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Protein

ARL14 effector protein

Gene

Arl14ep

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
ARL14 effector protein
Alternative name(s):
ARF7 effector protein
Gene namesi
Name:Arl14ep
Synonyms:Arf7ep
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1311463. Arl14ep.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002518941 – 276ARL14 effector proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei182PhosphoserineBy similarity1
Modified residuei266PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5FVK8.
PRIDEiQ5FVK8.

PTM databases

iPTMnetiQ5FVK8.
PhosphoSitePlusiQ5FVK8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004891.
GenevisibleiQ5FVK8. RN.

Interactioni

Subunit structurei

Interacts with ARL14 and MYO1E.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006481.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi208 – 236Cys-richAdd BLAST29

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ5FVK8.
OMAiQFANPGR.
OrthoDBiEOG091G0X7Y.
PhylomeDBiQ5FVK8.
TreeFamiTF333216.

Family and domain databases

InterProiView protein in InterPro
IPR029264. ARF7EP_C.
IPR026515. ARL14EP.
PANTHERiPTHR23080:SF91. PTHR23080:SF91. 1 hit.
PfamiView protein in Pfam
PF14949. ARF7EP_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPCSVGVQL RTTHDCHKTF YTRHTGFKTL KELSSNDMLL LQLRTGMTLS
60 70 80 90 100
GNNTICLHHV KIYIERFEEL QKSCCDPFNI HKKLAKKNLH VIDLDDATFL
110 120 130 140 150
SAKFGRQLVP GWKLCPKCTQ IINGSVDVDS DDRQRRKPES DGRTAKALRS
160 170 180 190 200
LQFTNPGKQT EFAPESGKRE KRKLTKNASA SSDRQIIPAK SKVYDSQGLL
210 220 230 240 250
IFSGMDLCDC LDEDCLGCFY ACPTCGSTKC GAECRCDRKW LYEQIEIEGG
260 270
EIIHNKHAGK AYGLLSPCHP YDILQK
Length:276
Mass (Da):31,112
Last modified:March 1, 2005 - v1
Checksum:iA79E194DF5DED2AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089920 mRNA. Translation: AAH89920.1.
RefSeqiNP_001014067.1. NM_001014045.1.
XP_008760314.1. XM_008762092.2.
UniGeneiRn.40865.

Genome annotation databases

EnsembliENSRNOT00000006481; ENSRNOP00000006481; ENSRNOG00000004891.
GeneIDi311279.
KEGGirno:311279.
UCSCiRGD:1311463. rat.

Similar proteinsi

Entry informationi

Entry nameiAL14E_RAT
AccessioniPrimary (citable) accession number: Q5FVK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2005
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome