Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidine phosphorylase

Gene

Tymp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).By similarity

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi: dTMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Thymidine phosphorylase (Tymp)
  2. no protein annotated in this organism
This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-73614 Pyrimidine salvage
R-RNO-73621 Pyrimidine catabolism
UniPathwayiUPA00578; UER00638

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Short name:
TP
Alternative name(s):
TdRPase
Gene namesi
Name:Tymp
Synonyms:Ecgf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305756 Tymp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003190991 – 476Thymidine phosphorylaseAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphothreonineCombined sources1
Modified residuei475PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVR2
PRIDEiQ5FVR2

PTM databases

iPTMnetiQ5FVR2
PhosphoSitePlusiQ5FVR2

Expressioni

Gene expression databases

BgeeiENSRNOG00000032394

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039935

Chemistry databases

BindingDBiQ5FVR2

Structurei

3D structure databases

ProteinModelPortaliQ5FVR2
SMRiQ5FVR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IIV8 Eukaryota
COG0213 LUCA
GeneTreeiENSGT00390000009250
HOGENOMiHOG000047313
HOVERGENiHBG000082
InParanoidiQ5FVR2
KOiK00758
OMAiQMVASIM
OrthoDBiEOG091G08UG
PhylomeDBiQ5FVR2
TreeFamiTF332198

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR018090 Pyrmidine_PPas_bac/euk
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02644 Y_phosphoryl, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF
60 70 80 90 100
VHALMDGRAQ DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA
110 120 130 140 150
WHQQLVDKHS TGGVGDKVSL VLAPALAACG CKVPMISGRS LGHTGGTLDK
160 170 180 190 200
LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ SEKLVPADGI LYAARDVTAT
210 220 230 240 250
VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK ARELAKMLVR
260 270 280 290 300
VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI
310 320 330 340 350
RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA
360 370 380 390 400
RALCSGSPTQ RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG
410 420 430 440 450
RSRAGQPIRP GVGAELLVDV GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG
460 470
ALVLSDRAPF KAPSPFAELV LPPTTP
Length:476
Mass (Da):49,901
Last modified:March 1, 2005 - v1
Checksum:i1BB6068E2D94D24A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089830 mRNA Translation: AAH89830.1
RefSeqiNP_001012122.1, NM_001012122.1
UniGeneiRn.219088

Genome annotation databases

EnsembliENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394
GeneIDi315219
KEGGirno:315219

Similar proteinsi

Entry informationi

Entry nameiTYPH_RAT
AccessioniPrimary (citable) accession number: Q5FVR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health