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Protein

Coiled-coil and C2 domain-containing protein 1B

Gene

Cc2d1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil and C2 domain-containing protein 1B
Alternative name(s):
Five prime repressor element under dual repression-binding protein 2
Short name:
FRE under dual repression-binding protein 2
Short name:
Freud-2
Gene namesi
Name:Cc2d1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1306630. Cc2d1b.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Ensembl
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 850850Coiled-coil and C2 domain-containing protein 1BPRO_0000288428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei585 – 5851PhosphoserineBy similarity
Modified residuei588 – 5881PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVK6.
PRIDEiQ5FVK6.

PTM databases

iPTMnetiQ5FVK6.

Expressioni

Tissue specificityi

Expressed in epididymal sperm but not in testicular sperm (at protein level).1 Publication

Gene expression databases

GenevisibleiQ5FVK6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011670.

Structurei

3D structure databases

ProteinModelPortaliQ5FVK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini678 – 791114C2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili167 – 21347Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 978Poly-Glu

Sequence similaritiesi

Belongs to the CC2D1 family.Curated
Contains 1 C2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ5FVK6.
KOiK18260.
OMAiMVTENWL.
OrthoDBiEOG71G9TB.
PhylomeDBiQ5FVK6.
TreeFamiTF314229.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5FVK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGPRPRKGP KTSGQGAETA KQLGLFVEFN PEDMLLGMDE TEDDGDLEAE
60 70 80 90 100
LLALTGETGS TSRKPAPKGR APLPMAHIEK LAADCMRDVE EEGEEEEGLE
110 120 130 140 150
DDADLLTELQ EVLGVDEETG LVDDSEETSP DLSEEKTRDN TEQPVAPAAF
160 170 180 190 200
QQALPAAVAQ AGGPRGLQAL LEERIQNYRE AAASAKEAGE AAKARRCERG
210 220 230 240 250
LKTLESQLAT VRKGGKICED EIPPPVALGK RPPAHQERPS KDSEIDSAGS
260 270 280 290 300
CAMDPGDLSQ PESSLPAVAA LPDSDPDPQA LLLARQREYK AAALSAKRAG
310 320 330 340 350
DLDRARELMR IGKRFGTVLE ALEKGQPVDL SGMPPAPEDL KALPQASEAS
360 370 380 390 400
AATQVLSPAV EQMQPVMSSD LPATPAAPAE PKTVLDALQQ RLNRYREAGI
410 420 430 440 450
QARASGDERK ARMHDRIAKQ YQDAIRAHQA GRKVDFAELP VPPGFPPIPG
460 470 480 490 500
LEPRKDTEED SVTATLAAAQ KLASEDTALV DEDEERDTPA QAPLAKKPAQ
510 520 530 540 550
PLVPSSHLLN EPKASSSKES LSPSVREQVT LLEARKLQYQ RAALQAKRRQ
560 570 580 590 600
DLEQAKSHLR VAKSLEAQII QARAGQPIDL SKVPSPLTDE EGDFILIHHE
610 620 630 640 650
DLRLSQKAEE VYAQLQKILL EQHEKCLLFS KQFMHQGNVA ETTRFEKLAE
660 670 680 690 700
DRKKQLEILQ LAQAQGLDPP SHHFELKTLQ TVRIFSELNS TEMHLIIVRG
710 720 730 740 750
MNLPAPPGVT PDDLDAFVRF EFHYPNSDQA QKSKTAVVKN TNSPEFEQVF
760 770 780 790 800
KLNINRNHRG FRRVIQSKGI KFEIFHKGSF FRSDKLVGTA HLKLERLEKE
810 820 830 840 850
CEIREIMEVL DGRKPTGGKL EVKVRLREPL SSQDVQMVTE NWLVLEPRGL
Length:850
Mass (Da):93,534
Last modified:May 29, 2007 - v2
Checksum:i2132241D45424146
GO
Isoform 2 (identifier: Q5FVK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-692: Missing.

Show »
Length:158
Mass (Da):18,238
Checksum:i20C96FD1085CB3A4
GO

Mass spectrometryi

Molecular mass is 93476.08 Da from positions 1 - 850. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 692692Missing in isoform 2. 1 PublicationVSP_025664Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040177 Genomic DNA. No translation available.
BC089922 mRNA. Translation: AAH89922.1.
RefSeqiNP_001257913.1. NM_001270984.1. [Q5FVK6-1]
UniGeneiRn.3265.

Genome annotation databases

EnsembliENSRNOT00000011670; ENSRNOP00000011670; ENSRNOG00000008634. [Q5FVK6-1]
GeneIDi313478.
KEGGirno:313478.
UCSCiRGD:1306630. rat. [Q5FVK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040177 Genomic DNA. No translation available.
BC089922 mRNA. Translation: AAH89922.1.
RefSeqiNP_001257913.1. NM_001270984.1. [Q5FVK6-1]
UniGeneiRn.3265.

3D structure databases

ProteinModelPortaliQ5FVK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011670.

PTM databases

iPTMnetiQ5FVK6.

Proteomic databases

PaxDbiQ5FVK6.
PRIDEiQ5FVK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011670; ENSRNOP00000011670; ENSRNOG00000008634. [Q5FVK6-1]
GeneIDi313478.
KEGGirno:313478.
UCSCiRGD:1306630. rat. [Q5FVK6-1]

Organism-specific databases

CTDi200014.
RGDi1306630. Cc2d1b.

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ5FVK6.
KOiK18260.
OMAiMVTENWL.
OrthoDBiEOG71G9TB.
PhylomeDBiQ5FVK6.
TreeFamiTF314229.

Miscellaneous databases

PROiQ5FVK6.

Gene expression databases

GenevisibleiQ5FVK6. RN.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovary.
  3. "Differential proteomics leads to identification of domain specific epididymal sperm proteins."
    Suryawanshi A.R., Khan S.A., Gajbhiye R.K., Gurav M.Y., Khole V.V.
    J. Androl. 32:240-259(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Strain: Holtzman.
    Tissue: Sperm.

Entry informationi

Entry nameiC2D1B_RAT
AccessioniPrimary (citable) accession number: Q5FVK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 8, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.