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Protein

Zinc transporter ZIP8

Gene

Slc39a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-RNO-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP8
Alternative name(s):
Solute carrier family 39 member 8
Zrt- and Irt-like protein 8
Short name:
ZIP-8
Gene namesi
Name:Slc39a8
Synonyms:Zip8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308236. Slc39a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 1919HelicalSequence analysisAdd
BLAST
Topological domaini20 – 132113CytoplasmicSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Topological domaini154 – 1607ExtracellularSequence analysis
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 19110CytoplasmicSequence analysis
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 30492ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Topological domaini326 – 36742CytoplasmicSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST
Topological domaini389 – 3902ExtracellularSequence analysis
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Topological domaini412 – 43120CytoplasmicSequence analysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence analysisAdd
BLAST
Topological domaini453 – 46210ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Zinc transporter ZIP8PRO_0000312709Add
BLAST

Proteomic databases

PaxDbiQ5FVQ0.
PRIDEiQ5FVQ0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000012508.
GenevisibleiQ5FVQ0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030977.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 3506XEXPHE-motifBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 134Poly-Leu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ5FVQ0.
KOiK14714.
OMAiFFVERVL.
OrthoDBiEOG091G064Y.
PhylomeDBiQ5FVQ0.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGRAVAGL LLLAATGLGR PSEGPELAFT EDVLRVFGAN QSLSAAQLGR
60 70 80 90 100
LLERLGAAPQ QGALELGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFTAI
110 120 130 140 150
CPAILQQLNF HPCEDPQKHS VKPSFSEVWG YGFLSVTIIN LASLLGLILT
160 170 180 190 200
PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ LIPEAFGFNP KIDNYVEKAV
210 220 230 240 250
AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE KAHQPKTLPL
260 270 280 290 300
PPVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKAESSS CTCLKGPKLS
310 320 330 340 350
EIGTIAWMIT LCDALHNFID GLAIGASYTL SLLQGLSTSI AILCEEFPHE
360 370 380 390 400
LGDFVILLNA GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL
410 420 430 440 450
AGGMFLYISL ADMFPEMNDM LREKVTGRQT DFTFFMIQNA GMLTGFTAIL
460
LITLYAGDIE LQ
Length:462
Mass (Da):50,171
Last modified:March 1, 2005 - v1
Checksum:i954467170797180F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089844 mRNA. Translation: AAH89844.1.
RefSeqiNP_001011952.1. NM_001011952.1.
XP_006233418.1. XM_006233356.2.
XP_006233419.1. XM_006233357.2.
UniGeneiRn.28321.

Genome annotation databases

EnsembliENSRNOT00000033413; ENSRNOP00000030977; ENSRNOG00000012508.
GeneIDi295455.
KEGGirno:295455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089844 mRNA. Translation: AAH89844.1.
RefSeqiNP_001011952.1. NM_001011952.1.
XP_006233418.1. XM_006233356.2.
XP_006233419.1. XM_006233357.2.
UniGeneiRn.28321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030977.

Proteomic databases

PaxDbiQ5FVQ0.
PRIDEiQ5FVQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033413; ENSRNOP00000030977; ENSRNOG00000012508.
GeneIDi295455.
KEGGirno:295455.

Organism-specific databases

CTDi64116.
RGDi1308236. Slc39a8.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000070225.
HOVERGENiHBG108450.
InParanoidiQ5FVQ0.
KOiK14714.
OMAiFFVERVL.
OrthoDBiEOG091G064Y.
PhylomeDBiQ5FVQ0.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-RNO-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

PROiQ5FVQ0.

Gene expression databases

BgeeiENSRNOG00000012508.
GenevisibleiQ5FVQ0. RN.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A8_RAT
AccessioniPrimary (citable) accession number: Q5FVQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.