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Protein

F-box only protein 48

Gene

FBXO48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 48
Gene namesi
Name:FBXO48
Synonyms:FBX48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33857. FBXO48.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204923.
PharmGKBiPA162388158.

Polymorphism and mutation databases

BioMutaiFBXO48.
DMDMi74755340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003356771 – 155F-box only protein 48Add BLAST155

Proteomic databases

EPDiQ5FWF7.
MaxQBiQ5FWF7.
PaxDbiQ5FWF7.
PeptideAtlasiQ5FWF7.
PRIDEiQ5FWF7.

PTM databases

iPTMnetiQ5FWF7.
PhosphoSitePlusiQ5FWF7.

Expressioni

Gene expression databases

BgeeiENSG00000204923.
CleanExiHS_FBXO48.

Organism-specific databases

HPAiHPA049775.
HPA054782.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P632086EBI-11961122,EBI-307486

Protein-protein interaction databases

IntActiQ5FWF7. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ5FWF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 79F-boxPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410IX69. Eukaryota.
ENOG41125II. LUCA.
GeneTreeiENSGT00390000012248.
HOGENOMiHOG000007150.
HOVERGENiHBG094843.
InParanoidiQ5FWF7.
OMAiLPEKIMY.
OrthoDBiEOG091G1A1M.
PhylomeDBiQ5FWF7.
TreeFamiTF332573.

Family and domain databases

InterProiView protein in InterPro
IPR001810. F-box_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FWF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKNSKRNNN LRVSHTEANS VDAEKEKNES QNNFFELLPA EITFKIFSQL
60 70 80 90 100
DIRSLCRASL TCRSWNDTIR NSDSLWKPHC MTVRAVCRRE IDDDLESGYS
110 120 130 140 150
WRVILLRNYQ KSKVKHEWLS GRYSNICSPI SLPEKIMYPM DADTWGEILE

AELER
Length:155
Mass (Da):18,241
Last modified:March 1, 2005 - v1
Checksum:i135851156496E816
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04346616T → I. Corresponds to variant dbSNP:rs12614904Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ904332 mRNA. Translation: ABI98402.1.
BC089423 mRNA. Translation: AAH89423.1.
CCDSiCCDS33213.1.
RefSeqiNP_001019851.1. NM_001024680.2.
XP_005264464.1. XM_005264407.2.
XP_016859926.1. XM_017004437.1.
UniGeneiHs.164117.

Genome annotation databases

EnsembliENST00000377957; ENSP00000367193; ENSG00000204923.
GeneIDi554251.
KEGGihsa:554251.
UCSCiuc002seo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ904332 mRNA. Translation: ABI98402.1.
BC089423 mRNA. Translation: AAH89423.1.
CCDSiCCDS33213.1.
RefSeqiNP_001019851.1. NM_001024680.2.
XP_005264464.1. XM_005264407.2.
XP_016859926.1. XM_017004437.1.
UniGeneiHs.164117.

3D structure databases

ProteinModelPortaliQ5FWF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5FWF7. 1 interactor.

PTM databases

iPTMnetiQ5FWF7.
PhosphoSitePlusiQ5FWF7.

Polymorphism and mutation databases

BioMutaiFBXO48.
DMDMi74755340.

Proteomic databases

EPDiQ5FWF7.
MaxQBiQ5FWF7.
PaxDbiQ5FWF7.
PeptideAtlasiQ5FWF7.
PRIDEiQ5FWF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377957; ENSP00000367193; ENSG00000204923.
GeneIDi554251.
KEGGihsa:554251.
UCSCiuc002seo.5. human.

Organism-specific databases

CTDi554251.
GeneCardsiFBXO48.
HGNCiHGNC:33857. FBXO48.
HPAiHPA049775.
HPA054782.
neXtProtiNX_Q5FWF7.
OpenTargetsiENSG00000204923.
PharmGKBiPA162388158.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX69. Eukaryota.
ENOG41125II. LUCA.
GeneTreeiENSGT00390000012248.
HOGENOMiHOG000007150.
HOVERGENiHBG094843.
InParanoidiQ5FWF7.
OMAiLPEKIMY.
OrthoDBiEOG091G1A1M.
PhylomeDBiQ5FWF7.
TreeFamiTF332573.

Miscellaneous databases

GenomeRNAii554251.
PROiPR:Q5FWF7.

Gene expression databases

BgeeiENSG00000204923.
CleanExiHS_FBXO48.

Family and domain databases

InterProiView protein in InterPro
IPR001810. F-box_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX48_HUMAN
AccessioniPrimary (citable) accession number: Q5FWF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2005
Last modified: April 12, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.