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Protein

Proline-rich transmembrane protein 3

Gene

PRRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich transmembrane protein 3
Gene namesi
Name:PRRT3
ORF Names:UNQ5823/PRO19642
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26591. PRRT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 474ExtracellularSequence analysisAdd BLAST447
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Topological domaini496 – 501CytoplasmicSequence analysis6
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 542ExtracellularSequence analysisAdd BLAST20
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Topological domaini564 – 570CytoplasmicSequence analysis7
Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 598ExtracellularSequence analysis7
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 638CytoplasmicSequence analysisAdd BLAST19
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Topological domaini660 – 679ExtracellularSequence analysisAdd BLAST20
Transmembranei680 – 700HelicalSequence analysisAdd BLAST21
Topological domaini701 – 981CytoplasmicSequence analysisAdd BLAST281

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163704.
PharmGKBiPA142671133.

Polymorphism and mutation databases

BioMutaiPRRT3.
DMDMi160332300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000025197828 – 981Proline-rich transmembrane protein 3Add BLAST954

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi329O-linked (GalNAc...)1 Publication1
Glycosylationi363O-linked (GalNAc...)1 Publication1
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Modified residuei777PhosphoserineBy similarity1
Modified residuei780Omega-N-methylarginineBy similarity1
Modified residuei789PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Modified residuei808PhosphoserineBy similarity1
Modified residuei815PhosphoserineCombined sources1
Modified residuei854PhosphoserineBy similarity1
Modified residuei874PhosphoserineBy similarity1
Modified residuei902PhosphoserineBy similarity1
Modified residuei903PhosphoserineBy similarity1
Modified residuei911PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ5FWE3.
PeptideAtlasiQ5FWE3.
PRIDEiQ5FWE3.

PTM databases

iPTMnetiQ5FWE3.
PhosphoSitePlusiQ5FWE3.
UniCarbKBiQ5FWE3.

Expressioni

Gene expression databases

BgeeiENSG00000163704.
CleanExiHS_PRRT3.
GenevisibleiQ5FWE3. HS.

Organism-specific databases

HPAiHPA035127.
HPA035128.

Interactioni

Protein-protein interaction databases

BioGridi130093. 1 interactor.
IntActiQ5FWE3. 1 interactor.
STRINGi9606.ENSP00000295984.

Structurei

3D structure databases

ProteinModelPortaliQ5FWE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni297 – 302O-glycosylated at one site6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 462Pro-richAdd BLAST216

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF5P. Eukaryota.
ENOG410ZJ6U. LUCA.
GeneTreeiENSGT00730000111360.
HOGENOMiHOG000115722.
HOVERGENiHBG063615.
InParanoidiQ5FWE3.
OMAiPRGWDAS.
OrthoDBiEOG091G06YH.
PhylomeDBiQ5FWE3.
TreeFamiTF333410.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5FWE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSPWGCVC GLLLLLLPLL GTGPALGRGF PRPLENSEIP MIPGAHPKGS
60 70 80 90 100
VGSEPQAFDV FPENPRADSH RNSDVRHAPA EEMPEKPVAS PLGPALYGPK
110 120 130 140 150
AAQGAQRERL PVTDDLQMAQ GPSSHGWTGP LDSQELLQQE AVAPHPVGHP
160 170 180 190 200
HLTFIPTTPR RQLRVATVPP SLQHEGQEGQ WPPRDEGLKA KTKSRVPPTS
210 220 230 240 250
PSDHQGPPHT LVSHSGTVKR PVLEGQGGFE EHLQEAAQGP HFTQQDPAAP
260 270 280 290 300
DVGSVPPVEV VYSQEPGAQP DLALARSLPP AEELPVETPK RAGAEVSWEV
310 320 330 340 350
SSPGPPPKQA DLPDAKDSPG PQPTDPPASE APDRPSKPER AAMNGADPIS
360 370 380 390 400
PQRVRGAVEA PGTPKSLIPG PSDPGPAVNR TESPMGALQP DEAEEWPGRP
410 420 430 440 450
QSHPPAPPVQ APSTSRRGLI RVTTQRALGQ PPPPEPTASS MASAPASSPP
460 470 480 490 500
ANATAPPLRW GPLRRVLSFS WELHVYGVGV LFLLPALLAL AALAAAPAGP
510 520 530 540 550
RLALVAAVLV LVASALRSAY MLTDPYGSQA RLGVRGGLVL YNLPFPLLLT
560 570 580 590 600
ALAALTLLGL GAGLPPPLQN PLLLGAVALV HGVGLLATDL LSTWSVLNLL
610 620 630 640 650
TQGLSCAWGA AVALGTLCLC RRRLLDGPRG WDASPGPRLL AVAGALGLLA
660 670 680 690 700
SGLQLAAALW LYPGPGRVGR FSWAWWGVHF WLRLLELTWA LALALAAVAA
710 720 730 740 750
ARPRPPTEHA CWAKLMRLAC PAPSGKSEVP ERPNNCYAGP SNVGAGSLDI
760 770 780 790 800
SKSLIRNPAE SGQLATPSSG AWGSAASLGR GPQGGPGLSR NGVGPAPSLS
810 820 830 840 850
ELDLRPPSPI NLSRSIDAAL FREHLVRDSV FQRCGLRGLA SPPPGGALRP
860 870 880 890 900
RRGSHPKAEL DDAGSSLLRG RCRSLSDVRV RGPVPQHVVE APDGAAAAAS
910 920 930 940 950
GSSLDSFSRG SLKISWNPWR HGLSSVDSLP LDELPSTVQL LPAPTPAPDS
960 970 980
TAARQGDGQG EVQPRGKPGE SRSASSDTIE L
Length:981
Mass (Da):102,197
Last modified:November 13, 2007 - v3
Checksum:i19632A8EA8CCEA1F
GO
Isoform 2 (identifier: Q5FWE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.

Note: No experimental confirmation available.
Show »
Length:597
Mass (Da):61,832
Checksum:iBC0A570C7E086F1C
GO
Isoform 3 (identifier: Q5FWE3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-421: DEAEEWPGRPQSHPPAPPVQAPSTSRRGLIR → GESMAGVWGEGVLCLVTENLCWGCMGAEGGE
     422-981: Missing.

Show »
Length:421
Mass (Da):44,108
Checksum:iE5657378FCBAE080
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti410Q → K in AAH40508 (PubMed:15489334).Curated1
Sequence conflicti519A → T in AAH40508 (PubMed:15489334).Curated1
Sequence conflicti819A → T in AAH40508 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027745138Q → E.Corresponds to variant rs279601dbSNPEnsembl.1
Natural variantiVAR_061695213S → P.1 PublicationCorresponds to variant rs55847610dbSNPEnsembl.1
Natural variantiVAR_061696233L → F.1 PublicationCorresponds to variant rs55847233dbSNPEnsembl.1
Natural variantiVAR_061697334R → G.1 PublicationCorresponds to variant rs59465469dbSNPEnsembl.1
Natural variantiVAR_027746860L → I.Corresponds to variant rs2279794dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0208451 – 384Missing in isoform 2. 1 PublicationAdd BLAST384
Alternative sequenceiVSP_020846391 – 421DEAEE…RGLIR → GESMAGVWGEGVLCLVTENL CWGCMGAEGGE in isoform 3. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_020847422 – 981Missing in isoform 3. 2 PublicationsAdd BLAST560

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358158 mRNA. Translation: AAQ88525.1.
BC040508 mRNA. Translation: AAH40508.1.
BC089447 mRNA. Translation: AAH89447.1.
BC111555 mRNA. Translation: AAI11556.1.
AK090993 mRNA. Translation: BAC03564.1.
CCDSiCCDS43049.1. [Q5FWE3-1]
CCDS82732.1. [Q5FWE3-3]
RefSeqiNP_001305800.1. NM_001318871.1. [Q5FWE3-3]
NP_997234.3. NM_207351.4. [Q5FWE3-1]
XP_011531930.1. XM_011533628.2. [Q5FWE3-1]
XP_011531931.1. XM_011533629.2. [Q5FWE3-1]
XP_016861745.1. XM_017006256.1. [Q5FWE3-1]
UniGeneiHs.598147.

Genome annotation databases

EnsembliENST00000295984; ENSP00000295984; ENSG00000163704. [Q5FWE3-1]
ENST00000411976; ENSP00000404512; ENSG00000163704. [Q5FWE3-3]
ENST00000412055; ENSP00000392511; ENSG00000163704. [Q5FWE3-1]
GeneIDi285368.
KEGGihsa:285368.
UCSCiuc003bul.2. human. [Q5FWE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358158 mRNA. Translation: AAQ88525.1.
BC040508 mRNA. Translation: AAH40508.1.
BC089447 mRNA. Translation: AAH89447.1.
BC111555 mRNA. Translation: AAI11556.1.
AK090993 mRNA. Translation: BAC03564.1.
CCDSiCCDS43049.1. [Q5FWE3-1]
CCDS82732.1. [Q5FWE3-3]
RefSeqiNP_001305800.1. NM_001318871.1. [Q5FWE3-3]
NP_997234.3. NM_207351.4. [Q5FWE3-1]
XP_011531930.1. XM_011533628.2. [Q5FWE3-1]
XP_011531931.1. XM_011533629.2. [Q5FWE3-1]
XP_016861745.1. XM_017006256.1. [Q5FWE3-1]
UniGeneiHs.598147.

3D structure databases

ProteinModelPortaliQ5FWE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130093. 1 interactor.
IntActiQ5FWE3. 1 interactor.
STRINGi9606.ENSP00000295984.

PTM databases

iPTMnetiQ5FWE3.
PhosphoSitePlusiQ5FWE3.
UniCarbKBiQ5FWE3.

Polymorphism and mutation databases

BioMutaiPRRT3.
DMDMi160332300.

Proteomic databases

PaxDbiQ5FWE3.
PeptideAtlasiQ5FWE3.
PRIDEiQ5FWE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295984; ENSP00000295984; ENSG00000163704. [Q5FWE3-1]
ENST00000411976; ENSP00000404512; ENSG00000163704. [Q5FWE3-3]
ENST00000412055; ENSP00000392511; ENSG00000163704. [Q5FWE3-1]
GeneIDi285368.
KEGGihsa:285368.
UCSCiuc003bul.2. human. [Q5FWE3-1]

Organism-specific databases

CTDi285368.
GeneCardsiPRRT3.
H-InvDBHIX0003040.
HGNCiHGNC:26591. PRRT3.
HPAiHPA035127.
HPA035128.
neXtProtiNX_Q5FWE3.
OpenTargetsiENSG00000163704.
PharmGKBiPA142671133.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5P. Eukaryota.
ENOG410ZJ6U. LUCA.
GeneTreeiENSGT00730000111360.
HOGENOMiHOG000115722.
HOVERGENiHBG063615.
InParanoidiQ5FWE3.
OMAiPRGWDAS.
OrthoDBiEOG091G06YH.
PhylomeDBiQ5FWE3.
TreeFamiTF333410.

Miscellaneous databases

GenomeRNAii285368.
PROiQ5FWE3.

Gene expression databases

BgeeiENSG00000163704.
CleanExiHS_PRRT3.
GenevisibleiQ5FWE3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPRRT3_HUMAN
AccessioniPrimary (citable) accession number: Q5FWE3
Secondary accession number(s): Q49AD0, Q6UXY6, Q8NBC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.