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Protein

Starch-binding domain-containing protein 1

Gene

Stbd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Carbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Starch-binding domain-containing protein 11 Publication
Alternative name(s):
Genethonin-11 Publication
Glycophagy cargo receptor stbd1Curated
Gene namesi
Name:Stbd11 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1311800. Stbd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence analysis
Transmembranei7 – 2317HelicalSequence analysisAdd
BLAST
Topological domaini24 – 333310CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Starch-binding domain-containing protein 1PRO_0000238962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671PhosphoserineCombined sources
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei192 – 1921PhosphoserineBy similarity
Modified residuei201 – 2011PhosphoserineCombined sources
Modified residuei205 – 2051PhosphoserineBy similarity
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei216 – 2161PhosphoserineCombined sources
Modified residuei219 – 2191PhosphoserineCombined sources

Post-translational modificationi

Ubiquitinated, which leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5FVN1.
PRIDEiQ5FVN1.

PTM databases

iPTMnetiQ5FVN1.
PhosphoSiteiQ5FVN1.

Expressioni

Gene expression databases

GenevisibleiQ5FVN1. RN.

Interactioni

Subunit structurei

Interacts with the ATG8 family proteins GABARAP and GABARAPL1 (By similarity). Interacts with several glycogen-associated proteins, such as GYS2 (liver glycogen synthase), GDE (glycogen debranching enzyme), GBE1 (glycogen branching enzyme 1) and EPM2A (Laforin) (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5FVN1. 1 interaction.
MINTiMINT-4580439.

Structurei

3D structure databases

ProteinModelPortaliQ5FVN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini233 – 332100CBM20PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi181 – 1877LIRBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 6151Gly-richAdd
BLAST

Domaini

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.By similarity
The C-terminal CBM20 domain is required for the interaction with glycogen.1 Publication

Sequence similaritiesi

Contains 1 CBM20 (carbohydrate binding type-20) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ19. Eukaryota.
ENOG410Y3IB. LUCA.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiQ5FVN1.
OMAiMGAVWSA.
OrthoDBiEOG7W9RVP.
PhylomeDBiQ5FVN1.
TreeFamiTF338505.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVWSALLV GGGLAGALIL WLLRGDSGAP GKDGGAEPLK DAPPGEAAAP
60 70 80 90 100
GGGPGGGGSG GLSPEPSDRE LVSKAEHLRE SNGHLISESK DLGNLTEAQR
110 120 130 140 150
LQNVGNAREY VPVGKVPDTH SRANSETSRN QSPESRVGEW RLPKGHETAV
160 170 180 190 200
KVAGSVAEKL PSSSPLMDRA EAASLAQSAG HEDWEVVSRH SSWGSVGLGG
210 220 230 240 250
SLEASRLSLN QGMDESRNSL VGGGWEVDGK VVSVKPRQVS IQFKVHYSTS
260 270 280 290 300
TDVQFIAVTG DHESLGGWNT YIPLHYCKDG LWSHSVFLPA DTVVEWKFVL
310 320 330
VENKEVTRWE ECSNRRLQTG HEDKVVHGWW GIH
Length:333
Mass (Da):35,494
Last modified:March 1, 2005 - v1
Checksum:i65D081FB65EC04BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089867 mRNA. Translation: AAH89867.1.
RefSeqiNP_001014010.1. NM_001013988.1.
UniGeneiRn.1935.

Genome annotation databases

EnsembliENSRNOT00000003020; ENSRNOP00000003020; ENSRNOG00000002218.
GeneIDi305234.
KEGGirno:305234.
UCSCiRGD:1311800. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089867 mRNA. Translation: AAH89867.1.
RefSeqiNP_001014010.1. NM_001013988.1.
UniGeneiRn.1935.

3D structure databases

ProteinModelPortaliQ5FVN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5FVN1. 1 interaction.
MINTiMINT-4580439.

Protein family/group databases

CAZyiCBM20. Carbohydrate-Binding Module Family 20.

PTM databases

iPTMnetiQ5FVN1.
PhosphoSiteiQ5FVN1.

Proteomic databases

PaxDbiQ5FVN1.
PRIDEiQ5FVN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003020; ENSRNOP00000003020; ENSRNOG00000002218.
GeneIDi305234.
KEGGirno:305234.
UCSCiRGD:1311800. rat.

Organism-specific databases

CTDi8987.
RGDi1311800. Stbd1.

Phylogenomic databases

eggNOGiENOG410IJ19. Eukaryota.
ENOG410Y3IB. LUCA.
GeneTreeiENSGT00390000007731.
HOGENOMiHOG000065763.
HOVERGENiHBG048985.
InParanoidiQ5FVN1.
OMAiMGAVWSA.
OrthoDBiEOG7W9RVP.
PhylomeDBiQ5FVN1.
TreeFamiTF338505.

Miscellaneous databases

NextBioi654229.
PROiQ5FVN1.

Gene expression databases

GenevisibleiQ5FVN1. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR002044. CBM_fam20.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00686. CBM_20. 1 hit.
[Graphical view]
SMARTiSM01065. CBM_2. 1 hit.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 1 hit.
PROSITEiPS51166. CBM20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism."
    Jiang S., Heller B., Tagliabracci V.S., Zhai L., Irimia J.M., DePaoli-Roach A.A., Wells C.D., Skurat A.V., Roach P.J.
    J. Biol. Chem. 285:34960-34971(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DOMAIN, GLYCOGEN-BINDING, FUNCTION.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-162; SER-201; SER-208; SER-216 AND SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTBD1_RAT
AccessioniPrimary (citable) accession number: Q5FVN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2005
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.