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Protein

Rho GTPase-activating protein 1

Gene

Arhgap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei282Involved in G-protein binding to GAPsBy similarity1

GO - Molecular functioni

  • cadherin binding Source: MGI
  • GTPase activator activity Source: MGI
  • Rab GTPase binding Source: MGI
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 1
Alternative name(s):
Rho-type GTPase-activating protein 1
Gene namesi
Name:Arhgap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445003 Arhgap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236071 – 439Rho GTPase-activating protein 1Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei65PhosphotyrosineCombined sources1
Modified residuei80N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5FWK3
MaxQBiQ5FWK3
PaxDbiQ5FWK3
PeptideAtlasiQ5FWK3
PRIDEiQ5FWK3

PTM databases

iPTMnetiQ5FWK3
PhosphoSitePlusiQ5FWK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000027247
CleanExiMM_ARHGAP1
ExpressionAtlasiQ5FWK3 baseline and differential
GenevisibleiQ5FWK3 MM

Interactioni

Subunit structurei

Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230727, 6 interactors
STRINGi10090.ENSMUSP00000106963

Structurei

3D structure databases

ProteinModelPortaliQ5FWK3
SMRiQ5FWK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 218CRAL-TRIOPROSITE-ProRule annotationAdd BLAST156
Domaini244 – 431Rho-GAPPROSITE-ProRule annotationAdd BLAST188

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi228 – 238SH3-bindingBy similarityAdd BLAST11

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4406 Eukaryota
ENOG410XR4J LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000231442
HOVERGENiHBG054433
InParanoidiQ5FWK3
KOiK18470

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di1.10.555.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FWK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLSELQDD LTLDDTSQAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS
60 70 80 90 100
SPEPVTHLKW DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD
110 120 130 140 150
HSKLLGYLKH TLDQYVESDY TLLYLHHGLT SDNKPSLSWL RDAYREFDRK
160 170 180 190 200
YKKNIKALYI VHPTMFIKTL LILFKPLISF KFGRKIFYVN YLSELSEHVK
210 220 230 240 250
LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ QFGVSLQHLQ
260 270 280 290 300
EKSPGQDPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG
310 320 330 340 350
LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV
360 370 380 390 400
EVTQQVLQTL PEENYQVLHF LTAFLVQISA HCDQNKMTNT NLAVVFGPNL
410 420 430
LWAKDAAITL KAINPINTFT KFLLDHQGEL FPSTDAQGV
Length:439
Mass (Da):50,411
Last modified:March 1, 2005 - v1
Checksum:iD8FD1E14C6BE32D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168K → Q in BAC39233 (PubMed:16141072).Curated1
Sequence conflicti257D → E in AAH06592 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084622 mRNA Translation: BAC39233.1
AL714023, AL691489 Genomic DNA Translation: CAM14522.1
BC006592 mRNA Translation: AAH06592.1
BC089306 mRNA Translation: AAH89306.1
CCDSiCCDS16437.1
RefSeqiNP_001139374.1, NM_001145902.1
NP_666236.3, NM_146124.4
XP_006499307.1, XM_006499244.1
XP_006499308.1, XM_006499245.3
XP_006499309.1, XM_006499246.3
XP_006499310.1, XM_006499247.2
XP_006499311.1, XM_006499248.2
XP_006499312.1, XM_006499249.2
XP_006499313.1, XM_006499250.1
XP_011237759.1, XM_011239457.1
UniGeneiMm.22413

Genome annotation databases

EnsembliENSMUST00000090614; ENSMUSP00000088105; ENSMUSG00000027247
ENSMUST00000111329; ENSMUSP00000106961; ENSMUSG00000027247
ENSMUST00000111330; ENSMUSP00000106962; ENSMUSG00000027247
GeneIDi228359
KEGGimmu:228359
UCSCiuc008kwi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRHG01_MOUSE
AccessioniPrimary (citable) accession number: Q5FWK3
Secondary accession number(s): Q8C3X5, Q923D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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