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Q5FVR2 (TYPH_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

Short name=TP
EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:Tymp
Synonyms:Ecgf1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis By similarity.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Thymidine phosphorylase
PRO_0000319099

Sequences

Sequence LengthMass (Da)Tools
Q5FVR2 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 1BB6068E2D94D24A

FASTA47649,901
        10         20         30         40         50         60 
MAAPGTPPPL APETAGADSG GGSGEHRQLP ELIRLKRNGG HLSEADIRNF VHALMDGRAQ 

        70         80         90        100        110        120 
DTQIGAMLMA IRLQGMDLEE TSVLTQALAE SGQQLEWPKA WHQQLVDKHS TGGVGDKVSL 

       130        140        150        160        170        180 
VLAPALAACG CKVPMISGRS LGHTGGTLDK LESIPGFSVT QSPEQMLQIL EEVGCCIVGQ 

       190        200        210        220        230        240 
SEKLVPADGI LYAARDVTAT VDSVPLITAS ILSKKAVEGL STLVVDVKFG GAAVFPDQEK 

       250        260        270        280        290        300 
ARELAKMLVR VGMGLGLQVA AALTAMDNPL GRNVGHTLEV EEALLCLDGA GPPDLRDLVI 

       310        320        330        340        350        360 
RLGGAILWLS GQAETQDQGA ARVAAALDDG SALHRFQLML SAQGVDPGLA RALCSGSPTQ 

       370        380        390        400        410        420 
RRQLLPHARK QEELLSPADG IVECVRALPL ACVLHELGAG RSRAGQPIRP GVGAELLVDV 

       430        440        450        460        470 
GQWLSRGTPW LRVHLDGPAL SSQQRRTLLG ALVLSDRAPF KAPSPFAELV LPPTTP 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089830 mRNA. Translation: AAH89830.1.
RefSeqNP_001012122.1. NM_001012122.1.
UniGeneRn.219088.

3D structure databases

ProteinModelPortalQ5FVR2.
SMRQ5FVR2. Positions 27-471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000039935.

Chemistry

ChEMBLCHEMBL1075244.

PTM databases

PhosphoSiteQ5FVR2.

Proteomic databases

PaxDbQ5FVR2.
PRIDEQ5FVR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000040541; ENSRNOP00000039935; ENSRNOG00000032394.
GeneID315219.
KEGGrno:315219.

Organism-specific databases

CTD1890.
RGD1305756. Tymp.

Phylogenomic databases

eggNOGCOG0213.
GeneTreeENSGT00390000009250.
HOGENOMHOG000047313.
HOVERGENHBG000082.
InParanoidQ5FVR2.
KOK00758.
OMAESVPGFH.
OrthoDBEOG744T97.
PhylomeDBQ5FVR2.
TreeFamTF332198.

Enzyme and pathway databases

UniPathwayUPA00578; UER00638.

Gene expression databases

GenevestigatorQ5FVR2.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02644. Y_phosphoryl. 1 hit.
ProtoNetSearch...

Other

NextBio668926.
PROQ5FVR2.

Entry information

Entry nameTYPH_RAT
AccessionPrimary (citable) accession number: Q5FVR2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways