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Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

Gene

Qrsl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei76Charge relay systemUniRule annotation1
Active sitei168Charge relay systemUniRule annotation1
Active sitei192Acyl-ester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialUniRule annotation (EC:6.3.5.7UniRule annotation)
Short name:
Glu-AdT subunit AUniRule annotation
Alternative name(s):
Glutaminyl-tRNA synthase-like protein 1UniRule annotation
Gene namesi
Name:Qrsl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1359490 Qrsl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003167701 – 525Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialAdd BLAST525

Proteomic databases

PaxDbiQ5FWT5
PRIDEiQ5FWT5

Expressioni

Gene expression databases

BgeeiENSRNOG00000026049
GenevisibleiQ5FWT5 RN

Interactioni

Subunit structurei

Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018891

Structurei

3D structure databases

ProteinModelPortaliQ5FWT5
SMRiQ5FWT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family. GatA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1211 Eukaryota
COG0154 LUCA
GeneTreeiENSGT00550000074866
HOGENOMiHOG000116699
HOVERGENiHBG101134
InParanoidiQ5FWT5
KOiK02433
OMAiPITQNVE
OrthoDBiEOG091G08EM
PhylomeDBiQ5FWT5
TreeFamiTF313766

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
HAMAPiMF_00120 GatA, 1 hit
InterProiView protein in InterPro
IPR000120 Amidase
IPR023631 Amidase_dom
IPR036928 AS_sf
IPR004412 GatA
PANTHERiPTHR11895 PTHR11895, 1 hit
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
TIGRFAMsiTIGR00132 gatA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FWT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRTLREVS SALKQGHITP TELCKKCLSL IKKTKYLNAY ITVSEEVALK
60 70 80 90 100
QAEESEKRYK QGQSLGDLDG IPVAVKDNFS TSGIETTCAS NMLKGYLPPY
110 120 130 140 150
NATVVQRLLD QGALLMGKTN LDEFAMGSGS TDGVFGPVKN PWTYSKQYRE
160 170 180 190 200
RSRQDAQEDS HWLITGGSSG GSAAAVAAFT CFAALGSDTG GSTRNPAAHC
210 220 230 240 250
GTVGFKPSYG LVSRHGLIPL VNSMDVPGIF TRCVDDTAIV LGVLAGHDPK
260 270 280 290 300
DSTTVNDPVK PTTLPSVPDV SGLCIGIPKE YLVPELSSEI RSLWSQAADL
310 320 330 340 350
FEAEGARVIE VCLPHTCYSI VCYHVLCTSE VASNMARFDG LQYGHRSAVD
360 370 380 390 400
MSSTEALYAA TRQEGFNDVV KGRILSGNFF LLKENYENYF VKAQKVRRLI
410 420 430 440 450
VNDFVNVFGS GVDVLLTPTT LTQAVPYLEF IKEDNRTRSA QDDIFTQAVN
460 470 480 490 500
MAGLPAVNVP VALSSQGLPI GLQLIGRAFC DQQLLTVAKW FEKQVQFPVI
510 520
QLQDLMDDGS LVPENGKLTS GSLTQ
Length:525
Mass (Da):56,838
Last modified:March 1, 2005 - v1
Checksum:iCF281FD359C8F741
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089213 mRNA Translation: AAH89213.1
RefSeqiNP_001014056.1, NM_001014034.1
XP_006256650.1, XM_006256588.3
UniGeneiRn.116771

Genome annotation databases

EnsembliENSRNOT00000018892; ENSRNOP00000018891; ENSRNOG00000026049
GeneIDi309911
KEGGirno:309911

Similar proteinsi

Entry informationi

Entry nameiGATA_RAT
AccessioniPrimary (citable) accession number: Q5FWT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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