Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5FWU3

- ATG9A_RAT

UniProt

Q5FWU3 - ATG9A_RAT

Protein

Autophagy-related protein 9A

Gene

Atg9a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H By similarity.By similarity

    GO - Biological processi

    1. autophagic vacuole assembly Source: RefGenome
    2. autophagy Source: RGD
    3. innate immune response Source: Ensembl
    4. late nucleophagy Source: RefGenome
    5. mitochondrion degradation Source: RefGenome
    6. piecemeal microautophagy of nucleus Source: RefGenome
    7. protein localization to Golgi apparatus Source: Ensembl
    8. protein localization to pre-autophagosomal structure Source: RefGenome
    9. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 9A
    Alternative name(s):
    APG9-like 1
    Gene namesi
    Name:Atg9a
    Synonyms:Apg9l1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi1310450. Atg9a.

    Subcellular locationi

    GO - Cellular componenti

    1. autophagic vacuole Source: RefGenome
    2. autophagic vacuole membrane Source: UniProtKB-SubCell
    3. cytoplasmic vesicle Source: UniProtKB-KW
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. integral component of membrane Source: RefGenome
    6. late endosome Source: RGD
    7. late endosome membrane Source: UniProtKB-SubCell
    8. pre-autophagosomal structure Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 839838Autophagy-related protein 9APRO_0000119823Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei18 – 181PhosphoserineBy similarity
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Modified residuei656 – 6561PhosphoserineBy similarity
    Modified residuei735 – 7351PhosphoserineBy similarity
    Modified residuei738 – 7381PhosphoserineBy similarity
    Modified residuei741 – 7411PhosphoserineBy similarity
    Modified residuei828 – 8281PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ5FWU3.
    PRIDEiQ5FWU3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5FWU3.

    Interactioni

    Subunit structurei

    Interacts with SUPT20H.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025710.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 6665CytoplasmicBy similarityAdd
    BLAST
    Topological domaini88 – 13144LumenalBy similarityAdd
    BLAST
    Topological domaini153 – 289137CytoplasmicBy similarityAdd
    BLAST
    Topological domaini311 – 37161LumenalBy similarityAdd
    BLAST
    Topological domaini393 – 4008CytoplasmicBy similarity
    Topological domaini422 – 47352LumenalBy similarityAdd
    BLAST
    Topological domaini495 – 839345CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG9 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG298729.
    GeneTreeiENSGT00390000014839.
    HOGENOMiHOG000015255.
    HOVERGENiHBG050539.
    InParanoidiQ5FWU3.
    KOiK17907.
    OMAiEVVFFTR.
    OrthoDBiEOG72C4ZM.
    PhylomeDBiQ5FWU3.
    TreeFamiTF313665.

    Family and domain databases

    InterProiIPR007241. Autophagy-rel_prot_9.
    [Graphical view]
    PANTHERiPTHR13038. PTHR13038. 1 hit.
    PfamiPF04109. APG9. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5FWU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV    50
    YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH 100
    SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF 150
    IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK 200
    RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN 250
    FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL 300
    CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL 350
    QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED 400
    VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD 450
    HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE 500
    IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSGGQT EASVYQQAED 550
    GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA AGLAQGGLLP 600
    ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLSRDLQ GSRHRADVAS 650
    ALRSFSPLQP GQAPQGRVPS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE 700
    YASTEMSLHA LYMHQLHKQQ TQAEPERHVW HRRESDESGE SAPEEGGEGA 750
    RAPQPIPRSA SYPCATPRPG APETTALHGG FQRRYGGITD PGTVPRAPSH 800
    FSRLPLGGWA EDGQPASRHP EPVPEEGSED ELPPQVHKV 839
    Length:839
    Mass (Da):94,488
    Last modified:March 1, 2005 - v1
    Checksum:i18E9A65B55E03C14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089204 mRNA. Translation: AAH89204.1.
    RefSeqiNP_001014240.1. NM_001014218.1.
    XP_006245309.1. XM_006245247.1.
    UniGeneiRn.35248.

    Genome annotation databases

    EnsembliENSRNOT00000025740; ENSRNOP00000025740; ENSRNOG00000018975.
    GeneIDi363254.
    KEGGirno:363254.
    UCSCiRGD:1310450. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089204 mRNA. Translation: AAH89204.1 .
    RefSeqi NP_001014240.1. NM_001014218.1.
    XP_006245309.1. XM_006245247.1.
    UniGenei Rn.35248.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025710.

    Proteomic databases

    PaxDbi Q5FWU3.
    PRIDEi Q5FWU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025740 ; ENSRNOP00000025740 ; ENSRNOG00000018975 .
    GeneIDi 363254.
    KEGGi rno:363254.
    UCSCi RGD:1310450. rat.

    Organism-specific databases

    CTDi 79065.
    RGDi 1310450. Atg9a.

    Phylogenomic databases

    eggNOGi NOG298729.
    GeneTreei ENSGT00390000014839.
    HOGENOMi HOG000015255.
    HOVERGENi HBG050539.
    InParanoidi Q5FWU3.
    KOi K17907.
    OMAi EVVFFTR.
    OrthoDBi EOG72C4ZM.
    PhylomeDBi Q5FWU3.
    TreeFami TF313665.

    Miscellaneous databases

    NextBioi 683017.
    PROi Q5FWU3.

    Gene expression databases

    Genevestigatori Q5FWU3.

    Family and domain databases

    InterProi IPR007241. Autophagy-rel_prot_9.
    [Graphical view ]
    PANTHERi PTHR13038. PTHR13038. 1 hit.
    Pfami PF04109. APG9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiATG9A_RAT
    AccessioniPrimary (citable) accession number: Q5FWU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3