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Protein

Myotubularin-related protein 12

Gene

Mtmr12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 12
Alternative name(s):
Phosphatidylinositol 3-phosphatase-associated protein
Gene namesi
Name:Mtmr12
Synonyms:Pip3ap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307902. Mtmr12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158271 – 748Myotubularin-related protein 12Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei565PhosphoserineBy similarity1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVM6.
PRIDEiQ5FVM6.

PTM databases

iPTMnetiQ5FVM6.
PhosphoSitePlusiQ5FVM6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000022929.

Interactioni

Subunit structurei

Interacts with myotubularin MTM1 and myotubularin-related MTMR2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036677.

Structurei

3D structure databases

ProteinModelPortaliQ5FVM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 644Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST439

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni450 – 559Interaction with MTM1By similarityAdd BLAST110

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00860000133763.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ5FVM6.
KOiK18085.
OMAiNDITLQC.
OrthoDBiEOG091G0DYN.
PhylomeDBiQ5FVM6.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030576. MTMR12.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF37. PTHR10807:SF37. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5FVM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TNEKEVTEKE EVTLHLLPGE
60 70 80 90 100
QLLCEASTVL KYVQEDSCQL GICGRLVCTD FRISFLGDEG SAVDNGAETH
110 120 130 140 150
FKNKIIGVND IPLHCVDQIY GVFDEKKKPL FGQLKKYPEK LVIHCKDLRV
160 170 180 190 200
LHFCLRYTKE EEVKRIVSGI IHHTQSPKLL KRLFLFSYAA AVHGTAADPR
210 220 230 240 250
NCTVMFDTPK DWCWELERTK GSVKYKTVSV NEGYRVCDRL PAYFVVPTPL
260 270 280 290 300
LEDDVKRFQG RGIPIWCWSC HNGSALLKMS ALPKEQDDSA LQIQKSFLDG
310 320 330 340 350
IYKTIHRPPY EMVKTEDLSS NFLSLQEIQS SYCKFKQLFL IDSSSEFWDT
360 370 380 390 400
DVKWFSLLES SGWLDIIRRC LKRAIEIIEC LEAQNMNVLL LEENASDLCC
410 420 430 440 450
LLSSLVQVMM DAHCRTWTGF QSLIQKEWVM GGHSFLDRCN HLHQSDKEEV
460 470 480 490 500
PVFLLFLDCV WQLVHQHPPA FEFTETYLTV LSDSLYIPIF STFFFNSPHQ
510 520 530 540 550
KDTNMGRESL DAQSKPLTLL TVWDWSVQFE PKAQTLLRNP LYVEKPKLDK
560 570 580 590 600
GQRKGSRFKH QRQLSLPLTQ SKSSPKRGFF REETDHLIKN LLGKRISKLI
610 620 630 640 650
NSSDDLQDNS REFYDNWHSK PTDYHGLLLP HIEGPEIKVW AQRYLRWIPE
660 670 680 690 700
AQILGGGRVA TMGKLLEMME EVQSLQEKIE ARHHRQEAIH VQAPGLLRNS
710 720 730 740
ARLSSLFPFA MHQRHSAKPV LPTSGWKALG GEDDLAKRED EFVDLGDV
Length:748
Mass (Da):85,686
Last modified:January 15, 2008 - v2
Checksum:i3001DA217CB3DC7D
GO
Isoform 2 (identifier: Q5FVM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-587: HQRQLSLPLTQSKSSPKRGFFREETDHL → VRCAVLTPPHPHLHQLLHPVYVRTKATL
     588-748: Missing.

Show »
Length:587
Mass (Da):67,211
Checksum:i7CD4D54CC156EE1F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030724560 – 587HQRQL…ETDHL → VRCAVLTPPHPHLHQLLHPV YVRTKATL in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_030725588 – 748Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012204 Genomic DNA. No translation available.
BC089876 mRNA. Translation: AAH89876.1.
RefSeqiNP_001012077.1. NM_001012077.1. [Q5FVM6-2]
XP_006232108.1. XM_006232046.3. [Q5FVM6-1]
UniGeneiRn.214625.

Genome annotation databases

EnsembliENSRNOT00000036633; ENSRNOP00000036677; ENSRNOG00000022929. [Q5FVM6-1]
GeneIDi310155.
KEGGirno:310155.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012204 Genomic DNA. No translation available.
BC089876 mRNA. Translation: AAH89876.1.
RefSeqiNP_001012077.1. NM_001012077.1. [Q5FVM6-2]
XP_006232108.1. XM_006232046.3. [Q5FVM6-1]
UniGeneiRn.214625.

3D structure databases

ProteinModelPortaliQ5FVM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036677.

PTM databases

iPTMnetiQ5FVM6.
PhosphoSitePlusiQ5FVM6.

Proteomic databases

PaxDbiQ5FVM6.
PRIDEiQ5FVM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000036633; ENSRNOP00000036677; ENSRNOG00000022929. [Q5FVM6-1]
GeneIDi310155.
KEGGirno:310155.

Organism-specific databases

CTDi54545.
RGDi1307902. Mtmr12.

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00860000133763.
HOGENOMiHOG000113684.
HOVERGENiHBG108154.
InParanoidiQ5FVM6.
KOiK18085.
OMAiNDITLQC.
OrthoDBiEOG091G0DYN.
PhylomeDBiQ5FVM6.
TreeFamiTF315197.

Miscellaneous databases

PROiQ5FVM6.

Gene expression databases

BgeeiENSRNOG00000022929.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030576. MTMR12.
IPR022587. MTMR12-like_C.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF37. PTHR10807:SF37. 1 hit.
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTMRC_RAT
AccessioniPrimary (citable) accession number: Q5FVM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks the phosphocysteine intermediate Cys active site in position 392 that is replaced by a Glu residue, preventing the hydrolase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.