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Protein

Reticulophagy regulator 1

Gene

Retreg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons.By similarity

GO - Biological processi

Keywordsi

Biological processAutophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulophagy regulator 1
Alternative name(s):
Reticulophagy receptor 1Curated
Gene namesi
Name:Retreg1Imported
Synonyms:Fam134b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1565003 Retreg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 78LumenalCuratedAdd BLAST14
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 101CytoplasmicCurated2
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 191LumenalCuratedAdd BLAST69
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 480CytoplasmicBy similarityAdd BLAST268

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884681 – 480Reticulophagy regulator 1Add BLAST480

Proteomic databases

PaxDbiQ5FVM3
PRIDEiQ5FVM3

PTM databases

iPTMnetiQ5FVM3
PhosphoSitePlusiQ5FVM3

Expressioni

Gene expression databases

BgeeiENSRNOG00000010589
ExpressionAtlasiQ5FVM3 baseline and differential
GenevisibleiQ5FVM3 RN

Interactioni

Subunit structurei

Interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062258

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 216Reticulon homology domainBy similarityAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi436 – 441LIR motifBy similarity6

Domaini

The LIR motif interacts with ATG8 family proteins and is necessary to target the ER fragments to autophagosomes for lysosomal degradation.By similarity
The reticulon homology domain provides capacity to bend the membrane and promotes ER scission (By similarity). This domain does not show relevant similarities with reticulon domains, preventing any domain predictions within the protein sequence.By similarityCurated

Sequence similaritiesi

Belongs to the RETREG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFP1 Eukaryota
ENOG410XPQB LUCA
GeneTreeiENSGT00390000018047
HOGENOMiHOG000050246
HOVERGENiHBG071073
InParanoidiQ5FVM3
OMAiLSESWEV
PhylomeDBiQ5FVM3

Family and domain databases

InterProiView protein in InterPro
IPR033358 RETREG1
PANTHERiPTHR28659:SF3 PTHR28659:SF3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAPEEHA TQGCPATEEQ EPRPGVPGEE AGPEGAGPQV EEAAGRVAAA
60 70 80 90 100
LTWLLGEPVL WLGWRADELL SWKRPLRSLL AFLGANLLFW FLALTPWRVY
110 120 130 140 150
HLISVMILGR VIMQIIKDMV LSRARGAQLW RSLSESWEVI NSKPDERPRL
160 170 180 190 200
SHCIAESWMN FSIFLQEMSL FKQQSPGKFC LLVCSVCTFF TILGSYIPGV
210 220 230 240 250
ILSYLLLLFA FLCPLFKCND IGQKIYSKVK SILLKLDFGI GEYINQKKRE
260 270 280 290 300
RSEADKEKSH KDDSEIDFSA LCPKISLTVA AKELSVSDTD VSEVSWTDNG
310 320 330 340 350
TFNLSEGYTP QTDTSDDLDR PSEEVFSRDL SDFPSLENGA GTNDEDELSL
360 370 380 390 400
GLPTELKTKK QQLNSAHRPS KDRQSAAGLS LPLKSDQALH LMSNLAGDVI
410 420 430 440 450
TAAMTAAIKD QLEGARQALA QAAPTPGDDT DTEEGDDFEL LDQAELDQIE
460 470 480
SELGLTQDQG AEAQQSKKSS GFLSNLLGGH
Length:480
Mass (Da):52,782
Last modified:March 1, 2005 - v1
Checksum:iCA226070D013E00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089887 mRNA Translation: AAH89887.1
RefSeqiNP_001030084.1, NM_001034912.1
XP_008759043.1, XM_008760821.2
XP_008773314.1, XM_008775092.1
UniGeneiRn.162560

Genome annotation databases

EnsembliENSRNOT00000063951; ENSRNOP00000062258; ENSRNOG00000010589
GeneIDi103689968
619558
KEGGirno:103689968
rno:619558
UCSCiRGD:1565003 rat

Similar proteinsi

Entry informationi

Entry nameiRETR1_RAT
AccessioniPrimary (citable) accession number: Q5FVM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome