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Q5FVR2

- TYPH_RAT

UniProt

Q5FVR2 - TYPH_RAT

Protein

Thymidine phosphorylase

Gene

Tymp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.By similarity

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_209708. Pyrimidine catabolism.
    REACT_221948. Pyrimidine salvage reactions.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylase (EC:2.4.2.4)
    Short name:
    TP
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:Tymp
    Synonyms:Ecgf1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1305756. Tymp.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Thymidine phosphorylasePRO_0000319099Add
    BLAST

    Proteomic databases

    PaxDbiQ5FVR2.
    PRIDEiQ5FVR2.

    PTM databases

    PhosphoSiteiQ5FVR2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5FVR2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000039935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FVR2.
    SMRiQ5FVR2. Positions 27-471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0213.
    GeneTreeiENSGT00390000009250.
    HOGENOMiHOG000047313.
    HOVERGENiHBG000082.
    InParanoidiQ5FVR2.
    KOiK00758.
    OMAiNVGHTLE.
    OrthoDBiEOG744T97.
    PhylomeDBiQ5FVR2.
    TreeFamiTF332198.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FVR2-1 [UniParc]FASTAAdd to Basket

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    MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF    50
    VHALMDGRAQ DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA 100
    WHQQLVDKHS TGGVGDKVSL VLAPALAACG CKVPMISGRS LGHTGGTLDK 150
    LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ SEKLVPADGI LYAARDVTAT 200
    VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK ARELAKMLVR 250
    VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI 300
    RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA 350
    RALCSGSPTQ RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG 400
    RSRAGQPIRP GVGAELLVDV GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG 450
    ALVLSDRAPF KAPSPFAELV LPPTTP 476
    Length:476
    Mass (Da):49,901
    Last modified:March 1, 2005 - v1
    Checksum:i1BB6068E2D94D24A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089830 mRNA. Translation: AAH89830.1.
    RefSeqiNP_001012122.1. NM_001012122.1.
    UniGeneiRn.219088.

    Genome annotation databases

    EnsembliENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
    GeneIDi315219.
    KEGGirno:315219.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089830 mRNA. Translation: AAH89830.1 .
    RefSeqi NP_001012122.1. NM_001012122.1.
    UniGenei Rn.219088.

    3D structure databases

    ProteinModelPortali Q5FVR2.
    SMRi Q5FVR2. Positions 27-471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000039935.

    Chemistry

    ChEMBLi CHEMBL1075244.

    PTM databases

    PhosphoSitei Q5FVR2.

    Proteomic databases

    PaxDbi Q5FVR2.
    PRIDEi Q5FVR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000040541 ; ENSRNOP00000039935 ; ENSRNOG00000032394 .
    GeneIDi 315219.
    KEGGi rno:315219.

    Organism-specific databases

    CTDi 1890.
    RGDi 1305756. Tymp.

    Phylogenomic databases

    eggNOGi COG0213.
    GeneTreei ENSGT00390000009250.
    HOGENOMi HOG000047313.
    HOVERGENi HBG000082.
    InParanoidi Q5FVR2.
    KOi K00758.
    OMAi NVGHTLE.
    OrthoDBi EOG744T97.
    PhylomeDBi Q5FVR2.
    TreeFami TF332198.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    Reactomei REACT_209708. Pyrimidine catabolism.
    REACT_221948. Pyrimidine salvage reactions.

    Miscellaneous databases

    NextBioi 668926.
    PROi Q5FVR2.

    Gene expression databases

    Genevestigatori Q5FVR2.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiTYPH_RAT
    AccessioniPrimary (citable) accession number: Q5FVR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3