROQ5FWU3.

Entry information

Entry nameATG9A_RAT
AccessionPrimary (citable) accession number: Q5FWU3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families