Reviewed, UniProtKB/Swiss-Prot Q5FW48 (ASPD_XENTR)

Names and origin

Protein names

Recommended name:
    Putative L-aspartate dehydrogenase
    EC=1.4.1.21
Alternative name(s):
    Aspartate dehydrogenase domain-containing protein

Gene names

Name:

aspdh

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.
Catalytic activity	L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.
Miscellaneous	The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.
Sequence similarities	Belongs to the L-aspartate dehydrogenase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	NAD NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro NADP catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro aspartate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Putative L-aspartate dehydrogenase		PRO_0000144904
Sites
	Binding site	127	1	NAD; via amide nitrogen By similarity
	Binding site	194	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FW48-1 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 790C024CBE196BCC	FASTA	284	31,054
	10 20 30 40 50 60 MSEERRMRIG VVGYGHIGKY LVDKIVREGA NHSMELAFVW NRRREKLSGA VDPRLQLQDL 70 80 90 100 110 120 SDCQKWAADL IVEVAHPCIT REYGEKFLSV AHFLVGSPTA LADTVTEAKL RERARLSGNT 130 140 150 160 170 180 LYVPCGALWG AEDIFKMAER GTLKALRITM TKHPNSFKLE GDLVQKNQEA MSNRTVLYEG 190 200 210 220 230 240 PVRGLCPLAP NNVNTMAAAC MAAHTLGFDG VVGVLVSDPS VPDWHFVDIE VTGGTIEKTG 250 260 270 280 QVFSVKTSRR NPAAPCSVTG SATFASFWSS LLACKGHGGR VYIC

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089631 mRNA. Translation: AAH89631.1.
RefSeq	NP_001015700.1.
UniGene	Str.33092
3D structure databases
SMR	Q5FW48. Positions 7-254.
ModBase	Search...
Genome annotation databases
GeneID	548417.
KEGG	xtr:548417.
Organism-specific databases
CTD	548417.
Phylogenomic databases
HOVERGEN	Q5FW48.
Enzyme and pathway databases
BRENDA	1.4.1.21. 279072.
Family and domain databases
InterPro	IPR005106. Asp/hSer_DH_NAD-bd. IPR002811. Asp_DH. IPR011182. Asp_DH_NAD_syn. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01958. DUF108. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ASPD_XENTR

Accession

Primary (citable) accession number: Q5FW48

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	March 1, 2005
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project