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Protein

Malectin

Gene

Mlec

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81CarbohydrateBy similarity1
Binding sitei103CarbohydrateBy similarity1
Binding sitei130CarbohydrateBy similarity1
Binding sitei131CarbohydrateBy similarity1
Binding sitei200Carbohydrate; NigeroseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-RNO-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-RNO-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiCBM57 Carbohydrate-Binding Module Family 57

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:Mlec
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1307736 Mlec

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 268LumenalSequence analysisAdd BLAST238
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 291CytoplasmicSequence analysis2

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001398431 – 291MalectinAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FVQ4
PRIDEiQ5FVQ4

PTM databases

iPTMnetiQ5FVQ4
PhosphoSitePlusiQ5FVQ4
SwissPalmiQ5FVQ4

Expressioni

Gene expression databases

BgeeiENSRNOG00000021725
ExpressionAtlasiQ5FVQ4 baseline and differential
GenevisibleiQ5FVQ4 RN

Interactioni

Protein-protein interaction databases

BioGridi257900, 1 interactor
IntActiQ5FVQ4, 1 interactor
STRINGi10116.ENSRNOP00000035497

Structurei

3D structure databases

ProteinModelPortaliQ5FVQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 237Poly-Glu8

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593 Eukaryota
ENOG410XNU5 LUCA
GeneTreeiENSGT00390000016504
HOGENOMiHOG000290695
HOVERGENiHBG108138
InParanoidiQ5FVQ4
PhylomeDBiQ5FVQ4
TreeFamiTF314856

Family and domain databases

InterProiView protein in InterPro
IPR021720 Malectin
PfamiView protein in Pfam
PF11721 Malectin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPRAAEGA AVALLRLLLL LLLLPPELRD RGLGVAGAAG AGLPESVIWA
60 70 80 90 100
VNAGGEAHVD VHGIHFRKDP LEGRVGRASD YGMKLPILRS TPEDQILYQT
110 120 130 140 150
ERYNEETFGY EVPVKEEGDY VLVLKFAEVY FAQSQQKVFD VRLNGHVVVK
160 170 180 190 200
DLDIFDRVGH STAHDEIIPM SIRKGKLSVQ GEVSTFTGKL YIEFVKGYYD
210 220 230 240 250
NPKVCALYIM AGTVDDVPKL QPHPGLEKKE EEEEEEEYDE GSNLKRQTNK
260 270 280 290
NRVQSGPRTP NPYASDNSSL MFPILVAFGV FIPTLFCLCR L
Length:291
Mass (Da):32,418
Last modified:March 1, 2005 - v1
Checksum:i11FA9277048361BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089839 mRNA Translation: AAH89839.1
RefSeqiNP_001014005.1, NM_001013983.1
UniGeneiRn.162140

Genome annotation databases

EnsembliENSRNOT00000038395; ENSRNOP00000035497; ENSRNOG00000021725
GeneIDi304543
KEGGirno:304543
UCSCiRGD:1307736 rat

Similar proteinsi

Entry informationi

Entry nameiMLEC_RAT
AccessioniPrimary (citable) accession number: Q5FVQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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