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Protein

Thymidine phosphorylase

Gene

Tymp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_336189. Pyrimidine catabolism.
REACT_353338. Pyrimidine salvage reactions.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Short name:
TP
Alternative name(s):
TdRPase
Gene namesi
Name:Tymp
Synonyms:Ecgf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305756. Tymp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Thymidine phosphorylasePRO_0000319099Add
BLAST

Proteomic databases

PaxDbiQ5FVR2.
PRIDEiQ5FVR2.

PTM databases

PhosphoSiteiQ5FVR2.

Expressioni

Gene expression databases

GenevestigatoriQ5FVR2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039935.

Structurei

3D structure databases

ProteinModelPortaliQ5FVR2.
SMRiQ5FVR2. Positions 27-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
GeneTreeiENSGT00390000009250.
HOGENOMiHOG000047313.
HOVERGENiHBG000082.
InParanoidiQ5FVR2.
KOiK00758.
OMAiESVPGFH.
OrthoDBiEOG744T97.
PhylomeDBiQ5FVR2.
TreeFamiTF332198.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF
60 70 80 90 100
VHALMDGRAQ DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA
110 120 130 140 150
WHQQLVDKHS TGGVGDKVSL VLAPALAACG CKVPMISGRS LGHTGGTLDK
160 170 180 190 200
LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ SEKLVPADGI LYAARDVTAT
210 220 230 240 250
VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK ARELAKMLVR
260 270 280 290 300
VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI
310 320 330 340 350
RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA
360 370 380 390 400
RALCSGSPTQ RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG
410 420 430 440 450
RSRAGQPIRP GVGAELLVDV GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG
460 470
ALVLSDRAPF KAPSPFAELV LPPTTP
Length:476
Mass (Da):49,901
Last modified:February 28, 2005 - v1
Checksum:i1BB6068E2D94D24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089830 mRNA. Translation: AAH89830.1.
RefSeqiNP_001012122.1. NM_001012122.1.
UniGeneiRn.219088.

Genome annotation databases

EnsembliENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
GeneIDi315219.
KEGGirno:315219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089830 mRNA. Translation: AAH89830.1.
RefSeqiNP_001012122.1. NM_001012122.1.
UniGeneiRn.219088.

3D structure databases

ProteinModelPortaliQ5FVR2.
SMRiQ5FVR2. Positions 27-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039935.

Chemistry

BindingDBiQ5FVR2.
ChEMBLiCHEMBL1075244.

PTM databases

PhosphoSiteiQ5FVR2.

Proteomic databases

PaxDbiQ5FVR2.
PRIDEiQ5FVR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
GeneIDi315219.
KEGGirno:315219.

Organism-specific databases

CTDi1890.
RGDi1305756. Tymp.

Phylogenomic databases

eggNOGiCOG0213.
GeneTreeiENSGT00390000009250.
HOGENOMiHOG000047313.
HOVERGENiHBG000082.
InParanoidiQ5FVR2.
KOiK00758.
OMAiESVPGFH.
OrthoDBiEOG744T97.
PhylomeDBiQ5FVR2.
TreeFamiTF332198.

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.
ReactomeiREACT_336189. Pyrimidine catabolism.
REACT_353338. Pyrimidine salvage reactions.

Miscellaneous databases

NextBioi668926.
PROiQ5FVR2.

Gene expression databases

GenevestigatoriQ5FVR2.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTYPH_RAT
AccessioniPrimary (citable) accession number: Q5FVR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: February 28, 2005
Last modified: March 31, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.