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Q5FVR2

- TYPH_RAT

UniProt

Q5FVR2 - TYPH_RAT

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Protein

Thymidine phosphorylase

Gene
Tymp, Ecgf1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_209708. Pyrimidine catabolism.
REACT_221948. Pyrimidine salvage reactions.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Short name:
TP
Alternative name(s):
TdRPase
Gene namesi
Name:Tymp
Synonyms:Ecgf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi1305756. Tymp.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Thymidine phosphorylasePRO_0000319099Add
BLAST

Proteomic databases

PaxDbiQ5FVR2.
PRIDEiQ5FVR2.

PTM databases

PhosphoSiteiQ5FVR2.

Expressioni

Gene expression databases

GenevestigatoriQ5FVR2.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039935.

Structurei

3D structure databases

ProteinModelPortaliQ5FVR2.
SMRiQ5FVR2. Positions 27-471.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
GeneTreeiENSGT00390000009250.
HOGENOMiHOG000047313.
HOVERGENiHBG000082.
InParanoidiQ5FVR2.
KOiK00758.
OMAiNVGHTLE.
OrthoDBiEOG744T97.
PhylomeDBiQ5FVR2.
TreeFamiTF332198.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVR2-1 [UniParc]FASTAAdd to Basket

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MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF    50
VHALMDGRAQ DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA 100
WHQQLVDKHS TGGVGDKVSL VLAPALAACG CKVPMISGRS LGHTGGTLDK 150
LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ SEKLVPADGI LYAARDVTAT 200
VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK ARELAKMLVR 250
VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI 300
RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA 350
RALCSGSPTQ RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG 400
RSRAGQPIRP GVGAELLVDV GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG 450
ALVLSDRAPF KAPSPFAELV LPPTTP 476
Length:476
Mass (Da):49,901
Last modified:March 1, 2005 - v1
Checksum:i1BB6068E2D94D24A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089830 mRNA. Translation: AAH89830.1.
RefSeqiNP_001012122.1. NM_001012122.1.
UniGeneiRn.219088.

Genome annotation databases

EnsembliENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
GeneIDi315219.
KEGGirno:315219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089830 mRNA. Translation: AAH89830.1 .
RefSeqi NP_001012122.1. NM_001012122.1.
UniGenei Rn.219088.

3D structure databases

ProteinModelPortali Q5FVR2.
SMRi Q5FVR2. Positions 27-471.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000039935.

Chemistry

ChEMBLi CHEMBL1075244.

PTM databases

PhosphoSitei Q5FVR2.

Proteomic databases

PaxDbi Q5FVR2.
PRIDEi Q5FVR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000040541 ; ENSRNOP00000039935 ; ENSRNOG00000032394 .
GeneIDi 315219.
KEGGi rno:315219.

Organism-specific databases

CTDi 1890.
RGDi 1305756. Tymp.

Phylogenomic databases

eggNOGi COG0213.
GeneTreei ENSGT00390000009250.
HOGENOMi HOG000047313.
HOVERGENi HBG000082.
InParanoidi Q5FVR2.
KOi K00758.
OMAi NVGHTLE.
OrthoDBi EOG744T97.
PhylomeDBi Q5FVR2.
TreeFami TF332198.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .
Reactomei REACT_209708. Pyrimidine catabolism.
REACT_221948. Pyrimidine salvage reactions.

Miscellaneous databases

NextBioi 668926.
PROi Q5FVR2.

Gene expression databases

Genevestigatori Q5FVR2.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTYPH_RAT
AccessioniPrimary (citable) accession number: Q5FVR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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