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Protein

Myotubularin-related protein 12

Gene

Mtmr12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location.By similarity

Caution

Lacks the phosphocysteine intermediate Cys active site in position 392 that is replaced by a Glu residue, preventing the hydrolase activity.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1660516 Synthesis of PIPs at the early endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 12
Alternative name(s):
Phosphatidylinositol 3-phosphatase-associated protein
Gene namesi
Name:Mtmr12
Synonyms:Pip3ap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1307902 Mtmr12

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158271 – 748Myotubularin-related protein 12Add BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei565PhosphoserineBy similarity1
Modified residuei602PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVM6
PRIDEiQ5FVM6

PTM databases

iPTMnetiQ5FVM6
PhosphoSitePlusiQ5FVM6

Expressioni

Gene expression databases

BgeeiENSRNOG00000022929

Interactioni

Subunit structurei

Interacts with myotubularin MTM1 and myotubularin-related MTMR2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036677

Structurei

3D structure databases

ProteinModelPortaliQ5FVM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 644Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST439

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni450 – 559Interaction with MTM1By similarityAdd BLAST110

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000113684
HOVERGENiHBG108154
InParanoidiQ5FVM6
KOiK18085
OMAiPTSGWKA
OrthoDBiEOG091G0DYN
PhylomeDBiQ5FVM6
TreeFamiTF315197

Family and domain databases

InterProiView protein in InterPro
IPR030576 MTMR12
IPR022587 MTMR12-like_C
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF37 PTHR10807:SF37, 1 hit
PfamiView protein in Pfam
PF12578 3-PAP, 1 hit
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5FVM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TNEKEVTEKE EVTLHLLPGE
60 70 80 90 100
QLLCEASTVL KYVQEDSCQL GICGRLVCTD FRISFLGDEG SAVDNGAETH
110 120 130 140 150
FKNKIIGVND IPLHCVDQIY GVFDEKKKPL FGQLKKYPEK LVIHCKDLRV
160 170 180 190 200
LHFCLRYTKE EEVKRIVSGI IHHTQSPKLL KRLFLFSYAA AVHGTAADPR
210 220 230 240 250
NCTVMFDTPK DWCWELERTK GSVKYKTVSV NEGYRVCDRL PAYFVVPTPL
260 270 280 290 300
LEDDVKRFQG RGIPIWCWSC HNGSALLKMS ALPKEQDDSA LQIQKSFLDG
310 320 330 340 350
IYKTIHRPPY EMVKTEDLSS NFLSLQEIQS SYCKFKQLFL IDSSSEFWDT
360 370 380 390 400
DVKWFSLLES SGWLDIIRRC LKRAIEIIEC LEAQNMNVLL LEENASDLCC
410 420 430 440 450
LLSSLVQVMM DAHCRTWTGF QSLIQKEWVM GGHSFLDRCN HLHQSDKEEV
460 470 480 490 500
PVFLLFLDCV WQLVHQHPPA FEFTETYLTV LSDSLYIPIF STFFFNSPHQ
510 520 530 540 550
KDTNMGRESL DAQSKPLTLL TVWDWSVQFE PKAQTLLRNP LYVEKPKLDK
560 570 580 590 600
GQRKGSRFKH QRQLSLPLTQ SKSSPKRGFF REETDHLIKN LLGKRISKLI
610 620 630 640 650
NSSDDLQDNS REFYDNWHSK PTDYHGLLLP HIEGPEIKVW AQRYLRWIPE
660 670 680 690 700
AQILGGGRVA TMGKLLEMME EVQSLQEKIE ARHHRQEAIH VQAPGLLRNS
710 720 730 740
ARLSSLFPFA MHQRHSAKPV LPTSGWKALG GEDDLAKRED EFVDLGDV
Length:748
Mass (Da):85,686
Last modified:January 15, 2008 - v2
Checksum:i3001DA217CB3DC7D
GO
Isoform 2 (identifier: Q5FVM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-587: HQRQLSLPLTQSKSSPKRGFFREETDHL → VRCAVLTPPHPHLHQLLHPVYVRTKATL
     588-748: Missing.

Show »
Length:587
Mass (Da):67,211
Checksum:i7CD4D54CC156EE1F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030724560 – 587HQRQL…ETDHL → VRCAVLTPPHPHLHQLLHPV YVRTKATL in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_030725588 – 748Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03012204 Genomic DNA No translation available.
BC089876 mRNA Translation: AAH89876.1
RefSeqiNP_001012077.1, NM_001012077.1 [Q5FVM6-2]
XP_006232108.1, XM_006232046.3 [Q5FVM6-1]
UniGeneiRn.214625

Genome annotation databases

EnsembliENSRNOT00000036633; ENSRNOP00000036677; ENSRNOG00000022929 [Q5FVM6-1]
GeneIDi310155
KEGGirno:310155

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMTMRC_RAT
AccessioniPrimary (citable) accession number: Q5FVM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health