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Protein

NLR family member X1

Gene

Nlrx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in antiviral signaling.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 171ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NLR family member X1
Gene namesi
Name:Nlrx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1311293. Nlrx1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 84MitochondrionBy similarityAdd BLAST84
ChainiPRO_000029619285 – 973NLR family member X1By similarityAdd BLAST889

Proteomic databases

PaxDbiQ5FVQ8.
PRIDEiQ5FVQ8.

PTM databases

iPTMnetiQ5FVQ8.
PhosphoSitePlusiQ5FVQ8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008771.

Interactioni

Subunit structurei

Homohexamer. Interacts with MAVS (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011620.

Structurei

3D structure databases

ProteinModelPortaliQ5FVQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 481NACHTPROSITE-ProRule annotationAdd BLAST324
Domaini665 – 692LRRNTAdd BLAST28
Repeati693 – 716LRR 1Add BLAST24
Repeati722 – 745LRR 2Add BLAST24
Repeati747 – 775LRR 3Add BLAST29
Repeati776 – 799LRR 4Add BLAST24
Repeati809 – 832LRR 5Add BLAST24
Repeati833 – 855LRR 6Add BLAST23
Repeati856 – 875LRR 7Add BLAST20
Repeati876 – 897LRR 8Add BLAST22
Domaini904 – 968LRRCTAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 554Required for interaction with MAVSBy similarityAdd BLAST482
Regioni554 – 972Required for the repression of MAVS-induced interferon signalingBy similarityAdd BLAST419

Domaini

The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.By similarity

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000113797.
HOVERGENiHBG106320.
InParanoidiQ5FVQ8.
KOiK12653.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWGCHLPRT SWGSGLGRTV PLPDELRIQS SWPFKGVHHP LRPPRAFIRH
60 70 80 90 100
HGNSADSAPP PGRHGQLFRS ISATEAIQRH RRNLTEWFSR LPREERQFGP
110 120 130 140 150
TFALDTVHVD PVIRESTPDD LLRPSTELAT GHQRTQAELP PLALSQLFDP
160 170 180 190 200
DACGRRVQTV VLYGTVGTGK STLVRKMVLD WCYGRLPAFE LLIPFSCEDL
210 220 230 240 250
SSLGSTPASL CQLVTQRYTP LKEVLPLMNA AGSRLLFVLH GLERLNLDFR
260 270 280 290 300
LAGTGLCSDP EEPGAPAAIM VNLLRKYMLP EASILVTTRP SAIGRIPSKY
310 320 330 340 350
VGRYGEICGF SDTNLQKLYF QLRLNQPDCG YGAGGTGVSV TPAQRDNLIQ
360 370 380 390 400
MLSRNLEGHH QIAAACFLPS YCWLVCATLH FLHAPTSAGQ TLTSIYTSFL
410 420 430 440 450
RLNFNGETLD STDPSNLSLM SYAARTMGKL AYEGVSSRKT YFSEEDVRGC
460 470 480 490 500
LEAGIKTEEE FQLLQIFRRD ALRFFLAPCV EPGHLGTFVF TVPAMQEYLA
510 520 530 540 550
ALYIVLGLRK TALQRVGKEV FEFVGRVGED VSLVLGIVAK LLPLRILPLL
560 570 580 590 600
FNLLKVVPRV FGRMVSKSRE AVAQAMVLEM FREEDYYNDD VLDQMGASIL
610 620 630 640 650
GVEGPRRHPD EPPEDEVFEL FPMFMSGLLS AHNRAVLAQL GCPIKNLDAL
660 670 680 690 700
ENAQAIKKKL GKMGRQVLPP SELLDHLFFH YEFQNQRFSA EVLGSLRQLN
710 720 730 740 750
LAGVRMTPLK CTVVASVLGS GRHPLDEVNL ASCQLDPAGL HTLMPVLLRA
760 770 780 790 800
RKLGLQLNNL GPEACRDLRD LLLHDQCQIT TLRLSNNPLT AAGVGVLMDG
810 820 830 840 850
LAGNTSVTHL SLLHTDLGDE GLELLAAQLD RNKQLQELNV AYNGAGDTVA
860 870 880 890 900
LALAKAARKH PSLELLHLYF NELSSEGRQV LRDLGGSGEG GARVVASLTE
910 920 930 940 950
GTAVSEYWSV ILSEVQRNLN SWDPVRVQRH LKLLLRDLED SRGATLNPWR
960 970
KAQLLRVESE VKTLLEQLGG SGH
Length:973
Mass (Da):107,590
Last modified:March 1, 2005 - v1
Checksum:i73B87B5A1B70DE9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089834 mRNA. Translation: AAH89834.1.
RefSeqiNP_001020181.1. NM_001025010.1.
UniGeneiRn.12444.

Genome annotation databases

GeneIDi315599.
KEGGirno:315599.
UCSCiRGD:1311293. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089834 mRNA. Translation: AAH89834.1.
RefSeqiNP_001020181.1. NM_001025010.1.
UniGeneiRn.12444.

3D structure databases

ProteinModelPortaliQ5FVQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011620.

PTM databases

iPTMnetiQ5FVQ8.
PhosphoSitePlusiQ5FVQ8.

Proteomic databases

PaxDbiQ5FVQ8.
PRIDEiQ5FVQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi315599.
KEGGirno:315599.
UCSCiRGD:1311293. rat.

Organism-specific databases

CTDi79671.
RGDi1311293. Nlrx1.

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
HOGENOMiHOG000113797.
HOVERGENiHBG106320.
InParanoidiQ5FVQ8.
KOiK12653.

Miscellaneous databases

PROiQ5FVQ8.

Gene expression databases

BgeeiENSRNOG00000008771.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLRX1_RAT
AccessioniPrimary (citable) accession number: Q5FVQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.