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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Gene

Qrsl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Charge relay systemUniRule annotation1
Active sitei168Charge relay systemUniRule annotation1
Active sitei192Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-AdT subunit AUniRule annotation
Alternative name(s):
Glutaminyl-tRNA synthase-like protein 1UniRule annotation
Gene namesi
Name:Qrsl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1359490. Qrsl1.

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003167701 – 525Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialAdd BLAST525

Proteomic databases

PaxDbiQ5FWT5.
PRIDEiQ5FWT5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000026049.
GenevisibleiQ5FWT5. RN.

Interactioni

Subunit structurei

Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018891.

Structurei

3D structure databases

ProteinModelPortaliQ5FWT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1211. Eukaryota.
COG0154. LUCA.
GeneTreeiENSGT00550000074866.
HOGENOMiHOG000116699.
HOVERGENiHBG101134.
InParanoidiQ5FWT5.
KOiK02433.
OMAiSKQYRER.
OrthoDBiEOG091G08EM.
PhylomeDBiQ5FWT5.
TreeFamiTF313766.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA. 1 hit.
InterProiIPR000120. Amidase.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 2 hits.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FWT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRTLREVS SALKQGHITP TELCKKCLSL IKKTKYLNAY ITVSEEVALK
60 70 80 90 100
QAEESEKRYK QGQSLGDLDG IPVAVKDNFS TSGIETTCAS NMLKGYLPPY
110 120 130 140 150
NATVVQRLLD QGALLMGKTN LDEFAMGSGS TDGVFGPVKN PWTYSKQYRE
160 170 180 190 200
RSRQDAQEDS HWLITGGSSG GSAAAVAAFT CFAALGSDTG GSTRNPAAHC
210 220 230 240 250
GTVGFKPSYG LVSRHGLIPL VNSMDVPGIF TRCVDDTAIV LGVLAGHDPK
260 270 280 290 300
DSTTVNDPVK PTTLPSVPDV SGLCIGIPKE YLVPELSSEI RSLWSQAADL
310 320 330 340 350
FEAEGARVIE VCLPHTCYSI VCYHVLCTSE VASNMARFDG LQYGHRSAVD
360 370 380 390 400
MSSTEALYAA TRQEGFNDVV KGRILSGNFF LLKENYENYF VKAQKVRRLI
410 420 430 440 450
VNDFVNVFGS GVDVLLTPTT LTQAVPYLEF IKEDNRTRSA QDDIFTQAVN
460 470 480 490 500
MAGLPAVNVP VALSSQGLPI GLQLIGRAFC DQQLLTVAKW FEKQVQFPVI
510 520
QLQDLMDDGS LVPENGKLTS GSLTQ
Length:525
Mass (Da):56,838
Last modified:March 1, 2005 - v1
Checksum:iCF281FD359C8F741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089213 mRNA. Translation: AAH89213.1.
RefSeqiNP_001014056.1. NM_001014034.1.
XP_006256650.1. XM_006256588.3.
UniGeneiRn.116771.

Genome annotation databases

EnsembliENSRNOT00000018892; ENSRNOP00000018891; ENSRNOG00000026049.
GeneIDi309911.
KEGGirno:309911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089213 mRNA. Translation: AAH89213.1.
RefSeqiNP_001014056.1. NM_001014034.1.
XP_006256650.1. XM_006256588.3.
UniGeneiRn.116771.

3D structure databases

ProteinModelPortaliQ5FWT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018891.

Proteomic databases

PaxDbiQ5FWT5.
PRIDEiQ5FWT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018892; ENSRNOP00000018891; ENSRNOG00000026049.
GeneIDi309911.
KEGGirno:309911.

Organism-specific databases

CTDi55278.
RGDi1359490. Qrsl1.

Phylogenomic databases

eggNOGiKOG1211. Eukaryota.
COG0154. LUCA.
GeneTreeiENSGT00550000074866.
HOGENOMiHOG000116699.
HOVERGENiHBG101134.
InParanoidiQ5FWT5.
KOiK02433.
OMAiSKQYRER.
OrthoDBiEOG091G08EM.
PhylomeDBiQ5FWT5.
TreeFamiTF313766.

Miscellaneous databases

PROiQ5FWT5.

Gene expression databases

BgeeiENSRNOG00000026049.
GenevisibleiQ5FWT5. RN.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
HAMAPiMF_00120. GatA. 1 hit.
InterProiIPR000120. Amidase.
IPR023631. Amidase_dom.
IPR004412. GatA.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 2 hits.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
TIGRFAMsiTIGR00132. gatA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGATA_RAT
AccessioniPrimary (citable) accession number: Q5FWT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.