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Protein

Probable palmitoyltransferase ZDHHC4

Gene

Zdhhc4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC4 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 4
Short name:
DHHC-4
Gene namesi
Name:Zdhhc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308389. Zdhhc4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128671 – 343Probable palmitoyltransferase ZDHHC4Add BLAST343

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ5FVR1.

PTM databases

PhosphoSitePlusiQ5FVR1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 199DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ5FVR1.
KOiK20003.
PhylomeDBiQ5FVR1.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLVLFSFY LAFLLICVIM ICIFTKSQRL KAVVLGGAQV CARVTPQCFQ
60 70 80 90 100
RAVQTLLHQL FHTRHPAFLA LHLLLQGLVY AEYTYEVFSY CRELEFSLPC
110 120 130 140 150
LLLPYVLLSV NLVFFTLTCS TNPGTITKTN VLLLLQVYEF DEVMFPKNSR
160 170 180 190 200
CSTCDLRKPA RSKHCRVCDR CVHRFDHHCV WVNNCIGAWN TGYFLIYLLT
210 220 230 240 250
LTASAATIAI LSAAFLLRLV AVSNLYQETY LDDLGRFQAV DTGFLIQHLF
260 270 280 290 300
LAFPRIIFLL GFVIVLSLLL AGYLCFALYL AATNQTTNEW YRGDWAWCQH
310 320 330 340
WPLVAWSPSA EPQIHQNIYS HGLWSNLQEV FIPATPSYKK KKR
Length:343
Mass (Da):39,397
Last modified:March 1, 2005 - v1
Checksum:i429AF110422B217E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886523 mRNA. Translation: AAX73385.1.
BC089831 mRNA. Translation: AAH89831.1.
RefSeqiNP_001013141.1. NM_001013123.1.
UniGeneiRn.228619.

Genome annotation databases

GeneIDi304291.
KEGGirno:304291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886523 mRNA. Translation: AAX73385.1.
BC089831 mRNA. Translation: AAH89831.1.
RefSeqiNP_001013141.1. NM_001013123.1.
UniGeneiRn.228619.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001447.

PTM databases

PhosphoSitePlusiQ5FVR1.

Proteomic databases

PaxDbiQ5FVR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi304291.
KEGGirno:304291.

Organism-specific databases

CTDi55146.
RGDi1308389. Zdhhc4.

Phylogenomic databases

eggNOGiKOG1312. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000253024.
HOVERGENiHBG054775.
InParanoidiQ5FVR1.
KOiK20003.
PhylomeDBiQ5FVR1.

Miscellaneous databases

PROiPR:Q5FVR1.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC4_RAT
AccessioniPrimary (citable) accession number: Q5FVR1
Secondary accession number(s): Q2TGK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2005
Last modified: February 15, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.