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Q5FW85

- ECM2_MOUSE

UniProt

Q5FW85 - ECM2_MOUSE

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Protein
Extracellular matrix protein 2
Gene
Ecm2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes matrix assembly and cell adhesiveness.1 Publication

GO - Molecular functioni

  1. collagen V binding Source: MGI
  2. collagen binding Source: MGI
  3. heparin binding Source: MGI

GO - Biological processi

  1. extracellular matrix organization Source: MGI
  2. positive regulation of cell-substrate adhesion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular matrix protein 2
Alternative name(s):
Tenonectin
Gene namesi
Name:Ecm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:3039578. Ecm2.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 1 Publication

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. interstitial matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 670651Extracellular matrix protein 2
PRO_0000287728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi477 – 4771N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5FW85.

PTM databases

PhosphoSiteiQ5FW85.

Expressioni

Developmental stagei

At E16.5, present in periosteum of ribs. At P0, present in tendons connecting the scapula and humerus to muscles (at protein level).1 Publication

Gene expression databases

BgeeiQ5FW85.
GenevestigatoriQ5FW85.

Interactioni

Subunit structurei

Interacts with numerous extracellular matrix proteins.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5FW85.
SMRiQ5FW85. Positions 94-152, 288-645.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini96 – 15358VWFC
Add
BLAST
Domaini278 – 31538LRRNT
Add
BLAST
Repeati339 – 35921LRR 1
Add
BLAST
Repeati365 – 38622LRR 2
Add
BLAST
Repeati387 – 40721LRR 3
Add
BLAST
Repeati410 – 43021LRR 4
Add
BLAST
Repeati436 – 45621LRR 5
Add
BLAST
Repeati457 – 47822LRR 6
Add
BLAST
Repeati481 – 50121LRR 7
Add
BLAST
Repeati507 – 52822LRR 8
Add
BLAST
Repeati529 – 54921LRR 9
Add
BLAST
Repeati553 – 57321LRR 10
Add
BLAST
Repeati580 – 60122LRR 11
Add
BLAST
Repeati603 – 62422LRR 12
Add
BLAST
Repeati632 – 65524LRR 13
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi266 – 2683Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 26282Glu-rich
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.
Contains 1 VWFC domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00730000110250.
HOGENOMiHOG000112319.
HOVERGENiHBG031529.
InParanoidiQ5FW85.
KOiK08119.
OMAiAVWSPKP.
OrthoDBiEOG773XGV.
PhylomeDBiQ5FW85.
TreeFamiTF330031.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR026906. LRR_5.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FW85-1 [UniParc]FASTAAdd to Basket

« Hide

MKLAVLFCFI LLIVLQTDCE RGTRRQRRRM HQRRLRKSSS FHLRANRQLE    50
VQQTTAAPDA RLPTANSDYS VEENIESLLS NLGVESSYSV LPGKKGYCFV 100
KGMIMYNKAV WSPEPCTTCL CSNGRVLCDE TECHPKACPY TIKPEGECCP 150
ICSDAEQESI NKLHKQVPPP QMEMDQVAIK EALQSEEDEE IAEGHKEHKK 200
ETSVPTKIHG DGERTERKLR PEKEGRSAHQ PLYHGRREEE ESKEETEREG 250
EEEEEEEEEE EEDAIRGDVF RMSSRVIPGT PRGRPRLPRS CSLSYRTISC 300
VHADFTEIPP ITAPEVTNLE LVGNSIISIP DEAFNGLPNL ERLDLSRNNI 350
TSSGIGPKAF KSLKKLMRLN MDGNNLVHIP SDLPSTLEEL KINDNNLQAI 400
DEKSLSDLNQ LVTLELEGNN LSEINVDPLA FQSLESLSYL RLGRNKFRII 450
PQGLPASTEE LYLENNQIEE ITEICFNHTR KITMIILRYN KIEESRIAPL 500
AWINQENLES IDLSYNKLYH VPSYLPKSLL HLVLIGNQID RIPGYVFGHM 550
QPGLEYLYLS FNRLSDDGVD LVSFYGAYHS LRELFLDHND FKSIPPGIQD 600
MKALHFLRLN NNKIRNIHPE QICNAEEDED SALEHLHLEN NYIRTREISS 650
YAFSCIRLYS SIVLKPQHIK 670
Length:670
Mass (Da):76,676
Last modified:March 1, 2005 - v1
Checksum:i025BE9522417F5E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK038812 mRNA. Translation: BAE20541.1.
AK040995 mRNA. Translation: BAE20587.1.
AK134746 mRNA. Translation: BAE22265.1.
BC065151 mRNA. Translation: AAH65151.1.
BC089559 mRNA. Translation: AAH89559.1.
CCDSiCCDS26502.1.
RefSeqiNP_001012324.1. NM_001012324.2.
UniGeneiMm.386931.

Genome annotation databases

EnsembliENSMUST00000051504; ENSMUSP00000060402; ENSMUSG00000043631.
GeneIDi407800.
KEGGimmu:407800.
UCSCiuc007qjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK038812 mRNA. Translation: BAE20541.1 .
AK040995 mRNA. Translation: BAE20587.1 .
AK134746 mRNA. Translation: BAE22265.1 .
BC065151 mRNA. Translation: AAH65151.1 .
BC089559 mRNA. Translation: AAH89559.1 .
CCDSi CCDS26502.1.
RefSeqi NP_001012324.1. NM_001012324.2.
UniGenei Mm.386931.

3D structure databases

ProteinModelPortali Q5FW85.
SMRi Q5FW85. Positions 94-152, 288-645.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5FW85.

Proteomic databases

PRIDEi Q5FW85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051504 ; ENSMUSP00000060402 ; ENSMUSG00000043631 .
GeneIDi 407800.
KEGGi mmu:407800.
UCSCi uc007qjl.1. mouse.

Organism-specific databases

CTDi 1842.
MGIi MGI:3039578. Ecm2.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00730000110250.
HOGENOMi HOG000112319.
HOVERGENi HBG031529.
InParanoidi Q5FW85.
KOi K08119.
OMAi AVWSPKP.
OrthoDBi EOG773XGV.
PhylomeDBi Q5FW85.
TreeFami TF330031.

Miscellaneous databases

NextBioi 407225.
PROi Q5FW85.
SOURCEi Search...

Gene expression databases

Bgeei Q5FW85.
Genevestigatori Q5FW85.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR026906. LRR_5.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13306. LRR_5. 1 hit.
PF13855. LRR_8. 2 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 13 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Medulla oblongata.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiECM2_MOUSE
AccessioniPrimary (citable) accession number: Q5FW85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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