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Protein

Tetraspanin-13

Gene

Tspan13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Transmembrane 4 superfamily member 13
Gene namesi
Name:Tspan13
Synonyms:Tm4sf13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1311788. Tspan13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 44ExtracellularSequence analysis4
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 167ExtracellularSequence analysisAdd BLAST74
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 204CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192601 – 204Tetraspanin-13Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)By similarity1
Glycosylationi137N-linked (GlcNAc...)By similarity1
Modified residuei143PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5FVL6.
PRIDEiQ5FVL6.

PTM databases

iPTMnetiQ5FVL6.
PhosphoSitePlusiQ5FVL6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000005046.
GenevisibleiQ5FVL6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006752.

Structurei

3D structure databases

ProteinModelPortaliQ5FVL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ5FVL6.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ5FVL6.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFSCSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
REQQGQLLEV GWNNTASARN DIQRNLNCCG FRNYNPNDTC PASCAKSNQK
160 170 180 190 200
CSSCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,259
Last modified:March 1, 2005 - v1
Checksum:iEF8A4E08D8CAE5E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089906 mRNA. Translation: AAH89906.1.
RefSeqiNP_001013262.1. NM_001013244.1.
UniGeneiRn.24284.

Genome annotation databases

EnsembliENSRNOT00000006752; ENSRNOP00000006752; ENSRNOG00000005046.
GeneIDi366602.
KEGGirno:366602.
UCSCiRGD:1311788. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089906 mRNA. Translation: AAH89906.1.
RefSeqiNP_001013262.1. NM_001013244.1.
UniGeneiRn.24284.

3D structure databases

ProteinModelPortaliQ5FVL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006752.

PTM databases

iPTMnetiQ5FVL6.
PhosphoSitePlusiQ5FVL6.

Proteomic databases

PaxDbiQ5FVL6.
PRIDEiQ5FVL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006752; ENSRNOP00000006752; ENSRNOG00000005046.
GeneIDi366602.
KEGGirno:366602.
UCSCiRGD:1311788. rat.

Organism-specific databases

CTDi27075.
RGDi1311788. Tspan13.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiQ5FVL6.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiQ5FVL6.
TreeFamiTF323367.

Miscellaneous databases

PROiQ5FVL6.

Gene expression databases

BgeeiENSRNOG00000005046.
GenevisibleiQ5FVL6. RN.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN13_RAT
AccessioniPrimary (citable) accession number: Q5FVL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.