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Q5FW85

- ECM2_MOUSE

UniProt

Q5FW85 - ECM2_MOUSE

Protein

Extracellular matrix protein 2

Gene

Ecm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Promotes matrix assembly and cell adhesiveness.1 Publication

    GO - Molecular functioni

    1. collagen binding Source: MGI
    2. collagen V binding Source: MGI
    3. heparin binding Source: MGI

    GO - Biological processi

    1. extracellular matrix organization Source: MGI
    2. positive regulation of cell-substrate adhesion Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular matrix protein 2
    Alternative name(s):
    Tenonectin
    Gene namesi
    Name:Ecm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:3039578. Ecm2.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix 1 Publication

    GO - Cellular componenti

    1. extracellular matrix Source: MGI
    2. interstitial matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 670651Extracellular matrix protein 2PRO_0000287728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5FW85.

    PTM databases

    PhosphoSiteiQ5FW85.

    Expressioni

    Developmental stagei

    At E16.5, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level).1 Publication

    Gene expression databases

    BgeeiQ5FW85.
    GenevestigatoriQ5FW85.

    Interactioni

    Subunit structurei

    Interacts with numerous extracellular matrix proteins.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FW85.
    SMRiQ5FW85. Positions 94-152, 288-645.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini96 – 15358VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 31538LRRNTAdd
    BLAST
    Repeati339 – 35921LRR 1Add
    BLAST
    Repeati365 – 38622LRR 2Add
    BLAST
    Repeati387 – 40721LRR 3Add
    BLAST
    Repeati410 – 43021LRR 4Add
    BLAST
    Repeati436 – 45621LRR 5Add
    BLAST
    Repeati457 – 47822LRR 6Add
    BLAST
    Repeati481 – 50121LRR 7Add
    BLAST
    Repeati507 – 52822LRR 8Add
    BLAST
    Repeati529 – 54921LRR 9Add
    BLAST
    Repeati553 – 57321LRR 10Add
    BLAST
    Repeati580 – 60122LRR 11Add
    BLAST
    Repeati603 – 62422LRR 12Add
    BLAST
    Repeati632 – 65524LRR 13Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi266 – 2683Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 26282Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 13 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00730000110250.
    HOGENOMiHOG000112319.
    HOVERGENiHBG031529.
    InParanoidiQ5FW85.
    KOiK08119.
    OMAiAVWSPKP.
    OrthoDBiEOG773XGV.
    PhylomeDBiQ5FW85.
    TreeFamiTF330031.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR026906. LRR_5.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00214. VWC. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 13 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5FW85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLAVLFCFI LLIVLQTDCE RGTRRQRRRM HQRRLRKSSS FHLRANRQLE    50
    VQQTTAAPDA RLPTANSDYS VEENIESLLS NLGVESSYSV LPGKKGYCFV 100
    KGMIMYNKAV WSPEPCTTCL CSNGRVLCDE TECHPKACPY TIKPEGECCP 150
    ICSDAEQESI NKLHKQVPPP QMEMDQVAIK EALQSEEDEE IAEGHKEHKK 200
    ETSVPTKIHG DGERTERKLR PEKEGRSAHQ PLYHGRREEE ESKEETEREG 250
    EEEEEEEEEE EEDAIRGDVF RMSSRVIPGT PRGRPRLPRS CSLSYRTISC 300
    VHADFTEIPP ITAPEVTNLE LVGNSIISIP DEAFNGLPNL ERLDLSRNNI 350
    TSSGIGPKAF KSLKKLMRLN MDGNNLVHIP SDLPSTLEEL KINDNNLQAI 400
    DEKSLSDLNQ LVTLELEGNN LSEINVDPLA FQSLESLSYL RLGRNKFRII 450
    PQGLPASTEE LYLENNQIEE ITEICFNHTR KITMIILRYN KIEESRIAPL 500
    AWINQENLES IDLSYNKLYH VPSYLPKSLL HLVLIGNQID RIPGYVFGHM 550
    QPGLEYLYLS FNRLSDDGVD LVSFYGAYHS LRELFLDHND FKSIPPGIQD 600
    MKALHFLRLN NNKIRNIHPE QICNAEEDED SALEHLHLEN NYIRTREISS 650
    YAFSCIRLYS SIVLKPQHIK 670
    Length:670
    Mass (Da):76,676
    Last modified:March 1, 2005 - v1
    Checksum:i025BE9522417F5E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK038812 mRNA. Translation: BAE20541.1.
    AK040995 mRNA. Translation: BAE20587.1.
    AK134746 mRNA. Translation: BAE22265.1.
    BC065151 mRNA. Translation: AAH65151.1.
    BC089559 mRNA. Translation: AAH89559.1.
    CCDSiCCDS26502.1.
    RefSeqiNP_001012324.1. NM_001012324.2.
    UniGeneiMm.386931.

    Genome annotation databases

    EnsembliENSMUST00000051504; ENSMUSP00000060402; ENSMUSG00000043631.
    GeneIDi407800.
    KEGGimmu:407800.
    UCSCiuc007qjl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK038812 mRNA. Translation: BAE20541.1 .
    AK040995 mRNA. Translation: BAE20587.1 .
    AK134746 mRNA. Translation: BAE22265.1 .
    BC065151 mRNA. Translation: AAH65151.1 .
    BC089559 mRNA. Translation: AAH89559.1 .
    CCDSi CCDS26502.1.
    RefSeqi NP_001012324.1. NM_001012324.2.
    UniGenei Mm.386931.

    3D structure databases

    ProteinModelPortali Q5FW85.
    SMRi Q5FW85. Positions 94-152, 288-645.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5FW85.

    Proteomic databases

    PRIDEi Q5FW85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051504 ; ENSMUSP00000060402 ; ENSMUSG00000043631 .
    GeneIDi 407800.
    KEGGi mmu:407800.
    UCSCi uc007qjl.1. mouse.

    Organism-specific databases

    CTDi 1842.
    MGIi MGI:3039578. Ecm2.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00730000110250.
    HOGENOMi HOG000112319.
    HOVERGENi HBG031529.
    InParanoidi Q5FW85.
    KOi K08119.
    OMAi AVWSPKP.
    OrthoDBi EOG773XGV.
    PhylomeDBi Q5FW85.
    TreeFami TF330031.

    Miscellaneous databases

    NextBioi 407225.
    PROi Q5FW85.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5FW85.
    Genevestigatori Q5FW85.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR026906. LRR_5.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13306. LRR_5. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00214. VWC. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 13 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hypothalamus and Medulla oblongata.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiECM2_MOUSE
    AccessioniPrimary (citable) accession number: Q5FW85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3