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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Gene

smarcad1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi499 – 5068ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC:3.6.4.12)
Gene namesi
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-492700. smarcad1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10031003SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1PRO_0000420486Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5FWR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 26444CUEPROSITE-ProRule annotationAdd
BLAST
Domaini486 – 654169Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini835 – 997163Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi605 – 6084DEGH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000172362.
HOVERGENiHBG055804.
InParanoidiQ5FWR0.
KOiK14439.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003892. CUE.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51140. CUE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFNLERFR FDKGKKIDTE FGEKGASSRP STPNSQLEDH VTSIPETPEA
60 70 80 90 100
KRVNNPSLFK KDKGVSFLDS DSENEDHQSK SKFSSTHQQS HPREENGTSD
110 120 130 140 150
SVTDDSEDDY LAVKRPSAST AQVKDGSKYK NLQRLKEIFP KQNNDELLKL
160 170 180 190 200
IESTSTLDGA VAAGVVLFNK EGSSRKRKLD EVPKDSSPVH EGINGQTKKK
210 220 230 240 250
KKIDRVSSDN DSSLSEDDWE KQEASVKKLQ RHFPDLDKEE LREVLQEHDW
260 270 280 290 300
SFHEALEALK LFAEDETDAL QNAAKKEVSN GKEFSRSNKN DNKSSAKAKA
310 320 330 340 350
NQNSNKAMAQ NGVKKKGKGK KYSENAKRDT RDLESEESAS DAGSCLDEDY
360 370 380 390 400
SSGDEKLEEE YKTKILSFLQ DASLDELYLI PHCSHKKAQK ITELRPFSSW
410 420 430 440 450
ESLFEKMTKS NGLSEDLIWD CQTLIKEREV VMKLMNKCEE ISRTLTKQVT
460 470 480 490 500
QLTEDGECGW NIEQPSIMSE NLVLKPYQKI GLNWLALLHK HKVNMILADE
510 520 530 540 550
MGLGKTVQAI AFLAHLYVTG DSGPHLVVVP ASTMDNWIRE FNQWCPSMNI
560 570 580 590 600
LLYYGSQEER KHLRYDILNK VVEFNVIVTT YNCAISSAED RSLFRRLKLN
610 620 630 640 650
FAVFDEGHML KNMSAIRYQH LMTLNARSRL LLTGTPVQNN LLELMSLLNF
660 670 680 690 700
VMPHMFSSST SEIKRLFSSK AKSTDEQTIF EKERIAHAKQ IMKPFILRRV
710 720 730 740 750
KSEVLKQLPP KQDKIKFCQM SKKQEQLYSD LLNKLKKSID ATEKNSELCN
760 770 780 790 800
VMMHLRKMAN HPLLHRQYYT ADRLRTMSKL MLKEPTHCDA NPDLIFEDME
810 820 830 840 850
VMTDFELHRL CNEFTTLSQY KLEKELILDS GKFNILEKLL SDIKKKGDRV
860 870 880 890 900
VLFSQFTMML DIIEVFLRHH QHRYVRLDGK TQISERIHLI DEFNTDMDIF
910 920 930 940 950
IFLLSTKAGG LGINLTSANI VILHDIDCNP YNDKQAEDRC HRVGQTKEVK
960 970 980 990 1000
VIKLIGKGTI EESMLKISQQ KLRLEQDMTT NDTGDEGTIP LDMATLLKTS

LGL
Length:1,003
Mass (Da):114,788
Last modified:March 1, 2005 - v1
Checksum:i9A74272E88E1784F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01061573 Genomic DNA. No translation available.
AAMC01061574 Genomic DNA. No translation available.
AAMC01061575 Genomic DNA. No translation available.
BC089242 mRNA. Translation: AAH89242.1.
RefSeqiNP_001015697.1. NM_001015697.1.
UniGeneiStr.34312.

Genome annotation databases

GeneIDi548414.
KEGGixtr:548414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01061573 Genomic DNA. No translation available.
AAMC01061574 Genomic DNA. No translation available.
AAMC01061575 Genomic DNA. No translation available.
BC089242 mRNA. Translation: AAH89242.1.
RefSeqiNP_001015697.1. NM_001015697.1.
UniGeneiStr.34312.

3D structure databases

ProteinModelPortaliQ5FWR0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi548414.
KEGGixtr:548414.

Organism-specific databases

CTDi56916.
XenbaseiXB-GENE-492700. smarcad1.

Phylogenomic databases

HOGENOMiHOG000172362.
HOVERGENiHBG055804.
InParanoidiQ5FWR0.
KOiK14439.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003892. CUE.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51140. CUE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMRCD_XENTR
AccessioniPrimary (citable) accession number: Q5FWR0
Secondary accession number(s): F6W182, F7CJC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: March 1, 2005
Last modified: November 11, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.