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Q5FW48 (ASPD_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative L-aspartate dehydrogenase

EC=1.4.1.21
Alternative name(s):
Aspartate dehydrogenase domain-containing protein
Gene names
Name:aspdh
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

NADP catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

aspartate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Putative L-aspartate dehydrogenase
PRO_0000144904

Sites

Binding site1271NAD; via amide nitrogen By similarity
Binding site1941NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FW48 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 790C024CBE196BCC

FASTA28431,054
        10         20         30         40         50         60 
MSEERRMRIG VVGYGHIGKY LVDKIVREGA NHSMELAFVW NRRREKLSGA VDPRLQLQDL 

        70         80         90        100        110        120 
SDCQKWAADL IVEVAHPCIT REYGEKFLSV AHFLVGSPTA LADTVTEAKL RERARLSGNT 

       130        140        150        160        170        180 
LYVPCGALWG AEDIFKMAER GTLKALRITM TKHPNSFKLE GDLVQKNQEA MSNRTVLYEG 

       190        200        210        220        230        240 
PVRGLCPLAP NNVNTMAAAC MAAHTLGFDG VVGVLVSDPS VPDWHFVDIE VTGGTIEKTG 

       250        260        270        280 
QVFSVKTSRR NPAAPCSVTG SATFASFWSS LLACKGHGGR VYIC 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089631 mRNA. Translation: AAH89631.1.
RefSeqNP_001015700.1. NM_001015700.1.
UniGeneStr.33092.

3D structure databases

ProteinModelPortalQ5FW48.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID548417.
KEGGxtr:548417.

Organism-specific databases

CTD554235.
XenbaseXB-GENE-6454901. aspdh.

Phylogenomic databases

HOVERGENHBG062283.

Enzyme and pathway databases

UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD_XENTR
AccessionPrimary (citable) accession number: Q5FW48
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2005
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways