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Q5FW48

- ASPD_XENTR

UniProt

Q5FW48 - ASPD_XENTR

Protein

Putative L-aspartate dehydrogenase

Gene

aspdh

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.By similarity

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei127 – 1271NAD; via amide nitrogenBy similarity
    Binding sitei194 – 1941NADBy similarity

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative L-aspartate dehydrogenase (EC:1.4.1.21)
    Alternative name(s):
    Aspartate dehydrogenase domain-containing protein
    Gene namesi
    Name:aspdh
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-6454901. aspdh.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Putative L-aspartate dehydrogenasePRO_0000144904Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FW48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.Curated

    Phylogenomic databases

    HOVERGENiHBG062283.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FW48-1 [UniParc]FASTAAdd to Basket

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    MSEERRMRIG VVGYGHIGKY LVDKIVREGA NHSMELAFVW NRRREKLSGA    50
    VDPRLQLQDL SDCQKWAADL IVEVAHPCIT REYGEKFLSV AHFLVGSPTA 100
    LADTVTEAKL RERARLSGNT LYVPCGALWG AEDIFKMAER GTLKALRITM 150
    TKHPNSFKLE GDLVQKNQEA MSNRTVLYEG PVRGLCPLAP NNVNTMAAAC 200
    MAAHTLGFDG VVGVLVSDPS VPDWHFVDIE VTGGTIEKTG QVFSVKTSRR 250
    NPAAPCSVTG SATFASFWSS LLACKGHGGR VYIC 284
    Length:284
    Mass (Da):31,054
    Last modified:March 1, 2005 - v1
    Checksum:i790C024CBE196BCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089631 mRNA. Translation: AAH89631.1.
    RefSeqiNP_001015700.1. NM_001015700.1.
    UniGeneiStr.33092.

    Genome annotation databases

    GeneIDi548417.
    KEGGixtr:548417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089631 mRNA. Translation: AAH89631.1 .
    RefSeqi NP_001015700.1. NM_001015700.1.
    UniGenei Str.33092.

    3D structure databases

    ProteinModelPortali Q5FW48.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 548417.
    KEGGi xtr:548417.

    Organism-specific databases

    CTDi 554235.
    Xenbasei XB-GENE-6454901. aspdh.

    Phylogenomic databases

    HOVERGENi HBG062283.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiASPD_XENTR
    AccessioniPrimary (citable) accession number: Q5FW48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3