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Protein

Extracellular matrix protein 2

Gene

Ecm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes matrix assembly and cell adhesiveness.1 Publication

GO - Molecular functioni

  • collagen binding Source: MGI
  • collagen V binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • axonogenesis Source: GO_Central
  • extracellular matrix organization Source: MGI
  • positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Tenonectin
Gene namesi
Name:Ecm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3039578. Ecm2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • interstitial matrix Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028772820 – 670Extracellular matrix protein 2Add BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi420N-linked (GlcNAc...)Sequence analysis1
Glycosylationi477N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5FW85.
PaxDbiQ5FW85.
PRIDEiQ5FW85.

PTM databases

iPTMnetiQ5FW85.
PhosphoSitePlusiQ5FW85.

Expressioni

Developmental stagei

At E16.5, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000043631.
GenevisibleiQ5FW85. MM.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.1 Publication

GO - Molecular functioni

  • collagen binding Source: MGI
  • collagen V binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060402.

Structurei

3D structure databases

ProteinModelPortaliQ5FW85.
SMRiQ5FW85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 153VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini278 – 315LRRNTAdd BLAST38
Repeati339 – 359LRR 1Add BLAST21
Repeati365 – 386LRR 2Add BLAST22
Repeati387 – 407LRR 3Add BLAST21
Repeati410 – 430LRR 4Add BLAST21
Repeati436 – 456LRR 5Add BLAST21
Repeati457 – 478LRR 6Add BLAST22
Repeati481 – 501LRR 7Add BLAST21
Repeati507 – 528LRR 8Add BLAST22
Repeati529 – 549LRR 9Add BLAST21
Repeati553 – 573LRR 10Add BLAST21
Repeati580 – 601LRR 11Add BLAST22
Repeati603 – 624LRR 12Add BLAST22
Repeati632 – 655LRR 13Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi266 – 268Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 262Glu-richAdd BLAST82

Sequence similaritiesi

Contains 13 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ5FW85.
KOiK08119.
OMAiVWSPKPC.
OrthoDBiEOG091G03L1.
PhylomeDBiQ5FW85.
TreeFamiTF330031.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FW85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAVLFCFI LLIVLQTDCE RGTRRQRRRM HQRRLRKSSS FHLRANRQLE
60 70 80 90 100
VQQTTAAPDA RLPTANSDYS VEENIESLLS NLGVESSYSV LPGKKGYCFV
110 120 130 140 150
KGMIMYNKAV WSPEPCTTCL CSNGRVLCDE TECHPKACPY TIKPEGECCP
160 170 180 190 200
ICSDAEQESI NKLHKQVPPP QMEMDQVAIK EALQSEEDEE IAEGHKEHKK
210 220 230 240 250
ETSVPTKIHG DGERTERKLR PEKEGRSAHQ PLYHGRREEE ESKEETEREG
260 270 280 290 300
EEEEEEEEEE EEDAIRGDVF RMSSRVIPGT PRGRPRLPRS CSLSYRTISC
310 320 330 340 350
VHADFTEIPP ITAPEVTNLE LVGNSIISIP DEAFNGLPNL ERLDLSRNNI
360 370 380 390 400
TSSGIGPKAF KSLKKLMRLN MDGNNLVHIP SDLPSTLEEL KINDNNLQAI
410 420 430 440 450
DEKSLSDLNQ LVTLELEGNN LSEINVDPLA FQSLESLSYL RLGRNKFRII
460 470 480 490 500
PQGLPASTEE LYLENNQIEE ITEICFNHTR KITMIILRYN KIEESRIAPL
510 520 530 540 550
AWINQENLES IDLSYNKLYH VPSYLPKSLL HLVLIGNQID RIPGYVFGHM
560 570 580 590 600
QPGLEYLYLS FNRLSDDGVD LVSFYGAYHS LRELFLDHND FKSIPPGIQD
610 620 630 640 650
MKALHFLRLN NNKIRNIHPE QICNAEEDED SALEHLHLEN NYIRTREISS
660 670
YAFSCIRLYS SIVLKPQHIK
Length:670
Mass (Da):76,676
Last modified:March 1, 2005 - v1
Checksum:i025BE9522417F5E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038812 mRNA. Translation: BAE20541.1.
AK040995 mRNA. Translation: BAE20587.1.
AK134746 mRNA. Translation: BAE22265.1.
BC065151 mRNA. Translation: AAH65151.1.
BC089559 mRNA. Translation: AAH89559.1.
CCDSiCCDS26502.1.
RefSeqiNP_001012324.1. NM_001012324.2.
UniGeneiMm.386931.

Genome annotation databases

EnsembliENSMUST00000051504; ENSMUSP00000060402; ENSMUSG00000043631.
GeneIDi407800.
KEGGimmu:407800.
UCSCiuc007qjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038812 mRNA. Translation: BAE20541.1.
AK040995 mRNA. Translation: BAE20587.1.
AK134746 mRNA. Translation: BAE22265.1.
BC065151 mRNA. Translation: AAH65151.1.
BC089559 mRNA. Translation: AAH89559.1.
CCDSiCCDS26502.1.
RefSeqiNP_001012324.1. NM_001012324.2.
UniGeneiMm.386931.

3D structure databases

ProteinModelPortaliQ5FW85.
SMRiQ5FW85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060402.

PTM databases

iPTMnetiQ5FW85.
PhosphoSitePlusiQ5FW85.

Proteomic databases

MaxQBiQ5FW85.
PaxDbiQ5FW85.
PRIDEiQ5FW85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051504; ENSMUSP00000060402; ENSMUSG00000043631.
GeneIDi407800.
KEGGimmu:407800.
UCSCiuc007qjl.1. mouse.

Organism-specific databases

CTDi1842.
MGIiMGI:3039578. Ecm2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ5FW85.
KOiK08119.
OMAiVWSPKPC.
OrthoDBiEOG091G03L1.
PhylomeDBiQ5FW85.
TreeFamiTF330031.

Miscellaneous databases

PROiQ5FW85.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043631.
GenevisibleiQ5FW85. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECM2_MOUSE
AccessioniPrimary (citable) accession number: Q5FW85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.