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Protein
Submitted name:

Heparin-binding EGF-like growth factor

Gene

Hbegf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Heparin-binding EGF-like growth factorImported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:HbegfImported
ORF Names:mCG_121963Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96070. Hbegf.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei162 – 184HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500934392424 – 208Sequence analysisAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 143PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiQ5FW64.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024486.
ExpressionAtlasiQ5FW64. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025363.

Structurei

3D structure databases

ProteinModelPortaliQ5FW64.
SMRiQ5FW64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 144EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IMHM. Eukaryota.
ENOG41120D3. LUCA.
HOVERGENiHBG053952.
KOiK08523.
OMAiYSYDHTT.
OrthoDBiEOG091G0RK4.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FW64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLPSVMLK LFLAAVLSAL VTGESLERLR RGLAAATSNP DPPTGSTNQL
60 70 80 90 100
LPTGGDRAQG VQDLEGTDLN LFKVAFSSKP QGLATPSKER NGKKKKKGKG
110 120 130 140 150
LGKKRDPCLR KYKDYCIHGE CRYLQEFRTP SCKCLPGYHG HRCHGLTLPV
160 170 180 190 200
ENPLYTYDHT TVLAVVAVVL SSVCLLVIVG LLMFRYHRRG GYDLESEEKV

KLGVASSH
Length:208
Mass (Da):22,808
Last modified:May 10, 2005 - v1
Checksum:i7086934E23D25F8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089607 mRNA. Translation: AAH89607.1.
AK145548 mRNA. Translation: BAE26501.1.
AK160575 mRNA. Translation: BAE35883.1.
AK164309 mRNA. Translation: BAE37729.1.
CH466557 Genomic DNA. Translation: EDK97159.1.
RefSeqiNP_034545.1. NM_010415.2.
UniGeneiMm.289681.

Genome annotation databases

GeneIDi15200.
KEGGimmu:15200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089607 mRNA. Translation: AAH89607.1.
AK145548 mRNA. Translation: BAE26501.1.
AK160575 mRNA. Translation: BAE35883.1.
AK164309 mRNA. Translation: BAE37729.1.
CH466557 Genomic DNA. Translation: EDK97159.1.
RefSeqiNP_034545.1. NM_010415.2.
UniGeneiMm.289681.

3D structure databases

ProteinModelPortaliQ5FW64.
SMRiQ5FW64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025363.

Proteomic databases

MaxQBiQ5FW64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15200.
KEGGimmu:15200.

Organism-specific databases

CTDi1839.
MGIiMGI:96070. Hbegf.

Phylogenomic databases

eggNOGiENOG410IMHM. Eukaryota.
ENOG41120D3. LUCA.
HOVERGENiHBG053952.
KOiK08523.
OMAiYSYDHTT.
OrthoDBiEOG091G0RK4.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024486.
ExpressionAtlasiQ5FW64. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5FW64_MOUSE
AccessioniPrimary (citable) accession number: Q5FW64
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 12, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.