Q5FWT7 (UBCP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Name:

Ublcp1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: Compara
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ubiquitin-like domain-containing CTD phosphatase 1		PRO_0000242643
Regions
	Domain	3 – 81	79	Ubiquitin-like
	Domain	133 – 294	162	FCP1 homology
	Region	133 – 294	162	Phosphatase By similarity
Amino acid modifications
	Modified residue	117	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FWT7 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 3CA6BAB10FA44AB8	FASTA	318	36,867
	10 20 30 40 50 60 MSLPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK 70 80 90 100 110 120 LGALKLKPNT KIMMMGTREE SLEDVLCPPP DNDDVINDFD IEDEVVEVEN REENLLKISR 130 140 150 160 170 180 RVKEYKVEVL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV 190 200 210 220 230 240 IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS 250 260 270 280 290 300 EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELVKLTQY LKEIAKLDDF 310 LELNHKYWER YLSKKQGQ

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089210 mRNA. Translation: AAH89210.1.
IPI	IPI00372358.
RefSeq	NP_001014139.1. NM_001014117.1.
UniGene	Rn.34113.
3D structure databases
ProteinModelPortal	Q5FWT7.
SMR	Q5FWT7. Positions 3-79.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000006063.
PTM databases
PhosphoSite	Q5FWT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000006063; ENSRNOP00000006063; ENSRNOG00000004477.
GeneID	360514.
KEGG	rno:360514.
UCSC	RGD:1310386. rat.
Organism-specific databases
CTD	134510.
RGD	1310386. Ublcp1.
Phylogenomic databases
eggNOG	NOG310886.
GeneTree	ENSGT00390000010107.
HOGENOM	HOG000231279.
HOVERGEN	HBG080207.
InParanoid	Q5FWT7.
KO	K01090.
OMA	KWIDAKM.
OrthoDB	EOG476K0P.
Gene expression databases
Genevestigator	Q5FWT7.
GermOnline	ENSRNOG00000004477. Rattus norvegicus.
Family and domain databases
Gene3D	3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR011943. HAD-SF_hydro_IIID. IPR004274. NIF. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF03031. NIF. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. SM00213. UBQ. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02245. HAD_IIID1. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	673039.

Entry information

Entry name

UBCP1_RAT

Accession

Primary (citable) accession number: Q5FWT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2005
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program