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Protein

Rho GTPase-activating protein 1

Gene

Arhgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei282Involved in G-protein binding to GAPsBy similarity1

GO - Molecular functioni

GO - Biological processi

  • regulation of GTPase activity Source: MGI
  • small GTPase mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 1
Alternative name(s):
Rho-type GTPase-activating protein 1
Gene namesi
Name:Arhgap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445003. Arhgap1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cell leading edge Source: MGI
  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • plasma membrane Source: MGI
  • ruffle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236071 – 439Rho GTPase-activating protein 1Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei65PhosphotyrosineCombined sources1
Modified residuei80N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5FWK3.
MaxQBiQ5FWK3.
PaxDbiQ5FWK3.
PeptideAtlasiQ5FWK3.
PRIDEiQ5FWK3.

PTM databases

iPTMnetiQ5FWK3.
PhosphoSitePlusiQ5FWK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027247.
CleanExiMM_ARHGAP1.
ExpressionAtlasiQ5FWK3. baseline and differential.
GenevisibleiQ5FWK3. MM.

Interactioni

Subunit structurei

Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230727. 6 interactors.
STRINGi10090.ENSMUSP00000106963.

Structurei

3D structure databases

ProteinModelPortaliQ5FWK3.
SMRiQ5FWK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 218CRAL-TRIOPROSITE-ProRule annotationAdd BLAST156
Domaini244 – 431Rho-GAPPROSITE-ProRule annotationAdd BLAST188

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi228 – 238SH3-bindingBy similarityAdd BLAST11

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000231442.
HOVERGENiHBG054433.
InParanoidiQ5FWK3.
KOiK18470.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLSELQDD LTLDDTSQAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS
60 70 80 90 100
SPEPVTHLKW DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD
110 120 130 140 150
HSKLLGYLKH TLDQYVESDY TLLYLHHGLT SDNKPSLSWL RDAYREFDRK
160 170 180 190 200
YKKNIKALYI VHPTMFIKTL LILFKPLISF KFGRKIFYVN YLSELSEHVK
210 220 230 240 250
LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ QFGVSLQHLQ
260 270 280 290 300
EKSPGQDPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG
310 320 330 340 350
LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV
360 370 380 390 400
EVTQQVLQTL PEENYQVLHF LTAFLVQISA HCDQNKMTNT NLAVVFGPNL
410 420 430
LWAKDAAITL KAINPINTFT KFLLDHQGEL FPSTDAQGV
Length:439
Mass (Da):50,411
Last modified:March 1, 2005 - v1
Checksum:iD8FD1E14C6BE32D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168K → Q in BAC39233 (PubMed:16141072).Curated1
Sequence conflicti257D → E in AAH06592 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084622 mRNA. Translation: BAC39233.1.
AL714023, AL691489 Genomic DNA. Translation: CAM14522.1.
BC006592 mRNA. Translation: AAH06592.1.
BC089306 mRNA. Translation: AAH89306.1.
CCDSiCCDS16437.1.
RefSeqiNP_001139374.1. NM_001145902.1.
NP_666236.3. NM_146124.4.
XP_006499307.1. XM_006499244.1.
XP_006499308.1. XM_006499245.3.
XP_006499309.1. XM_006499246.3.
XP_006499310.1. XM_006499247.2.
XP_006499311.1. XM_006499248.2.
XP_006499312.1. XM_006499249.2.
XP_006499313.1. XM_006499250.1.
XP_011237759.1. XM_011239457.1.
UniGeneiMm.22413.

Genome annotation databases

EnsembliENSMUST00000090614; ENSMUSP00000088105; ENSMUSG00000027247.
ENSMUST00000111329; ENSMUSP00000106961; ENSMUSG00000027247.
ENSMUST00000111330; ENSMUSP00000106962; ENSMUSG00000027247.
GeneIDi228359.
KEGGimmu:228359.
UCSCiuc008kwi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084622 mRNA. Translation: BAC39233.1.
AL714023, AL691489 Genomic DNA. Translation: CAM14522.1.
BC006592 mRNA. Translation: AAH06592.1.
BC089306 mRNA. Translation: AAH89306.1.
CCDSiCCDS16437.1.
RefSeqiNP_001139374.1. NM_001145902.1.
NP_666236.3. NM_146124.4.
XP_006499307.1. XM_006499244.1.
XP_006499308.1. XM_006499245.3.
XP_006499309.1. XM_006499246.3.
XP_006499310.1. XM_006499247.2.
XP_006499311.1. XM_006499248.2.
XP_006499312.1. XM_006499249.2.
XP_006499313.1. XM_006499250.1.
XP_011237759.1. XM_011239457.1.
UniGeneiMm.22413.

3D structure databases

ProteinModelPortaliQ5FWK3.
SMRiQ5FWK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230727. 6 interactors.
STRINGi10090.ENSMUSP00000106963.

PTM databases

iPTMnetiQ5FWK3.
PhosphoSitePlusiQ5FWK3.

Proteomic databases

EPDiQ5FWK3.
MaxQBiQ5FWK3.
PaxDbiQ5FWK3.
PeptideAtlasiQ5FWK3.
PRIDEiQ5FWK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090614; ENSMUSP00000088105; ENSMUSG00000027247.
ENSMUST00000111329; ENSMUSP00000106961; ENSMUSG00000027247.
ENSMUST00000111330; ENSMUSP00000106962; ENSMUSG00000027247.
GeneIDi228359.
KEGGimmu:228359.
UCSCiuc008kwi.2. mouse.

Organism-specific databases

CTDi392.
MGIiMGI:2445003. Arhgap1.

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
GeneTreeiENSGT00420000029688.
HOGENOMiHOG000231442.
HOVERGENiHBG054433.
InParanoidiQ5FWK3.
KOiK18470.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ5FWK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027247.
CleanExiMM_ARHGAP1.
ExpressionAtlasiQ5FWK3. baseline and differential.
GenevisibleiQ5FWK3. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG01_MOUSE
AccessioniPrimary (citable) accession number: Q5FWK3
Secondary accession number(s): Q8C3X5, Q923D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.