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Protein

REST corepressor 2

Gene

Rcor2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a component of a corepressor complex that represses transcription.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
REST corepressor 2
Gene namesi
Name:Rcor2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 1, Chromosome 15

Organism-specific databases

RGDi1359467 Rcor2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002267781 – 523REST corepressor 2Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei202PhosphoserineCombined sources1
Modified residuei479Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5FWT8

PTM databases

iPTMnetiQ5FWT8
PhosphoSitePlusiQ5FWT8

Expressioni

Gene expression databases

BgeeiENSRNOG00000021183
GenevisibleiQ5FWT8 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035978

Structurei

3D structure databases

ProteinModelPortaliQ5FWT8
SMRiQ5FWT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 129ELM2PROSITE-ProRule annotationAdd BLAST86
Domaini130 – 181SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini327 – 378SANT 2PROSITE-ProRule annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 314Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi430 – 521Pro-richAdd BLAST92

Sequence similaritiesi

Belongs to the CoREST family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1194 Eukaryota
ENOG410XSIS LUCA
GeneTreeiENSGT00840000129748
HOGENOMiHOG000065784
HOVERGENiHBG079800
InParanoidiQ5FWT8
OMAiKCFQRIQ
OrthoDBiEOG091G096Y
PhylomeDBiQ5FWT8
TreeFamiTF106450

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 2 hits

Sequencei

Sequence statusi: Complete.

Q5FWT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSVMEKPSA GSGILSRSRA KTAPNGGQPH SEDDSSEEEH SHDSMIRVGT
60 70 80 90 100
NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH
110 120 130 140 150
GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH
160 170 180 190 200
GKCFQRIQQM LPDKLIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE
210 220 230 240 250
DSDELEEGRG AVSEGEPDTG DPKREPLPSR PLNARPGPGK KEIQVSQYRH
260 270 280 290 300
HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS
310 320 330 340 350
MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD
360 370 380 390 400
FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPTAPVPV
410 420 430 440 450
EEARRGAPVP ATALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP
460 470 480 490 500
PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAASRHS
510 520
ARPGPQPPPT LVGAQLEPPA PSL
Length:523
Mass (Da):57,981
Last modified:March 1, 2005 - v1
Checksum:i89F8DA438C925D1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089209 mRNA Translation: AAH89209.1
RefSeqiNP_001014016.1, NM_001013994.1
XP_001061203.1, XM_001061203.6
XP_008758336.1, XM_008760114.2
XP_008758337.1, XM_008760115.2
XP_008768833.1, XM_008770611.1
UniGeneiRn.209048

Genome annotation databases

EnsembliENSRNOT00000035491; ENSRNOP00000035978; ENSRNOG00000021183
ENSRNOT00000083585; ENSRNOP00000072780; ENSRNOG00000060849
GeneIDi102552640
305811
498485
KEGGirno:102552640
rno:305811
rno:498485
UCSCiRGD:1359467 rat

Similar proteinsi

Entry informationi

Entry nameiRCOR2_RAT
AccessioniPrimary (citable) accession number: Q5FWT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health