Unreviewed,
UniProtKB/TrEMBL Q5FWG5 (Q5FWG5_HUMAN)
Last modified
January 19, 2010.
Version 40.
History...
Clusters with 100%,
90%,
50% identity |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information
Names and origin
| Protein names | Submitted name: Toll-like receptor 1 EMBL AAH89403.1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) EMBL AAH89403.1 | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 786 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Leucine-rich repeat Spearmint SPM000483 Repeat Spearmint SPM000483 Transmembrane Spearmint SPM004075 |
| Molecular function | Receptor EMBL AAH89403.1 |
| Gene Ontology (GO) | |
| Biological process | I-kappaB kinase/NF-kappaB cascade Inferred from Experiment. Source: Reactome innate immune responseInferred from electronic annotation. Source: InterPro positive regulation of interleukin-6 biosynthetic processInferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor biosynthetic processInferred from electronic annotation. Source: Compara |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from Experiment. Source: Reactome |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro transmembrane receptor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequences
| ||||||||||||||||||
References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph EMBL AAH89403.1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC089403 mRNA. Translation: AAH89403.1. |
| IPI | IPI00090764. |
| UniGene | Hs.621817 Hs.654532 |
3D structure databases | |
| SMR | Q5FWG5. Positions 25-549, 27-618, 625-785. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5FWG5. |
Genome annotation databases | |
| Ensembl | ENST00000308979; ENSP00000354932; ENSG00000174125; Homo sapiens. [Genome view] |
Organism-specific databases | |
| HGNC | HGNC:11847. TLR1. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q5FWG5. |
Enzyme and pathway databases | |
| Reactome | REACT_6900. Signaling in Immune system. |
Gene expression databases | |
| ArrayExpress | Q5FWG5. |
| Bgee | Q5FWG5. |
Family and domain databases | |
| InterPro | IPR000483. Cys-rich_flank_reg_C. IPR004075. IL1_rcpt_1. IPR001611. Leu-rich_rpt. IPR000157. Toll-Interleukin_rcpt. IPR017241. Toll-like_receptor. [Graphical view] |
| Pfam | PF00560. LRR_1. 1 hit. PF01582. TIR. 1 hit. [Graphical view] |
| PIRSF | PIRSF037595. Toll-like_receptor. 1 hit. |
| PRINTS | PR01537. INTRLKN1R1F. |
| SMART | SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view] |
| PROSITE | PS50104. TIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | Q5FWG5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q5FWG5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
