Pyruvate dehydrogenase kinase, isozyme 1 - Rattus norvegicus (Rat)

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Unreviewed, UniProtKB/TrEMBL Q5FVT5 (Q5FVT5_RAT)

Last modified February 9, 2010. Version 49. History...

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Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Pyruvate dehydrogenase kinase, isozyme 1 EMBL AAH89783.1

Gene names

Name:

Pdk1 RGD 69427

Organism

Rattus norvegicus (Rat) EMBL AAH89783.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Ligand	Pyruvate EMBL AAH89783.1
Molecular function	Kinase EMBL AAH89783.1 Transferase
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Inferred from mutant phenotype. Source: RGD peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrion Traceable author statement. Source: RGD pyruvate dehydrogenase complex Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from direct assay. Source: RGD protein complex binding Inferred from direct assay. Source: RGD protein heterodimerization activity Inferred from direct assay. Source: RGD protein homodimerization activity Inferred from direct assay. Source: RGD pyruvate dehydrogenase (acetyl-transferring) kinase activity Inferred from direct assay. Source: RGD two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q5FVT5-1 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 79592FF95CF4FFFC
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434

49,095

        10         20         30         40         50         60 
MRLARLLRGG TSVRPLCAVP CASRSLASDS ASGSGPASES GVPGQVDFYA RFSPSPLSMK 

        70         80         90        100        110        120 
QFLDFGSVNA CEKTSFMFLR QELPVRLANI MKEISLLPDN LLRTPSVQLV QSWYIQSLQE 

       130        140        150        160        170        180 
LLDFKDKSAE DAKTIYEFTD TVIRIRNRHN DVIPTMAQGV TEYKESFGVD PVTSQNVQYF 

       190        200        210        220        230        240 
LDRFYMSRIS IRMLLNQHSL LFGGKGSPSH RKHIGSINPN CDVVEVIKDG YENARRLCDL 

       250        260        270        280        290        300 
YYINSPELEL EELNAKSPGQ PIQVVYVPSH LYHMVFELFK NAMRATMEHH ADKGVYPPIQ 

       310        320        330        340        350        360 
VHVTLGEEDL TVKMSDRGGG VPLRKIDRLF NYMYSTAPRP RVETSRAVPL AGFGYGLPIS 

       370        380        390        400        410        420 
RLYAQYFQGD LKLYSLEGYG TDAVIYIKAL STESIERLPV YNKAAWKHYR TNHEADDWCV 

       430 
PSREPKDMTT FRSS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver EMBL AAH89783.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089783 mRNA. Translation: AAH89783.1.
IPI	IPI00554328.
RefSeq	NP_446278.2.
UniGene	Rn.11185
3D structure databases
SMR	Q5FVT5. Positions 41-421.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5FVT5.
Genome annotation databases
Ensembl	ENSRNOT00000002072; ENSRNOP00000002072; ENSRNOG00000001517; Rattus norvegicus. [Genome view]
GeneID	116551.
KEGG	rno:116551.
Organism-specific databases
CTD	116551.
Phylogenomic databases
eggNOG	maNOG08588.
HOVERGEN	Q5FVT5.
InParanoid	Q5FVT5.
PhylomeDB	Q5FVT5.
Gene expression databases
ArrayExpress	Q5FVT5.
Genevestigator	Q5FVT5.
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR018955. BCDHK/PDK_mit. IPR005467. Sig_transdc_His_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF10436. BCDHK_Adom3. 1 hit. PF02518. HATPase_c. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
PROSITE	PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	619183.

Entry information

Entry name

Q5FVT5_RAT

Accession

Primary (citable) accession number: Q5FVT5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · Ontologies · Sequences · References · Cross-references · Entry information