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Protein

Secretin receptor

Gene

Sctr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2441720. Sctr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 142114ExtracellularSequence analysisAdd
BLAST
Transmembranei143 – 16624Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini167 – 1737CytoplasmicSequence analysis
Transmembranei174 – 19320Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini194 – 21522ExtracellularSequence analysisAdd
BLAST
Transmembranei216 – 23924Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini240 – 25314CytoplasmicSequence analysisAdd
BLAST
Transmembranei254 – 27522Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini276 – 29318ExtracellularSequence analysisAdd
BLAST
Transmembranei294 – 31623Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini317 – 34226CytoplasmicSequence analysisAdd
BLAST
Transmembranei343 – 36119Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini362 – 3687ExtracellularSequence analysis
Transmembranei369 – 39123Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini392 – 44756CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 447419Secretin receptorPRO_0000043222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FWI2.
PRIDEiQ5FWI2.

Expressioni

Gene expression databases

BgeeiQ5FWI2.
CleanExiMM_SCTR.
ExpressionAtlasiQ5FWI2. baseline and differential.
GenevisibleiQ5FWI2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072660.

Structurei

3D structure databases

ProteinModelPortaliQ5FWI2.
SMRiQ5FWI2. Positions 44-123, 141-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ5FWI2.
KOiK04588.
PhylomeDBiQ5FWI2.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FWI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTMSPRLS LLLLWLLLLI NAAHPVGALP RLCDVRRVLL EERAECLREL
60 70 80 90 100
SEEKKALGPK TASGCERFWD NMSCWPSSAL AQTVEVPCPK FLRMFSGRNG
110 120 130 140 150
SLFRNCTKDG WSETFPRPDL ACGVNMNGSF NERRHAYLLK LKVMYTVGYS
160 170 180 190 200
SSLAMLLVAL SILCSFRRLH CTRNYIHMHL FVSFILRALS NFIKDAVLFP
210 220 230 240 250
ADDVTYCDAH RAGCKLVMIF FQYCIMANYA WLLVEGLYLH TLLAISFFSE
260 270 280 290 300
RKCLQAFVLF GWGSPAIFVA LWAVTRHFLE DFGCWDINSN ASIWWVIRGP
310 320 330 340 350
VILSIVINFI FFINILRILM RKLRTQETRG NETHHYKRLA KSTLLLIPLF
360 370 380 390 400
GIHYIVFAFS PEGAMEVQLF FELALGSFQG LVVAVLYCFL NGELEVQKKW
410 420 430 440
RQWHLQEFPL RPVALSNSFS NATNGPTHST KAGTSEQSRS IPGANVI
Length:447
Mass (Da):50,932
Last modified:March 1, 2005 - v1
Checksum:iDD937AFC33D41115
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089355 mRNA. Translation: AAH89355.1.
AY255623 mRNA. Translation: AAO85135.1.
CCDSiCCDS78668.1.
RefSeqiNP_001012322.2. NM_001012322.2.
NP_001298006.1. NM_001311077.1.
UniGeneiMm.189223.

Genome annotation databases

EnsembliENSMUST00000189037; ENSMUSP00000139932; ENSMUSG00000026387.
GeneIDi319229.
KEGGimmu:319229.
UCSCiuc007cjc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089355 mRNA. Translation: AAH89355.1.
AY255623 mRNA. Translation: AAO85135.1.
CCDSiCCDS78668.1.
RefSeqiNP_001012322.2. NM_001012322.2.
NP_001298006.1. NM_001311077.1.
UniGeneiMm.189223.

3D structure databases

ProteinModelPortaliQ5FWI2.
SMRiQ5FWI2. Positions 44-123, 141-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072660.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ5FWI2.
PRIDEiQ5FWI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000189037; ENSMUSP00000139932; ENSMUSG00000026387.
GeneIDi319229.
KEGGimmu:319229.
UCSCiuc007cjc.1. mouse.

Organism-specific databases

CTDi6344.
MGIiMGI:2441720. Sctr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ5FWI2.
KOiK04588.
PhylomeDBiQ5FWI2.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

NextBioi394424.
PROiQ5FWI2.
SOURCEiSearch...

Gene expression databases

BgeeiQ5FWI2.
CleanExiMM_SCTR.
ExpressionAtlasiQ5FWI2. baseline and differential.
GenevisibleiQ5FWI2. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR002144. GPCR_2_secretin_rcpt.
[Graphical view]
PANTHERiPTHR12011:SF29. PTHR12011:SF29. 1 hit.
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR00490. SECRETINR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-360.

Entry informationi

Entry nameiSCTR_MOUSE
AccessioniPrimary (citable) accession number: Q5FWI2
Secondary accession number(s): Q80T66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2005
Last modified: January 20, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.