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Q5FWM4

- PGAM5_XENLA

UniProt

Q5FWM4 - PGAM5_XENLA

Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene

pgam5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. programmed cell death Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Necrosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5
    Gene namesi
    Name:pgam5
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6256307. pgam5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Serine/threonine-protein phosphatase PGAM5, mitochondrialPRO_0000288786Add
    BLAST

    Post-translational modificationi

    Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FWM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2418HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG105576.
    KOiK15637.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FWM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLRRALIAG GSAAAAILGV VAAGKSKGGS DSEILSVAPP ATGQWDRNWD    50
    RREPISMVNL SKINAETGEE ELQLHLNKHK PKATRHIFLI RHSQYKLDGK 100
    TDFDRVLTPL GREQADLTGQ RLASLGHKYN HIVYSTMTRA KETTEIISKY 150
    LPDVNKSSSD LLREGAPIRP EPQVCHWKPD FVYYEDGPRI EAAFRHFIHR 200
    ADPKQEEDSY EILICHANVI RYVVCRALQF PPEAWLRISL NNGSITYLVI 250
    RPNGNVSIRM LGDSGFMPAE KISRT 275
    Length:275
    Mass (Da):30,986
    Last modified:March 1, 2005 - v1
    Checksum:i79FC0F89F205D48E
    GO

    Sequence cautioni

    The sequence AAH41756.1 differs from that shown. Reason: Frameshift at position 253.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC041756 mRNA. Translation: AAH41756.1. Frameshift.
    BC089282 mRNA. Translation: AAH89282.1.
    RefSeqiNP_001082456.1. NM_001088987.1.
    UniGeneiXl.15183.

    Genome annotation databases

    GeneIDi398484.
    KEGGixla:398484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC041756 mRNA. Translation: AAH41756.1 . Frameshift.
    BC089282 mRNA. Translation: AAH89282.1 .
    RefSeqi NP_001082456.1. NM_001088987.1.
    UniGenei Xl.15183.

    3D structure databases

    ProteinModelPortali Q5FWM4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398484.
    KEGGi xla:398484.

    Organism-specific databases

    CTDi 192111.
    Xenbasei XB-GENE-6256307. pgam5.

    Phylogenomic databases

    HOVERGENi HBG105576.
    KOi K15637.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg and Embryo.

    Entry informationi

    Entry nameiPGAM5_XENLA
    AccessioniPrimary (citable) accession number: Q5FWM4
    Secondary accession number(s): Q8AVL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3