Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5FWM4 (PGAM5_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PGAM5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5
Gene names
Name:pgam5
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Domain

The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane By similarity.

Post-translational modification

Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Sequence caution

The sequence AAH41756.1 differs from that shown. Reason: Frameshift at position 253.

Ontologies

Keywords
   Biological processNecrosis
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processprogrammed cell death

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Serine/threonine-protein phosphatase PGAM5, mitochondrial
PRO_0000288786

Regions

Transmembrane7 – 2418Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5FWM4 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 79FC0F89F205D48E

FASTA27530,986
        10         20         30         40         50         60 
MYLRRALIAG GSAAAAILGV VAAGKSKGGS DSEILSVAPP ATGQWDRNWD RREPISMVNL 

        70         80         90        100        110        120 
SKINAETGEE ELQLHLNKHK PKATRHIFLI RHSQYKLDGK TDFDRVLTPL GREQADLTGQ 

       130        140        150        160        170        180 
RLASLGHKYN HIVYSTMTRA KETTEIISKY LPDVNKSSSD LLREGAPIRP EPQVCHWKPD 

       190        200        210        220        230        240 
FVYYEDGPRI EAAFRHFIHR ADPKQEEDSY EILICHANVI RYVVCRALQF PPEAWLRISL 

       250        260        270 
NNGSITYLVI RPNGNVSIRM LGDSGFMPAE KISRT 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Egg and Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC041756 mRNA. Translation: AAH41756.1. Frameshift.
BC089282 mRNA. Translation: AAH89282.1.
RefSeqNP_001082456.1. NM_001088987.1.
UniGeneXl.15183.

3D structure databases

ProteinModelPortalQ5FWM4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398484.
KEGGxla:398484.

Organism-specific databases

CTD192111.
XenbaseXB-GENE-6256307. pgam5.

Phylogenomic databases

HOVERGENHBG105576.
KOK15637.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGAM5_XENLA
AccessionPrimary (citable) accession number: Q5FWM4
Secondary accession number(s): Q8AVL5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2005
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families