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Protein

REST corepressor 2

Gene

Rcor2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Gene namesi
Name:Rcor2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 15

Organism-specific databases

RGDi1359467. Rcor2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • chromatin Source: RGD
  • nucleus Source: GO_Central
  • transcriptional repressor complex Source: GO_Central
  • transcription factor complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267781 – 523REST corepressor 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei479Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5FWT8.

PTM databases

iPTMnetiQ5FWT8.
PhosphoSitePlusiQ5FWT8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021183.
GenevisibleiQ5FWT8. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035978.

Structurei

3D structure databases

ProteinModelPortaliQ5FWT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129ELM2PROSITE-ProRule annotationAdd BLAST86
Domaini130 – 181SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini327 – 378SANT 2PROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 314Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi430 – 521Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the CoREST family.Curated
Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 2 SANT domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ5FWT8.
OMAiSPARYSN.
OrthoDBiEOG091G096Y.
PhylomeDBiQ5FWT8.
TreeFamiTF106450.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTAPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG AVSEGEPDTG DPKREPLPSR PLNARPGPGK KEIQVSQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPTAPVPV
410 420 430 440 450
EEARRGAPVP ATALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAASRHS
510 520
ARPGPQPPPT LVGAQLEPPA PSL
Length:523
Mass (Da):57,981
Last modified:March 1, 2005 - v1
Checksum:i89F8DA438C925D1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089209 mRNA. Translation: AAH89209.1.
RefSeqiNP_001014016.1. NM_001013994.1.
XP_001061203.1. XM_001061203.6.
XP_008758336.1. XM_008760114.2.
XP_008758337.1. XM_008760115.2.
XP_008768833.1. XM_008770611.1.
UniGeneiRn.209048.

Genome annotation databases

EnsembliENSRNOT00000035491; ENSRNOP00000035978; ENSRNOG00000021183.
ENSRNOT00000083585; ENSRNOP00000072780; ENSRNOG00000060849.
GeneIDi102552640.
305811.
498485.
KEGGirno:102552640.
rno:305811.
rno:498485.
UCSCiRGD:1359467. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089209 mRNA. Translation: AAH89209.1.
RefSeqiNP_001014016.1. NM_001013994.1.
XP_001061203.1. XM_001061203.6.
XP_008758336.1. XM_008760114.2.
XP_008758337.1. XM_008760115.2.
XP_008768833.1. XM_008770611.1.
UniGeneiRn.209048.

3D structure databases

ProteinModelPortaliQ5FWT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035978.

PTM databases

iPTMnetiQ5FWT8.
PhosphoSitePlusiQ5FWT8.

Proteomic databases

PaxDbiQ5FWT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035491; ENSRNOP00000035978; ENSRNOG00000021183.
ENSRNOT00000083585; ENSRNOP00000072780; ENSRNOG00000060849.
GeneIDi102552640.
305811.
498485.
KEGGirno:102552640.
rno:305811.
rno:498485.
UCSCiRGD:1359467. rat.

Organism-specific databases

CTDi283248.
498485.
RGDi1359467. Rcor2.

Phylogenomic databases

eggNOGiKOG1194. Eukaryota.
ENOG410XSIS. LUCA.
GeneTreeiENSGT00840000129748.
HOGENOMiHOG000065784.
HOVERGENiHBG079800.
InParanoidiQ5FWT8.
OMAiSPARYSN.
OrthoDBiEOG091G096Y.
PhylomeDBiQ5FWT8.
TreeFamiTF106450.

Miscellaneous databases

PROiQ5FWT8.

Gene expression databases

BgeeiENSRNOG00000021183.
GenevisibleiQ5FWT8. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCOR2_RAT
AccessioniPrimary (citable) accession number: Q5FWT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.