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Protein

F-box only protein 48

Gene

FBXO48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 48
Gene namesi
Name:FBXO48
Synonyms:FBX48
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33857. FBXO48.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388158.

Polymorphism and mutation databases

BioMutaiFBXO48.
DMDMi74755340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155F-box only protein 48PRO_0000335677Add
BLAST

Proteomic databases

MaxQBiQ5FWF7.
PaxDbiQ5FWF7.
PRIDEiQ5FWF7.

PTM databases

PhosphoSiteiQ5FWF7.

Expressioni

Gene expression databases

BgeeiQ5FWF7.
CleanExiHS_FBXO48.

Organism-specific databases

HPAiHPA049775.

Structurei

3D structure databases

ProteinModelPortaliQ5FWF7.
SMRiQ5FWF7. Positions 32-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 7948F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX69. Eukaryota.
ENOG41125II. LUCA.
GeneTreeiENSGT00390000012248.
HOGENOMiHOG000007150.
HOVERGENiHBG094843.
InParanoidiQ5FWF7.
OMAiLPEKIMY.
OrthoDBiEOG7PCJK2.
PhylomeDBiQ5FWF7.
TreeFamiTF332573.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FWF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKNSKRNNN LRVSHTEANS VDAEKEKNES QNNFFELLPA EITFKIFSQL
60 70 80 90 100
DIRSLCRASL TCRSWNDTIR NSDSLWKPHC MTVRAVCRRE IDDDLESGYS
110 120 130 140 150
WRVILLRNYQ KSKVKHEWLS GRYSNICSPI SLPEKIMYPM DADTWGEILE

AELER
Length:155
Mass (Da):18,241
Last modified:March 1, 2005 - v1
Checksum:i135851156496E816
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161T → I.
Corresponds to variant rs12614904 [ dbSNP | Ensembl ].
VAR_043466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ904332 mRNA. Translation: ABI98402.1.
BC089423 mRNA. Translation: AAH89423.1.
CCDSiCCDS33213.1.
RefSeqiNP_001019851.1. NM_001024680.2.
XP_005264464.1. XM_005264407.1.
UniGeneiHs.164117.

Genome annotation databases

EnsembliENST00000377957; ENSP00000367193; ENSG00000204923.
GeneIDi554251.
KEGGihsa:554251.
UCSCiuc002seo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ904332 mRNA. Translation: ABI98402.1.
BC089423 mRNA. Translation: AAH89423.1.
CCDSiCCDS33213.1.
RefSeqiNP_001019851.1. NM_001024680.2.
XP_005264464.1. XM_005264407.1.
UniGeneiHs.164117.

3D structure databases

ProteinModelPortaliQ5FWF7.
SMRiQ5FWF7. Positions 32-108.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ5FWF7.

Polymorphism and mutation databases

BioMutaiFBXO48.
DMDMi74755340.

Proteomic databases

MaxQBiQ5FWF7.
PaxDbiQ5FWF7.
PRIDEiQ5FWF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377957; ENSP00000367193; ENSG00000204923.
GeneIDi554251.
KEGGihsa:554251.
UCSCiuc002seo.5. human.

Organism-specific databases

CTDi554251.
GeneCardsiFBXO48.
HGNCiHGNC:33857. FBXO48.
HPAiHPA049775.
neXtProtiNX_Q5FWF7.
PharmGKBiPA162388158.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX69. Eukaryota.
ENOG41125II. LUCA.
GeneTreeiENSGT00390000012248.
HOGENOMiHOG000007150.
HOVERGENiHBG094843.
InParanoidiQ5FWF7.
OMAiLPEKIMY.
OrthoDBiEOG7PCJK2.
PhylomeDBiQ5FWF7.
TreeFamiTF332573.

Miscellaneous databases

GenomeRNAii554251.
NextBioi112469.
PROiQ5FWF7.

Gene expression databases

BgeeiQ5FWF7.
CleanExiHS_FBXO48.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human F-box only 48 (FBXO48)."
    Corcoran M.M., Cepeda D., Akhondi S., Spruck C., Sangfelt O.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.

Entry informationi

Entry nameiFBX48_HUMAN
AccessioniPrimary (citable) accession number: Q5FWF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2005
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.