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Protein

Reticulophagy receptor FAM134B

Gene

Fam134b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulophagy receptor FAM134BCurated
Gene namesi
Name:Fam134b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1565003. Fam134b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 78LumenalCuratedAdd BLAST14
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 101CytoplasmicCurated2
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 191LumenalCuratedAdd BLAST69
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 480CytoplasmicBy similarityAdd BLAST268

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884681 – 480Reticulophagy receptor FAM134BAdd BLAST480

Proteomic databases

PaxDbiQ5FVM3.
PRIDEiQ5FVM3.

PTM databases

iPTMnetiQ5FVM3.
PhosphoSitePlusiQ5FVM3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010589.
ExpressionAtlasiQ5FVM3. baseline.
GenevisibleiQ5FVM3. RN.

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062258.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 216Reticulon homology domainBy similarityAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi436 – 441LIR motifBy similarity6

Domaini

The LIR motif interacts with ATG8 family proteins and is necessary to target the ER fragments to autophagosomes for lysosomal degradation.By similarity
The reticulon homology domain provides capacity to bend the membrane and promotes ER scission (By similarity). This domain does not show relevant similarities with reticulon domains, preventing any domain predictions within the protein sequence.By similarityCurated

Sequence similaritiesi

Belongs to the FAM134 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFP1. Eukaryota.
ENOG410XPQB. LUCA.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000050246.
HOVERGENiHBG071073.
InParanoidiQ5FVM3.
OMAiCISESCS.
PhylomeDBiQ5FVM3.

Family and domain databases

InterProiView protein in InterPro
IPR033358. FAM134B.
PANTHERiPTHR28659:SF6. PTHR28659:SF6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAPEEHA TQGCPATEEQ EPRPGVPGEE AGPEGAGPQV EEAAGRVAAA
60 70 80 90 100
LTWLLGEPVL WLGWRADELL SWKRPLRSLL AFLGANLLFW FLALTPWRVY
110 120 130 140 150
HLISVMILGR VIMQIIKDMV LSRARGAQLW RSLSESWEVI NSKPDERPRL
160 170 180 190 200
SHCIAESWMN FSIFLQEMSL FKQQSPGKFC LLVCSVCTFF TILGSYIPGV
210 220 230 240 250
ILSYLLLLFA FLCPLFKCND IGQKIYSKVK SILLKLDFGI GEYINQKKRE
260 270 280 290 300
RSEADKEKSH KDDSEIDFSA LCPKISLTVA AKELSVSDTD VSEVSWTDNG
310 320 330 340 350
TFNLSEGYTP QTDTSDDLDR PSEEVFSRDL SDFPSLENGA GTNDEDELSL
360 370 380 390 400
GLPTELKTKK QQLNSAHRPS KDRQSAAGLS LPLKSDQALH LMSNLAGDVI
410 420 430 440 450
TAAMTAAIKD QLEGARQALA QAAPTPGDDT DTEEGDDFEL LDQAELDQIE
460 470 480
SELGLTQDQG AEAQQSKKSS GFLSNLLGGH
Length:480
Mass (Da):52,782
Last modified:March 1, 2005 - v1
Checksum:iCA226070D013E00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089887 mRNA. Translation: AAH89887.1.
RefSeqiNP_001030084.1. NM_001034912.1.
XP_008759043.1. XM_008760821.2.
XP_008773314.1. XM_008775092.1.
UniGeneiRn.162560.

Genome annotation databases

EnsembliENSRNOT00000063951; ENSRNOP00000062258; ENSRNOG00000010589.
GeneIDi103689968.
619558.
KEGGirno:103689968.
rno:619558.
UCSCiRGD:1565003. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089887 mRNA. Translation: AAH89887.1.
RefSeqiNP_001030084.1. NM_001034912.1.
XP_008759043.1. XM_008760821.2.
XP_008773314.1. XM_008775092.1.
UniGeneiRn.162560.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062258.

PTM databases

iPTMnetiQ5FVM3.
PhosphoSitePlusiQ5FVM3.

Proteomic databases

PaxDbiQ5FVM3.
PRIDEiQ5FVM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000063951; ENSRNOP00000062258; ENSRNOG00000010589.
GeneIDi103689968.
619558.
KEGGirno:103689968.
rno:619558.
UCSCiRGD:1565003. rat.

Organism-specific databases

CTDi54463.
RGDi1565003. Fam134b.

Phylogenomic databases

eggNOGiENOG410IFP1. Eukaryota.
ENOG410XPQB. LUCA.
GeneTreeiENSGT00390000018047.
HOGENOMiHOG000050246.
HOVERGENiHBG071073.
InParanoidiQ5FVM3.
OMAiCISESCS.
PhylomeDBiQ5FVM3.

Miscellaneous databases

PROiQ5FVM3.

Gene expression databases

BgeeiENSRNOG00000010589.
ExpressionAtlasiQ5FVM3. baseline.
GenevisibleiQ5FVM3. RN.

Family and domain databases

InterProiView protein in InterPro
IPR033358. FAM134B.
PANTHERiPTHR28659:SF6. PTHR28659:SF6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF134B_RAT
AccessioniPrimary (citable) accession number: Q5FVM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2005
Last modified: March 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.