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Q5FW85

- ECM2_MOUSE

UniProt

Q5FW85 - ECM2_MOUSE

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Protein

Extracellular matrix protein 2

Gene

Ecm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes matrix assembly and cell adhesiveness.1 Publication

GO - Molecular functioni

  1. collagen binding Source: MGI
  2. collagen V binding Source: MGI
  3. heparin binding Source: MGI

GO - Biological processi

  1. extracellular matrix organization Source: MGI
  2. positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Tenonectin
Gene namesi
Name:Ecm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:3039578. Ecm2.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. interstitial matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 670651Extracellular matrix protein 2PRO_0000287728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5FW85.

PTM databases

PhosphoSiteiQ5FW85.

Expressioni

Developmental stagei

At E16.5, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level).1 Publication

Gene expression databases

BgeeiQ5FW85.
GenevestigatoriQ5FW85.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5FW85.
SMRiQ5FW85. Positions 94-152, 268-645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 15358VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini278 – 31538LRRNTAdd
BLAST
Repeati339 – 35921LRR 1Add
BLAST
Repeati365 – 38622LRR 2Add
BLAST
Repeati387 – 40721LRR 3Add
BLAST
Repeati410 – 43021LRR 4Add
BLAST
Repeati436 – 45621LRR 5Add
BLAST
Repeati457 – 47822LRR 6Add
BLAST
Repeati481 – 50121LRR 7Add
BLAST
Repeati507 – 52822LRR 8Add
BLAST
Repeati529 – 54921LRR 9Add
BLAST
Repeati553 – 57321LRR 10Add
BLAST
Repeati580 – 60122LRR 11Add
BLAST
Repeati603 – 62422LRR 12Add
BLAST
Repeati632 – 65524LRR 13Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi266 – 2683Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 26282Glu-richAdd
BLAST

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ5FW85.
KOiK08119.
OMAiAVWSPKP.
OrthoDBiEOG773XGV.
PhylomeDBiQ5FW85.
TreeFamiTF330031.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR026906. LRR_5.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FW85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLAVLFCFI LLIVLQTDCE RGTRRQRRRM HQRRLRKSSS FHLRANRQLE
60 70 80 90 100
VQQTTAAPDA RLPTANSDYS VEENIESLLS NLGVESSYSV LPGKKGYCFV
110 120 130 140 150
KGMIMYNKAV WSPEPCTTCL CSNGRVLCDE TECHPKACPY TIKPEGECCP
160 170 180 190 200
ICSDAEQESI NKLHKQVPPP QMEMDQVAIK EALQSEEDEE IAEGHKEHKK
210 220 230 240 250
ETSVPTKIHG DGERTERKLR PEKEGRSAHQ PLYHGRREEE ESKEETEREG
260 270 280 290 300
EEEEEEEEEE EEDAIRGDVF RMSSRVIPGT PRGRPRLPRS CSLSYRTISC
310 320 330 340 350
VHADFTEIPP ITAPEVTNLE LVGNSIISIP DEAFNGLPNL ERLDLSRNNI
360 370 380 390 400
TSSGIGPKAF KSLKKLMRLN MDGNNLVHIP SDLPSTLEEL KINDNNLQAI
410 420 430 440 450
DEKSLSDLNQ LVTLELEGNN LSEINVDPLA FQSLESLSYL RLGRNKFRII
460 470 480 490 500
PQGLPASTEE LYLENNQIEE ITEICFNHTR KITMIILRYN KIEESRIAPL
510 520 530 540 550
AWINQENLES IDLSYNKLYH VPSYLPKSLL HLVLIGNQID RIPGYVFGHM
560 570 580 590 600
QPGLEYLYLS FNRLSDDGVD LVSFYGAYHS LRELFLDHND FKSIPPGIQD
610 620 630 640 650
MKALHFLRLN NNKIRNIHPE QICNAEEDED SALEHLHLEN NYIRTREISS
660 670
YAFSCIRLYS SIVLKPQHIK
Length:670
Mass (Da):76,676
Last modified:March 1, 2005 - v1
Checksum:i025BE9522417F5E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK038812 mRNA. Translation: BAE20541.1.
AK040995 mRNA. Translation: BAE20587.1.
AK134746 mRNA. Translation: BAE22265.1.
BC065151 mRNA. Translation: AAH65151.1.
BC089559 mRNA. Translation: AAH89559.1.
CCDSiCCDS26502.1.
RefSeqiNP_001012324.1. NM_001012324.2.
UniGeneiMm.386931.

Genome annotation databases

EnsembliENSMUST00000051504; ENSMUSP00000060402; ENSMUSG00000043631.
GeneIDi407800.
KEGGimmu:407800.
UCSCiuc007qjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK038812 mRNA. Translation: BAE20541.1 .
AK040995 mRNA. Translation: BAE20587.1 .
AK134746 mRNA. Translation: BAE22265.1 .
BC065151 mRNA. Translation: AAH65151.1 .
BC089559 mRNA. Translation: AAH89559.1 .
CCDSi CCDS26502.1.
RefSeqi NP_001012324.1. NM_001012324.2.
UniGenei Mm.386931.

3D structure databases

ProteinModelPortali Q5FW85.
SMRi Q5FW85. Positions 94-152, 268-645.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5FW85.

Proteomic databases

PRIDEi Q5FW85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051504 ; ENSMUSP00000060402 ; ENSMUSG00000043631 .
GeneIDi 407800.
KEGGi mmu:407800.
UCSCi uc007qjl.1. mouse.

Organism-specific databases

CTDi 1842.
MGIi MGI:3039578. Ecm2.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118969.
HOGENOMi HOG000112319.
HOVERGENi HBG031529.
InParanoidi Q5FW85.
KOi K08119.
OMAi AVWSPKP.
OrthoDBi EOG773XGV.
PhylomeDBi Q5FW85.
TreeFami TF330031.

Miscellaneous databases

NextBioi 407225.
PROi Q5FW85.
SOURCEi Search...

Gene expression databases

Bgeei Q5FW85.
Genevestigatori Q5FW85.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR026906. LRR_5.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Medulla oblongata.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiECM2_MOUSE
AccessioniPrimary (citable) accession number: Q5FW85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3