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Protein

Seipin

Gene

Bscl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Seipin
Alternative name(s):
Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog
Gene namesi
Name:Bscl2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308135. Bscl2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 242LumenalSequence analysisAdd BLAST194
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 377CytoplasmicSequence analysisAdd BLAST114

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916811 – 377SeipinAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)By similarity1
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Modified residuei289PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ5FVJ6.
PRIDEiQ5FVJ6.

PTM databases

iPTMnetiQ5FVJ6.
PhosphoSitePlusiQ5FVJ6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019636.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061399.

Family & Domainsi

Sequence similaritiesi

Belongs to the seipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4200. Eukaryota.
ENOG4111GRP. LUCA.
HOVERGENiHBG050736.
InParanoidiQ5FVJ6.
KOiK19365.
PhylomeDBiQ5FVJ6.

Family and domain databases

InterProiIPR009617. Seipin.
[Graphical view]
PfamiPF06775. Seipin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNDPPVPAL LWAQEVGHVL AGRARRLMLQ FGVLFCTILL LLWVSVFLYG
60 70 80 90 100
SFYYSYMPTV SHLSPVHFYY RTDCDSSTAS LCSFPVANVS LTKSGRDRVL
110 120 130 140 150
MYGQPYRVTL ELELPESPVN QDLGMFLVTV SCYTRGGRII STSSRSVMLH
160 170 180 190 200
YRSQLLQMLD TLVFSSLLLF GFAEQKQLLE VELYSDYREN SYVPTTGAII
210 220 230 240 250
EVHSKRVQMY GAYLRIHAHF TGLRYLLYNF PMTCAFVGVA SNFTFLSVIA
260 270 280 290 300
LFSYMQWVWG AVWPRHRFSL QVNIRQRDNS GHGAQRRISR HQPGQASTQQ
310 320 330 340 350
SDVTEDGESP EDPSGTEGQL SEEEKPEKQP LNGEGEQEPE ASDGSWEDAA
360 370
LLTEASTSAL APETLGSLRQ RQTCSSS
Length:377
Mass (Da):42,409
Last modified:March 1, 2005 - v1
Checksum:i38118CF3C0779E35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089942 mRNA. Translation: AAH89942.1.
RefSeqiNP_001012171.1. NM_001012171.1.
UniGeneiRn.105761.

Genome annotation databases

GeneIDi361722.
KEGGirno:361722.
UCSCiRGD:1308135. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089942 mRNA. Translation: AAH89942.1.
RefSeqiNP_001012171.1. NM_001012171.1.
UniGeneiRn.105761.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061399.

PTM databases

iPTMnetiQ5FVJ6.
PhosphoSitePlusiQ5FVJ6.

Proteomic databases

PaxDbiQ5FVJ6.
PRIDEiQ5FVJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi361722.
KEGGirno:361722.
UCSCiRGD:1308135. rat.

Organism-specific databases

CTDi26580.
RGDi1308135. Bscl2.

Phylogenomic databases

eggNOGiKOG4200. Eukaryota.
ENOG4111GRP. LUCA.
HOVERGENiHBG050736.
InParanoidiQ5FVJ6.
KOiK19365.
PhylomeDBiQ5FVJ6.

Miscellaneous databases

PROiQ5FVJ6.

Gene expression databases

BgeeiENSRNOG00000019636.

Family and domain databases

InterProiIPR009617. Seipin.
[Graphical view]
PfamiPF06775. Seipin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBSCL2_RAT
AccessioniPrimary (citable) accession number: Q5FVJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.