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Protein

Autophagy-related protein 9A

Gene

Atg9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity).By similarity

GO - Biological processi

  1. autophagic vacuole assembly Source: GO_Central
  2. autophagy Source: RGD
  3. innate immune response Source: Ensembl
  4. late nucleophagy Source: GO_Central
  5. mitochondrion degradation Source: GO_Central
  6. piecemeal microautophagy of nucleus Source: GO_Central
  7. protein localization to Golgi apparatus Source: Ensembl
  8. protein localization to pre-autophagosomal structure Source: GO_Central
  9. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
Gene namesi
Name:Atg9a
Synonyms:Apg9l1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1310450. Atg9a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6665CytoplasmicBy similarityAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 13144LumenalBy similarityAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Topological domaini153 – 289137CytoplasmicBy similarityAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Topological domaini311 – 37161LumenalBy similarityAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Topological domaini393 – 4008CytoplasmicBy similarity
Transmembranei401 – 42121HelicalSequence AnalysisAdd
BLAST
Topological domaini422 – 47352LumenalBy similarityAdd
BLAST
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST
Topological domaini495 – 839345CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. autophagic vacuole Source: GO_Central
  2. autophagic vacuole membrane Source: UniProtKB-SubCell
  3. cytoplasmic vesicle Source: UniProtKB-KW
  4. integral component of membrane Source: GO_Central
  5. late endosome Source: RGD
  6. late endosome membrane Source: UniProtKB-SubCell
  7. pre-autophagosomal structure Source: GO_Central
  8. recycling endosome Source: Ensembl
  9. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 839838Autophagy-related protein 9APRO_0000119823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei18 – 181PhosphoserineBy similarity
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Modified residuei656 – 6561PhosphoserineBy similarity
Modified residuei735 – 7351PhosphoserineBy similarity
Modified residuei738 – 7381PhosphoserineBy similarity
Modified residuei741 – 7411PhosphoserineBy similarity
Modified residuei828 – 8281PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5FWU3.
PRIDEiQ5FWU3.

Expressioni

Gene expression databases

GenevestigatoriQ5FWU3.

Interactioni

Subunit structurei

Interacts with SUPT20H.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025710.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOGENOMiHOG000015255.
HOVERGENiHBG050539.
InParanoidiQ5FWU3.
KOiK17907.
OMAiKWILREY.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ5FWU3.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FWU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSGGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA AGLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLSRDLQ GSRHRADVAS
660 670 680 690 700
ALRSFSPLQP GQAPQGRVPS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ TQAEPERHVW HRRESDESGE SAPEEGGEGA
760 770 780 790 800
RAPQPIPRSA SYPCATPRPG APETTALHGG FQRRYGGITD PGTVPRAPSH
810 820 830
FSRLPLGGWA EDGQPASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,488
Last modified:March 1, 2005 - v1
Checksum:i18E9A65B55E03C14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089204 mRNA. Translation: AAH89204.1.
RefSeqiNP_001014240.1. NM_001014218.1.
XP_006245309.1. XM_006245247.2.
XP_008765484.1. XM_008767262.1.
XP_008765485.1. XM_008767263.1.
XP_008765486.1. XM_008767264.1.
XP_008765487.1. XM_008767265.1.
XP_008765488.1. XM_008767266.1.
UniGeneiRn.35248.

Genome annotation databases

EnsembliENSRNOT00000025740; ENSRNOP00000025740; ENSRNOG00000018975.
GeneIDi363254.
KEGGirno:363254.
UCSCiRGD:1310450. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089204 mRNA. Translation: AAH89204.1.
RefSeqiNP_001014240.1. NM_001014218.1.
XP_006245309.1. XM_006245247.2.
XP_008765484.1. XM_008767262.1.
XP_008765485.1. XM_008767263.1.
XP_008765486.1. XM_008767264.1.
XP_008765487.1. XM_008767265.1.
XP_008765488.1. XM_008767266.1.
UniGeneiRn.35248.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025710.

Proteomic databases

PaxDbiQ5FWU3.
PRIDEiQ5FWU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025740; ENSRNOP00000025740; ENSRNOG00000018975.
GeneIDi363254.
KEGGirno:363254.
UCSCiRGD:1310450. rat.

Organism-specific databases

CTDi79065.
RGDi1310450. Atg9a.

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOGENOMiHOG000015255.
HOVERGENiHBG050539.
InParanoidiQ5FWU3.
KOiK17907.
OMAiKWILREY.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ5FWU3.
TreeFamiTF313665.

Miscellaneous databases

NextBioi683017.
PROiQ5FWU3.

Gene expression databases

GenevestigatoriQ5FWU3.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiATG9A_RAT
AccessioniPrimary (citable) accession number: Q5FWU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2005
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.