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Q5FWT7

- UBCP1_RAT

UniProt

Q5FWT7 - UBCP1_RAT

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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

Ublcp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:Ublcp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1310386. Ublcp1.

Subcellular locationi

Nucleus By similarity
Note: Colocalizes with nuclear proteasomes.By similarity

GO - Cellular componenti

  1. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 318317Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

PTM databases

PhosphoSiteiQ5FWT7.

Expressioni

Gene expression databases

GenevestigatoriQ5FWT7.

Interactioni

Protein-protein interaction databases

BioGridi261993. 6 interactions.
STRINGi10116.ENSRNOP00000006063.

Structurei

3D structure databases

ProteinModelPortaliQ5FWT7.
SMRiQ5FWT7. Positions 3-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 294162PhosphataseBy similarityAdd
BLAST

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG310886.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ5FWT7.
KOiK17618.
OMAiELNPPRE.
OrthoDBiEOG74TX01.
PhylomeDBiQ5FWT7.
TreeFamiTF323786.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FWT7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV
60 70 80 90 100
KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD
110 120 130 140 150
IEDEVVEVEN REENLLKISR RVKEYKVEVL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF
310
LELNHKYWER YLSKKQGQ
Length:318
Mass (Da):36,867
Last modified:March 1, 2005 - v1
Checksum:i3CA6BAB10FA44AB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089210 mRNA. Translation: AAH89210.1.
RefSeqiNP_001014139.1. NM_001014117.1.
UniGeneiRn.34113.

Genome annotation databases

EnsembliENSRNOT00000006063; ENSRNOP00000006063; ENSRNOG00000004477.
GeneIDi360514.
KEGGirno:360514.
UCSCiRGD:1310386. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089210 mRNA. Translation: AAH89210.1 .
RefSeqi NP_001014139.1. NM_001014117.1.
UniGenei Rn.34113.

3D structure databases

ProteinModelPortali Q5FWT7.
SMRi Q5FWT7. Positions 3-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 261993. 6 interactions.
STRINGi 10116.ENSRNOP00000006063.

PTM databases

PhosphoSitei Q5FWT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006063 ; ENSRNOP00000006063 ; ENSRNOG00000004477 .
GeneIDi 360514.
KEGGi rno:360514.
UCSCi RGD:1310386. rat.

Organism-specific databases

CTDi 134510.
RGDi 1310386. Ublcp1.

Phylogenomic databases

eggNOGi NOG310886.
GeneTreei ENSGT00390000010107.
HOGENOMi HOG000231279.
HOVERGENi HBG080207.
InParanoidi Q5FWT7.
KOi K17618.
OMAi ELNPPRE.
OrthoDBi EOG74TX01.
PhylomeDBi Q5FWT7.
TreeFami TF323786.

Miscellaneous databases

NextBioi 673039.
PROi Q5FWT7.

Gene expression databases

Genevestigatori Q5FWT7.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiUBCP1_RAT
AccessioniPrimary (citable) accession number: Q5FWT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2005
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3