Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Gene

smarcad1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 506ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC:3.6.4.12)
Gene namesi
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-492700 smarcad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004204861 – 1003SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1Add BLAST1003

Structurei

3D structure databases

ProteinModelPortaliQ5FWR0
SMRiQ5FWR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 264CUEPROSITE-ProRule annotationAdd BLAST44
Domaini486 – 654Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini835 – 997Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi605 – 608DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

HOGENOMiHOG000172362
HOVERGENiHBG055804
InParanoidiQ5FWR0
KOiK14439

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR003892 CUE
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FWR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFNLERFR FDKGKKIDTE FGEKGASSRP STPNSQLEDH VTSIPETPEA
60 70 80 90 100
KRVNNPSLFK KDKGVSFLDS DSENEDHQSK SKFSSTHQQS HPREENGTSD
110 120 130 140 150
SVTDDSEDDY LAVKRPSAST AQVKDGSKYK NLQRLKEIFP KQNNDELLKL
160 170 180 190 200
IESTSTLDGA VAAGVVLFNK EGSSRKRKLD EVPKDSSPVH EGINGQTKKK
210 220 230 240 250
KKIDRVSSDN DSSLSEDDWE KQEASVKKLQ RHFPDLDKEE LREVLQEHDW
260 270 280 290 300
SFHEALEALK LFAEDETDAL QNAAKKEVSN GKEFSRSNKN DNKSSAKAKA
310 320 330 340 350
NQNSNKAMAQ NGVKKKGKGK KYSENAKRDT RDLESEESAS DAGSCLDEDY
360 370 380 390 400
SSGDEKLEEE YKTKILSFLQ DASLDELYLI PHCSHKKAQK ITELRPFSSW
410 420 430 440 450
ESLFEKMTKS NGLSEDLIWD CQTLIKEREV VMKLMNKCEE ISRTLTKQVT
460 470 480 490 500
QLTEDGECGW NIEQPSIMSE NLVLKPYQKI GLNWLALLHK HKVNMILADE
510 520 530 540 550
MGLGKTVQAI AFLAHLYVTG DSGPHLVVVP ASTMDNWIRE FNQWCPSMNI
560 570 580 590 600
LLYYGSQEER KHLRYDILNK VVEFNVIVTT YNCAISSAED RSLFRRLKLN
610 620 630 640 650
FAVFDEGHML KNMSAIRYQH LMTLNARSRL LLTGTPVQNN LLELMSLLNF
660 670 680 690 700
VMPHMFSSST SEIKRLFSSK AKSTDEQTIF EKERIAHAKQ IMKPFILRRV
710 720 730 740 750
KSEVLKQLPP KQDKIKFCQM SKKQEQLYSD LLNKLKKSID ATEKNSELCN
760 770 780 790 800
VMMHLRKMAN HPLLHRQYYT ADRLRTMSKL MLKEPTHCDA NPDLIFEDME
810 820 830 840 850
VMTDFELHRL CNEFTTLSQY KLEKELILDS GKFNILEKLL SDIKKKGDRV
860 870 880 890 900
VLFSQFTMML DIIEVFLRHH QHRYVRLDGK TQISERIHLI DEFNTDMDIF
910 920 930 940 950
IFLLSTKAGG LGINLTSANI VILHDIDCNP YNDKQAEDRC HRVGQTKEVK
960 970 980 990 1000
VIKLIGKGTI EESMLKISQQ KLRLEQDMTT NDTGDEGTIP LDMATLLKTS

LGL
Length:1,003
Mass (Da):114,788
Last modified:March 1, 2005 - v1
Checksum:i9A74272E88E1784F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01061573 Genomic DNA No translation available.
AAMC01061574 Genomic DNA No translation available.
AAMC01061575 Genomic DNA No translation available.
BC089242 mRNA Translation: AAH89242.1
RefSeqiNP_001015697.1, NM_001015697.1
XP_017948418.1, XM_018092929.1
XP_017948421.1, XM_018092932.1
UniGeneiStr.34312

Genome annotation databases

GeneIDi548414
KEGGixtr:548414

Similar proteinsi

Entry informationi

Entry nameiSMRCD_XENTR
AccessioniPrimary (citable) accession number: Q5FWR0
Secondary accession number(s): F6W182, F7CJC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health