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Protein

Zinc finger protein 789

Gene

ZNF789

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33506-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 789
Gene namesi
Name:ZNF789
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:27801. ZNF789.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198556.
PharmGKBiPA162410492.

Polymorphism and mutation databases

BioMutaiZNF789.
DMDMi152112419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002936971 – 425Zinc finger protein 789Add BLAST425

Proteomic databases

EPDiQ5FWF6.
MaxQBiQ5FWF6.
PaxDbiQ5FWF6.
PeptideAtlasiQ5FWF6.
PRIDEiQ5FWF6.

PTM databases

iPTMnetiQ5FWF6.
PhosphoSitePlusiQ5FWF6.

Expressioni

Gene expression databases

BgeeiENSG00000198556.
CleanExiHS_ZNF789.
ExpressionAtlasiQ5FWF6. baseline and differential.
GenevisibleiQ5FWF6. HS.

Organism-specific databases

HPAiHPA029500.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331927.

Structurei

3D structure databases

ProteinModelPortaliQ5FWF6.
SMRiQ5FWF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 82KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133845.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5FWF6.
OMAiGQAFKQK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5FWF6.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5FWF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPPARGKEL LSFEDVAMYF TREEWGHLNW GQKDLYRDVM LENYRNMVLL
60 70 80 90 100
GFQFPKPEMI CQLENWDEQW ILDLPRTGNR KASGSACPGS EARHKMKKLT
110 120 130 140 150
PKQKFSEDLE SYKISVVMQE SAEKLSEKLH KCKEFVDSCR LTFPTSGDEY
160 170 180 190 200
SRGFLQNLNL IQDQNAQTRW KQGRYDEDGK PFNQRSLLLG HERILTRAKS
210 220 230 240 250
YECSECGKVI RRKAWFDQHQ RIHFLENPFE CKVCGQAFRQ RSALTVHKQC
260 270 280 290 300
HLQNKPYRCH DCGKCFRQLA YLVEHKRIHT KEKPYKCSKC EKTFSQNSTL
310 320 330 340 350
IRHQVIHSGE KRHKCLECGK AFGRHSTLLC HQQIHSKPNT HKCSECGQSF
360 370 380 390 400
GRNVDLIQHQ RIHTKEEFFQ CGECGKTFSF KRNLFRHQVI HTGSQPYQCV
410 420
ICGKSFKWHT SFIKHQGTHK GQIST
Length:425
Mass (Da):49,984
Last modified:July 10, 2007 - v3
Checksum:i00BF9778A9340CFA
GO
Isoform 2 (identifier: Q5FWF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:330
Mass (Da):38,779
Checksum:iC08FB0A7388A5A17
GO
Isoform 3 (identifier: Q5FWF6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-62: GFQFPKPEMICQ → VYFQFDAAIPLC
     63-425: Missing.

Note: Gene prediction based on EST data.
Show »
Length:62
Mass (Da):7,480
Checksum:i89FF1A5E271E39A5
GO

Sequence cautioni

Isoform 2 : The sequence BAD18576 differs from that shown. Reason: Frameshift at positions 85 and 271.Curated
The sequence EAL23876 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti398Q → R in BAD18576 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05290377T → A.1 PublicationCorresponds to variant rs6962772dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265611 – 95Missing in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_04681651 – 62GFQFP…EMICQ → VYFQFDAAIPLC in isoform 3. CuratedAdd BLAST12
Alternative sequenceiVSP_04681763 – 425Missing in isoform 3. CuratedAdd BLAST363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131429 mRNA. Translation: BAD18576.1. Frameshift.
AC073063 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23875.1.
CH236956 Genomic DNA. Translation: EAL23876.1. Sequence problems.
BC089424 mRNA. Translation: AAH89424.2.
CCDSiCCDS34693.1. [Q5FWF6-1]
CCDS34694.1. [Q5FWF6-3]
RefSeqiNP_001013276.1. NM_001013258.1. [Q5FWF6-3]
NP_998768.2. NM_213603.2. [Q5FWF6-1]
XP_011514375.1. XM_011516073.2. [Q5FWF6-2]
XP_016867507.1. XM_017012018.1. [Q5FWF6-1]
XP_016867514.1. XM_017012025.1. [Q5FWF6-2]
XP_016867515.1. XM_017012026.1. [Q5FWF6-2]
XP_016867516.1. XM_017012027.1. [Q5FWF6-2]
UniGeneiHs.440384.

Genome annotation databases

EnsembliENST00000331410; ENSP00000331927; ENSG00000198556. [Q5FWF6-1]
ENST00000379724; ENSP00000369047; ENSG00000198556. [Q5FWF6-3]
GeneIDi285989.
KEGGihsa:285989.
UCSCiuc003uqp.4. human. [Q5FWF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131429 mRNA. Translation: BAD18576.1. Frameshift.
AC073063 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23875.1.
CH236956 Genomic DNA. Translation: EAL23876.1. Sequence problems.
BC089424 mRNA. Translation: AAH89424.2.
CCDSiCCDS34693.1. [Q5FWF6-1]
CCDS34694.1. [Q5FWF6-3]
RefSeqiNP_001013276.1. NM_001013258.1. [Q5FWF6-3]
NP_998768.2. NM_213603.2. [Q5FWF6-1]
XP_011514375.1. XM_011516073.2. [Q5FWF6-2]
XP_016867507.1. XM_017012018.1. [Q5FWF6-1]
XP_016867514.1. XM_017012025.1. [Q5FWF6-2]
XP_016867515.1. XM_017012026.1. [Q5FWF6-2]
XP_016867516.1. XM_017012027.1. [Q5FWF6-2]
UniGeneiHs.440384.

3D structure databases

ProteinModelPortaliQ5FWF6.
SMRiQ5FWF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331927.

PTM databases

iPTMnetiQ5FWF6.
PhosphoSitePlusiQ5FWF6.

Polymorphism and mutation databases

BioMutaiZNF789.
DMDMi152112419.

Proteomic databases

EPDiQ5FWF6.
MaxQBiQ5FWF6.
PaxDbiQ5FWF6.
PeptideAtlasiQ5FWF6.
PRIDEiQ5FWF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331410; ENSP00000331927; ENSG00000198556. [Q5FWF6-1]
ENST00000379724; ENSP00000369047; ENSG00000198556. [Q5FWF6-3]
GeneIDi285989.
KEGGihsa:285989.
UCSCiuc003uqp.4. human. [Q5FWF6-1]

Organism-specific databases

CTDi285989.
GeneCardsiZNF789.
HGNCiHGNC:27801. ZNF789.
HPAiHPA029500.
neXtProtiNX_Q5FWF6.
OpenTargetsiENSG00000198556.
PharmGKBiPA162410492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133845.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ5FWF6.
OMAiGQAFKQK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ5FWF6.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:G66-33506-MONOMER.

Miscellaneous databases

ChiTaRSiZNF789. human.
GenomeRNAii285989.
PROiQ5FWF6.

Gene expression databases

BgeeiENSG00000198556.
CleanExiHS_ZNF789.
ExpressionAtlasiQ5FWF6. baseline and differential.
GenevisibleiQ5FWF6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN789_HUMAN
AccessioniPrimary (citable) accession number: Q5FWF6
Secondary accession number(s): A4D282, A6NH61, Q6ZMZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.