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Protein

Cleavage and polyadenylation specificity factor subunit 4

Gene

Cpsf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 142C3H1-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri143 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri217 – 234CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-109688 Cleavage of Growing Transcript in the Termination Region
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-72187 mRNA 3'-end processing
R-RNO-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 4
Alternative name(s):
Cleavage and polyadenylation specificity factor 30 kDa subunit
Short name:
CPSF 30 kDa subunit
Gene namesi
Name:Cpsf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620440 Cpsf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002660211 – 243Cleavage and polyadenylation specificity factor subunit 4Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVR7

PTM databases

PhosphoSitePlusiQ5FVR7

Expressioni

Gene expression databases

BgeeiENSRNOG00000000985
ExpressionAtlasiQ5FVR7 baseline
GenevisibleiQ5FVR7 RN

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046991

Structurei

3D structure databases

ProteinModelPortaliQ5FVR7
SMRiQ5FVR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CPSF4/YTH1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri35 – 61C3H1-type 1PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri62 – 89C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri90 – 117C3H1-type 3PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri118 – 142C3H1-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri143 – 169C3H1-type 5PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri217 – 234CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040 Eukaryota
COG5084 LUCA
GeneTreeiENSGT00390000009627
HOGENOMiHOG000212457
HOVERGENiHBG051108
InParanoidiQ5FVR7
KOiK14404
OMAiANKCTKG
OrthoDBiEOG091G0JUF
PhylomeDBiQ5FVR7
TreeFamiTF314871

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SM00356 ZnF_C3H1, 5 hits
SUPFAMiSSF57756 SSF57756, 1 hit
SSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 5 hits
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEIIASVDH IKFDLEIAVE QQLGAQPLPF PGMDKSGAAV CEFFLKAACG
60 70 80 90 100
KGGMCPFRHI SGEKTVVCKH WLRGLCKKGD QCEFLHEYDM TKMPECYFYS
110 120 130 140 150
KFGECSNKEC PFLHIDPESK IKDCPWYDRG FCKHGPLCRH RHTRRVICVN
160 170 180 190 200
YLVGFCPEGP SCKFMHPRFE LPMGTTEQPP LPQQTQPPTK RAPQVIGVMQ
210 220 230 240
SQNSSAGNRG PRPLEQVTCY KCGEKGHYAN RCTKGHLAFL SGQ
Length:243
Mass (Da):27,419
Last modified:March 1, 2005 - v1
Checksum:i3520EB40BD525C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089824 mRNA Translation: AAH89824.1
RefSeqiNP_001012351.1, NM_001012351.2
UniGeneiRn.104788

Genome annotation databases

EnsembliENSRNOT00000042474; ENSRNOP00000046991; ENSRNOG00000000985
GeneIDi304277
KEGGirno:304277

Similar proteinsi

Entry informationi

Entry nameiCPSF4_RAT
AccessioniPrimary (citable) accession number: Q5FVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health