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Protein

Lysophospholipid acyltransferase 5

Gene

Lpcat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381By similarity
Active sitei374 – 3741By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1482788. Acyl chain remodelling of PC.
R-RNO-1482801. Acyl chain remodelling of PS.
R-RNO-1482839. Acyl chain remodelling of PE.
UniPathwayiUPA00085.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid acyltransferase 5 (EC:2.3.1.-)
Short name:
LPLAT 5
Alternative name(s):
1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23)
Lysophosphatidylcholine acyltransferase 3
Short name:
Lyso-PC acyltransferase 3
Membrane-bound O-acyltransferase domain-containing protein 5
Short name:
O-acyltransferase domain-containing protein 5
Gene namesi
Name:Lpcat3
Synonyms:Grcc3fImported, Mboat5, Oact5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310223. Lpcat3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Transmembranei364 – 38421HelicalSequence analysisAdd
BLAST
Transmembranei422 – 44221HelicalSequence analysisAdd
BLAST
Transmembranei453 – 47321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 487486Lysophospholipid acyltransferase 5PRO_0000233384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ5FVN0.
PRIDEiQ5FVN0.

PTM databases

iPTMnetiQ5FVN0.

Expressioni

Gene expression databases

GenevisibleiQ5FVN0. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4580422.
STRINGi10116.ENSRNOP00000017090.

Structurei

3D structure databases

ProteinModelPortaliQ5FVN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi484 – 4874Di-lysine motif

Domaini

The di-lysine motif confers endoplasmic reticulum localization.By similarity

Sequence similaritiesi

Belongs to the membrane-bound acyltransferase family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2705. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000019529.
HOVERGENiHBG054659.
InParanoidiQ5FVN0.
KOiK13515.
OMAiIFSFRRY.
OrthoDBiEOG78SQJ0.
PhylomeDBiQ5FVN0.
TreeFamiTF106143.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTADGDVG ETLGQMRGLW PGVEDLSLNK LATSLGASEQ ALRLIFSIFL
60 70 80 90 100
GYPLALFYRH YLFYKDSYLI HLFHAFSGLS IAYFNFGHQF YHSLLCVVLQ
110 120 130 140 150
FLILRLMGRT ITAVFTTLCF QMAYLLAGYY YTATGDYDIK WTMPHCVLTL
160 170 180 190 200
KLIGLSIDYY DGGKDRNSLS SEQQKYAILG VPSLLEVAGF SYFYGAFLVG
210 220 230 240 250
PQFSMNHYMK LVKGQLTDVP GKMPNSTIPA LKRLSLGLVY LVGYTLLSPH
260 270 280 290 300
ITEDYLLTED YDTRPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILSGL
310 320 330 340 350
GFNGFEENGT VKWDACANMK VWLFETTPRF TGTIASFNIN TNAWVARYIF
360 370 380 390 400
KRLKFLGNKE LSQGLSLLFL ALWHGLHSGY LICFQMEFLI VIVEKQATNL
410 420 430 440 450
IRDSPALSSL ASITALQPFY YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV
460 470 480
YRSIYFLGHV FFLSLLFTLP YVYKAMVPRK EKLKKRE
Length:487
Mass (Da):56,018
Last modified:March 1, 2005 - v1
Checksum:i29F44D92190957A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089869 mRNA. Translation: AAH89869.1.
RefSeqiNP_001012189.1. NM_001012189.1.
UniGeneiRn.19543.

Genome annotation databases

EnsembliENSRNOT00000017090; ENSRNOP00000017090; ENSRNOG00000012269.
GeneIDi362434.
KEGGirno:362434.
UCSCiRGD:1310223. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089869 mRNA. Translation: AAH89869.1.
RefSeqiNP_001012189.1. NM_001012189.1.
UniGeneiRn.19543.

3D structure databases

ProteinModelPortaliQ5FVN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4580422.
STRINGi10116.ENSRNOP00000017090.

PTM databases

iPTMnetiQ5FVN0.

Proteomic databases

PaxDbiQ5FVN0.
PRIDEiQ5FVN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017090; ENSRNOP00000017090; ENSRNOG00000012269.
GeneIDi362434.
KEGGirno:362434.
UCSCiRGD:1310223. rat.

Organism-specific databases

CTDi10162.
RGDi1310223. Lpcat3.

Phylogenomic databases

eggNOGiKOG2705. Eukaryota.
COG5202. LUCA.
GeneTreeiENSGT00550000074565.
HOGENOMiHOG000019529.
HOVERGENiHBG054659.
InParanoidiQ5FVN0.
KOiK13515.
OMAiIFSFRRY.
OrthoDBiEOG78SQJ0.
PhylomeDBiQ5FVN0.
TreeFamiTF106143.

Enzyme and pathway databases

UniPathwayiUPA00085.
ReactomeiR-RNO-1482788. Acyl chain remodelling of PC.
R-RNO-1482801. Acyl chain remodelling of PS.
R-RNO-1482839. Acyl chain remodelling of PE.

Miscellaneous databases

PROiQ5FVN0.

Gene expression databases

GenevisibleiQ5FVN0. RN.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMBOA5_RAT
AccessioniPrimary (citable) accession number: Q5FVN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.