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Protein

Malectin

Gene

Mlec

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81CarbohydrateBy similarity1
Binding sitei103CarbohydrateBy similarity1
Binding sitei130CarbohydrateBy similarity1
Binding sitei131CarbohydrateBy similarity1
Binding sitei200Carbohydrate; NigeroseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-RNO-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-RNO-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiCBM57. Carbohydrate-Binding Module Family 57.

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:Mlec
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1307736. Mlec.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 268LumenalSequence analysisAdd BLAST238
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 291CytoplasmicSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001398431 – 291MalectinAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FVQ4.
PRIDEiQ5FVQ4.

PTM databases

iPTMnetiQ5FVQ4.
PhosphoSitePlusiQ5FVQ4.
SwissPalmiQ5FVQ4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021725.
ExpressionAtlasiQ5FVQ4. baseline and differential.
GenevisibleiQ5FVQ4. RN.

Interactioni

Protein-protein interaction databases

BioGridi257900. 1 interactor.
IntActiQ5FVQ4. 1 interactor.
MINTiMINT-4574081.
STRINGi10116.ENSRNOP00000035497.

Structurei

3D structure databases

ProteinModelPortaliQ5FVQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 237Poly-Glu8

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ5FVQ4.
PhylomeDBiQ5FVQ4.
TreeFamiTF314856.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPRAAEGA AVALLRLLLL LLLLPPELRD RGLGVAGAAG AGLPESVIWA
60 70 80 90 100
VNAGGEAHVD VHGIHFRKDP LEGRVGRASD YGMKLPILRS TPEDQILYQT
110 120 130 140 150
ERYNEETFGY EVPVKEEGDY VLVLKFAEVY FAQSQQKVFD VRLNGHVVVK
160 170 180 190 200
DLDIFDRVGH STAHDEIIPM SIRKGKLSVQ GEVSTFTGKL YIEFVKGYYD
210 220 230 240 250
NPKVCALYIM AGTVDDVPKL QPHPGLEKKE EEEEEEEYDE GSNLKRQTNK
260 270 280 290
NRVQSGPRTP NPYASDNSSL MFPILVAFGV FIPTLFCLCR L
Length:291
Mass (Da):32,418
Last modified:March 1, 2005 - v1
Checksum:i11FA9277048361BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089839 mRNA. Translation: AAH89839.1.
RefSeqiNP_001014005.1. NM_001013983.1.
UniGeneiRn.162140.

Genome annotation databases

EnsembliENSRNOT00000038395; ENSRNOP00000035497; ENSRNOG00000021725.
GeneIDi304543.
KEGGirno:304543.
UCSCiRGD:1307736. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089839 mRNA. Translation: AAH89839.1.
RefSeqiNP_001014005.1. NM_001013983.1.
UniGeneiRn.162140.

3D structure databases

ProteinModelPortaliQ5FVQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi257900. 1 interactor.
IntActiQ5FVQ4. 1 interactor.
MINTiMINT-4574081.
STRINGi10116.ENSRNOP00000035497.

Protein family/group databases

CAZyiCBM57. Carbohydrate-Binding Module Family 57.

PTM databases

iPTMnetiQ5FVQ4.
PhosphoSitePlusiQ5FVQ4.
SwissPalmiQ5FVQ4.

Proteomic databases

PaxDbiQ5FVQ4.
PRIDEiQ5FVQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000038395; ENSRNOP00000035497; ENSRNOG00000021725.
GeneIDi304543.
KEGGirno:304543.
UCSCiRGD:1307736. rat.

Organism-specific databases

CTDi9761.
RGDi1307736. Mlec.

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ5FVQ4.
PhylomeDBiQ5FVQ4.
TreeFamiTF314856.

Enzyme and pathway databases

ReactomeiR-RNO-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ5FVQ4.

Gene expression databases

BgeeiENSRNOG00000021725.
ExpressionAtlasiQ5FVQ4. baseline and differential.
GenevisibleiQ5FVQ4. RN.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLEC_RAT
AccessioniPrimary (citable) accession number: Q5FVQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.