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Protein

Lysophospholipid acyltransferase 5

Gene

Lpcat3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity).By similarity

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.

Pathwayi: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338By similarity1
Active sitei374By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1482788 Acyl chain remodelling of PC
R-RNO-1482801 Acyl chain remodelling of PS
R-RNO-1482839 Acyl chain remodelling of PE
UniPathwayiUPA00085

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipid acyltransferase 5 (EC:2.3.1.-)
Short name:
LPLAT 5
Alternative name(s):
1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23)
Lysophosphatidylcholine acyltransferase 3
Short name:
Lyso-PC acyltransferase 3
Membrane-bound O-acyltransferase domain-containing protein 5
Short name:
O-acyltransferase domain-containing protein 5
Gene namesi
Name:Lpcat3
Synonyms:Grcc3fImported, Mboat5, Oact5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1310223 Lpcat3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Transmembranei364 – 384HelicalSequence analysisAdd BLAST21
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Transmembranei453 – 473HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002333842 – 487Lysophospholipid acyltransferase 5Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiQ5FVN0
PRIDEiQ5FVN0

PTM databases

iPTMnetiQ5FVN0
PhosphoSitePlusiQ5FVN0

Expressioni

Gene expression databases

BgeeiENSRNOG00000012269
GenevisibleiQ5FVN0 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017090

Structurei

3D structure databases

ProteinModelPortaliQ5FVN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi484 – 487Di-lysine motif4

Domaini

The di-lysine motif confers endoplasmic reticulum localization.By similarity

Sequence similaritiesi

Belongs to the membrane-bound acyltransferase family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2705 Eukaryota
COG5202 LUCA
GeneTreeiENSGT00550000074565
HOGENOMiHOG000019529
HOVERGENiHBG054659
InParanoidiQ5FVN0
KOiK13515
OMAiTMPHCIL
OrthoDBiEOG091G062X
PhylomeDBiQ5FVN0
TreeFamiTF106143

Family and domain databases

InterProiView protein in InterPro
IPR004299 MBOAT_fam
PfamiView protein in Pfam
PF03062 MBOAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTADGDVG ETLGQMRGLW PGVEDLSLNK LATSLGASEQ ALRLIFSIFL
60 70 80 90 100
GYPLALFYRH YLFYKDSYLI HLFHAFSGLS IAYFNFGHQF YHSLLCVVLQ
110 120 130 140 150
FLILRLMGRT ITAVFTTLCF QMAYLLAGYY YTATGDYDIK WTMPHCVLTL
160 170 180 190 200
KLIGLSIDYY DGGKDRNSLS SEQQKYAILG VPSLLEVAGF SYFYGAFLVG
210 220 230 240 250
PQFSMNHYMK LVKGQLTDVP GKMPNSTIPA LKRLSLGLVY LVGYTLLSPH
260 270 280 290 300
ITEDYLLTED YDTRPFWFRC MYMLIWGKFV LYKYVTCWLV TEGVCILSGL
310 320 330 340 350
GFNGFEENGT VKWDACANMK VWLFETTPRF TGTIASFNIN TNAWVARYIF
360 370 380 390 400
KRLKFLGNKE LSQGLSLLFL ALWHGLHSGY LICFQMEFLI VIVEKQATNL
410 420 430 440 450
IRDSPALSSL ASITALQPFY YLVQQTIHWL FMGYSMTAFC LFTWDKWLKV
460 470 480
YRSIYFLGHV FFLSLLFTLP YVYKAMVPRK EKLKKRE
Length:487
Mass (Da):56,018
Last modified:March 1, 2005 - v1
Checksum:i29F44D92190957A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089869 mRNA Translation: AAH89869.1
RefSeqiNP_001012189.1, NM_001012189.1
XP_017448194.1, XM_017592705.1
UniGeneiRn.19543

Genome annotation databases

EnsembliENSRNOT00000017090; ENSRNOP00000017090; ENSRNOG00000012269
GeneIDi362434
KEGGirno:362434
UCSCiRGD:1310223 rat

Similar proteinsi

Entry informationi

Entry nameiMBOA5_RAT
AccessioniPrimary (citable) accession number: Q5FVN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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