Q5FVN9 (Q5FVN9_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Zeta-chain (TCR) associated protein kinase EMBL AAH89855.1

Gene names

Name:

Zap70 EMBL AAH89855.1 RGD 3983

Organism

Rattus norvegicus (Rat) EMBL AAH89855.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020635 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS020635
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5FVN9 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: FA51C06728F6F00A	FASTA	614	69,809
	10 20 30 40 50 60 MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP 70 80 90 100 110 120 IERQLNGTYA IAGGKAHCGP AELCQFYSQD PDGLPCNLRK PCNRPPGLEP QPGVFDCLRD 130 140 150 160 170 180 AMVRDYVRQT WKLEGDALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG 190 200 210 220 230 240 QQTDGKFLLR PRKEQGTYAL SLVYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK 250 260 270 280 290 300 LKADGLIYRL KEVCPNSSAS AEAAAPTLPA HPSTFTQPHR RIDTLNSDGY TPEPARLDKP 310 320 330 340 350 360 RPMPMDTSVY ESPYSDPEEL KDKKLFLKRE NLLVADIELG CGNFGSVRQG VYRMRKKQID 370 380 390 400 410 420 VAIKVLKQST EKADKDEMMR EAQIMHQLDN PYIVRLIGVC QAEALMLVME MAGGGPLHKF 430 440 450 460 470 480 LIGKKEEIPV SNVAELLHQV AMGMKYLEEK NFVHRDLAAR NVLLVNRHYA KISDFGLSKA 490 500 510 520 530 540 LGADDSYYTA RSAGKWPLKW YAPECINFRK FSSRSDVWSY GVTMWEAFSY GQKPYKKMKG 550 560 570 580 590 600 PEVLDFIKQG KRMECPPECP PEMYALMSDC WIYKWEDRPD FVAVEQRMRT YYYSMASRAE 610 GPPQCEQVAE AACG

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus EMBL AAH89855.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089855 mRNA. Translation: AAH89855.1.
IPI	IPI00357886.
RefSeq	NP_001012002.1. NM_001012002.1.
UniGene	Rn.17862.
3D structure databases
ProteinModelPortal	Q5FVN9.
SMR	Q5FVN9. Positions 2-601.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5FVN9.
PTM databases
PhosphoSite	Q5FVN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	301348.
KEGG	rno:301348.
NMPDR	fig|10116.3.peg.29884.
UCSC	NM_001012002. rat.
Organism-specific databases
CTD	7535.
RGD	3983. Zap70.
Phylogenomic databases
eggNOG	roNOG04941.
GeneTree	ENSGT00600000084269.
HOVERGEN	HBG001540.
InParanoid	Q5FVN9.
OrthoDB	EOG4NZTSX.
PhylomeDB	Q5FVN9.
Gene expression databases
ArrayExpress	Q5FVN9.
Genevestigator	Q5FVN9.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR023420. Kinase_SYK/ZAP-70_inter-SH2. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR012234. Tyr_kinase_non-rcpt_SYK/ZAP70. [Graphical view]
Gene3D	G3DSA:1.10.930.10. G3DSA:1.10.930.10. 1 hit. G3DSA:3.30.505.10. SH2. 2 hits.
KO	K07360.
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 2 hits. [Graphical view]
PIRSF	PIRSF000604. TyrPK_SYK. 1 hit.
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	648571.

Entry information

Entry name

Q5FVN9_RAT

Accession

Primary (citable) accession number: Q5FVN9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)