Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter ZIP8

Gene

Slc39a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-RNO-442380 Zinc influx into cells by the SLC39 gene family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP8
Alternative name(s):
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8
Short name:
ZIP-8
Gene namesi
Name:Slc39a8
Synonyms:Zip8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308236 Slc39a8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 19HelicalSequence analysisAdd BLAST19
Topological domaini20 – 132CytoplasmicSequence analysisAdd BLAST113
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 160ExtracellularSequence analysis7
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 191CytoplasmicSequence analysis10
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 304ExtracellularSequence analysisAdd BLAST92
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 367CytoplasmicSequence analysisAdd BLAST42
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 390ExtracellularSequence analysis2
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 431CytoplasmicSequence analysisAdd BLAST20
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Topological domaini453 – 462ExtracellularSequence analysis10

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127091 – 462Zinc transporter ZIP8Add BLAST462

Proteomic databases

PaxDbiQ5FVQ0
PRIDEiQ5FVQ0

Expressioni

Gene expression databases

BgeeiENSRNOG00000012508
GenevisibleiQ5FVQ0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030977

Structurei

3D structure databases

SMRiQ5FVQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 350XEXPHE-motifBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 13Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000070225
HOVERGENiHBG108450
InParanoidiQ5FVQ0
KOiK14714
OMAiLFFFERT
OrthoDBiEOG091G064Y
PhylomeDBiQ5FVQ0
TreeFamiTF318470

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGRAVAGL LLLAATGLGR PSEGPELAFT EDVLRVFGAN QSLSAAQLGR
60 70 80 90 100
LLERLGAAPQ QGALELGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFTAI
110 120 130 140 150
CPAILQQLNF HPCEDPQKHS VKPSFSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ LIPEAFGFNP KIDNYVEKAV
210 220 230 240 250
AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE KAHQPKTLPL
260 270 280 290 300
PPVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKAESSS CTCLKGPKLS
310 320 330 340 350
EIGTIAWMIT LCDALHNFID GLAIGASYTL SLLQGLSTSI AILCEEFPHE
360 370 380 390 400
LGDFVILLNA GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL
410 420 430 440 450
AGGMFLYISL ADMFPEMNDM LREKVTGRQT DFTFFMIQNA GMLTGFTAIL
460
LITLYAGDIE LQ
Length:462
Mass (Da):50,171
Last modified:March 1, 2005 - v1
Checksum:i954467170797180F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089844 mRNA Translation: AAH89844.1
RefSeqiNP_001011952.1, NM_001011952.1
XP_006233418.1, XM_006233356.2
XP_006233419.1, XM_006233357.2
XP_017446276.1, XM_017590787.1
UniGeneiRn.28321

Genome annotation databases

EnsembliENSRNOT00000033413; ENSRNOP00000030977; ENSRNOG00000012508
GeneIDi295455
KEGGirno:295455

Similar proteinsi

Entry informationi

Entry nameiS39A8_RAT
AccessioniPrimary (citable) accession number: Q5FVQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health