Q5FVR2 (TYPH_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine phosphorylase
Short name=TP
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Name:	Tymp
Synonyms:	Ecgf1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Pathway	Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro pyrimidine-nucleoside phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Thymidine phosphorylase		PRO_0000319099

Sequences

	Sequence		Length	Mass (Da)
	Q5FVR2 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 1BB6068E2D94D24A	FASTA	476	49,901
	10 20 30 40 50 60 MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF VHALMDGRAQ 70 80 90 100 110 120 DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA WHQQLVDKHS TGGVGDKVSL 130 140 150 160 170 180 VLAPALAACG CKVPMISGRS LGHTGGTLDK LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ 190 200 210 220 230 240 SEKLVPADGI LYAARDVTAT VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK 250 260 270 280 290 300 ARELAKMLVR VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI 310 320 330 340 350 360 RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA RALCSGSPTQ 370 380 390 400 410 420 RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG RSRAGQPIRP GVGAELLVDV 430 440 450 460 470 GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG ALVLSDRAPF KAPSPFAELV LPPTTP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089830 mRNA. Translation: AAH89830.1.
IPI	IPI00361478.
RefSeq	NP_001012122.1. NM_001012122.1.
UniGene	Rn.219088.
3D structure databases
ProteinModelPortal	Q5FVR2.
SMR	Q5FVR2. Positions 27-471.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000039935.
PTM databases
PhosphoSite	Q5FVR2.
Proteomic databases
PaxDb	Q5FVR2.
PRIDE	Q5FVR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
GeneID	315219.
KEGG	rno:315219.
Organism-specific databases
CTD	1890.
RGD	1305756. Tymp.
Phylogenomic databases
eggNOG	COG0213.
GeneTree	ENSGT00390000009250.
HOGENOM	HOG000047313.
HOVERGEN	HBG000082.
InParanoid	Q5FVR2.
KO	K00758.
OMA	MDNPLGR.
OrthoDB	EOG4DJJWP.
Enzyme and pathway databases
UniPathway	UPA00578; UER00638.
Gene expression databases
ArrayExpress	Q5FVR2.
Genevestigator	Q5FVR2.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075244.
NextBio	668926.

Entry information

Entry name

TYPH_RAT

Accession

Primary (citable) accession number: Q5FVR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2005
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program