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Protein

Erythropoietin receptor

Gene

Epor

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for erythropoietin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116Required for ligand bindingUniRule annotation1
Sitei425Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei455Required for STAT1/STAT3 activationUniRule annotation1
Sitei484Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin receptorUniRule annotation
Short name:
EPO-RUniRule annotation
Gene namesi
Name:EporImported
ORF Names:rCG_31781Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2560. Epor.

Subcellular locationi

  • Membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei250 – 271HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500878128026 – 507Erythropoietin receptorSequence analysisAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 62UniRule annotation
Disulfide bondi90 ↔ 106UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000012619.

Interactioni

Subunit structurei

Forms homodimers on EPO stimulation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei367Interaction with APS and STAT5, and activationUniRule annotation1
Sitei453Interaction with PTPN6UniRule annotation1

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017369.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 246Fibronectin type-IIIInterPro annotationAdd BLAST101

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH. Eukaryota.
ENOG4111PGS. LUCA.
GeneTreeiENSGT00840000129885.
HOVERGENiHBG005595.
KOiK05079.
OMAiFMVRARM.
OrthoDBiEOG091G0AK8.
TreeFamiTF336573.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR009167. Erythropoietin_rcpt.
IPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]
PANTHERiPTHR23037:SF28. PTHR23037:SF28. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
PIRSFiPIRSF001959. EPO_receptor. 1 hit.
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQLRVARWP RVSPLCLLLA GAAWASSPSL PDPKFESKAA LLASRGSEEL
60 70 80 90 100
LCFTQRLEDL VCFWEEAANS GMGFNYSFSY QLEGESRKSC RLHQAPTVRG
110 120 130 140 150
SMRFWCSLPT ADTSSFVPLE LQVTEASGSP RYHRIIHINE VVLLDAPAGL
160 170 180 190 200
LARRAEEGSH VVLRWLPPPG APMTTHIRYE VDVSAGNRAG GTQRVEVLEG
210 220 230 240 250
RTECVLSNLR GGTRYTFAVR ARMAEPSFSG FWSAWSEPAS LLTASDLDPL
260 270 280 290 300
ILTLSLILVL ISLLLTVLAL LSHRRALRQK IWPGIPSPEN EFEGLFTTHK
310 320 330 340 350
GNFQLWLLQR DGCLWWSPSS PFPEDPPAHL EVLSERHWGV TQAGDAGAED
360 370 380 390 400
KGPLLEPVGS ERAQDTYLVL DEWLLPRCPC SENLSGPGDS VDPATMDEGS
410 420 430 440 450
ETSSCPSDLA SKPRPEGTSP SSFEYTILDP SSKLLCPRAL PPELPPTPPH
460 470 480 490 500
LKYLYLVVSD SGISTDYSSG GSQGVHGDSS DGPYSHPYEN SLVPDTEPLR

PSYVACS
Length:507
Mass (Da):55,481
Last modified:March 1, 2005 - v1
Checksum:iBDAF78B485F8E0C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128932 Genomic DNA. No translation available.
BC089810 mRNA. Translation: AAH89810.1.
CH473993 Genomic DNA. Translation: EDL78249.1.
RefSeqiNP_058698.2. NM_017002.2.
UniGeneiRn.22394.

Genome annotation databases

EnsembliENSRNOT00000017369; ENSRNOP00000017369; ENSRNOG00000012619.
GeneIDi24336.
KEGGirno:24336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128932 Genomic DNA. No translation available.
BC089810 mRNA. Translation: AAH89810.1.
CH473993 Genomic DNA. Translation: EDL78249.1.
RefSeqiNP_058698.2. NM_017002.2.
UniGeneiRn.22394.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017369; ENSRNOP00000017369; ENSRNOG00000012619.
GeneIDi24336.
KEGGirno:24336.

Organism-specific databases

CTDi2057.
RGDi2560. Epor.

Phylogenomic databases

eggNOGiENOG410IFGH. Eukaryota.
ENOG4111PGS. LUCA.
GeneTreeiENSGT00840000129885.
HOVERGENiHBG005595.
KOiK05079.
OMAiFMVRARM.
OrthoDBiEOG091G0AK8.
TreeFamiTF336573.

Gene expression databases

BgeeiENSRNOG00000012619.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR009167. Erythropoietin_rcpt.
IPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
[Graphical view]
PANTHERiPTHR23037:SF28. PTHR23037:SF28. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
PF00041. fn3. 1 hit.
[Graphical view]
PIRSFiPIRSF001959. EPO_receptor. 1 hit.
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5FVS4_RAT
AccessioniPrimary (citable) accession number: Q5FVS4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.