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Protein

Inactive phospholipid phosphatase 7

Gene

Plpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipid phosphatase 7Imported
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Gene namesi
Name:Plpp7Imported
Synonyms:Ppapdc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1305821. Plpp7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 112112CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 1418ExtracellularSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 20240CytoplasmicSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 23916ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 27111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Inactive phospholipid phosphatase 7PRO_0000239403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVJ3.
PRIDEiQ5FVJ3.

Expressioni

Gene expression databases

GenevisibleiQ5FVJ3. RN.

Interactioni

Subunit structurei

Homo- and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013507.

Structurei

3D structure databases

ProteinModelPortaliQ5FVJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 9122Interaction with MTORBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ5FVJ3.
OMAiLWAFCVG.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ5FVJ3.
TreeFamiTF323272.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSQSRARA RDRNNVLNRA EFLSLNQPPK GTQEPRSSGR KASGPSTQPP
60 70 80 90 100
PSSDGARERR QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA
110 120 130 140 150
GRAASWASAR SMVKLIGITS HGIPWIGGTI LCLVRSSTLA GQEVLMNLLL
160 170 180 190 200
ALLLDIMTVA GVQKLIKRRG PYETSPGLLD YLTMDIYAFP AGHASRAAMV
210 220 230 240 250
SKFFLSHLVL AVPLRVLLVL WAFCVGLSRV MIGRHHITDV ISGFIIGYFQ
260 270
FRLVELVWMS SNTCQMLISA W
Length:271
Mass (Da):29,768
Last modified:March 1, 2005 - v1
Checksum:i531FE032F4502353
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089948 mRNA. Translation: AAH89948.1.
RefSeqiNP_001012349.1. NM_001012349.2.
UniGeneiRn.24087.

Genome annotation databases

EnsembliENSRNOT00000013507; ENSRNOP00000013507; ENSRNOG00000010068.
GeneIDi296635.
KEGGirno:296635.
UCSCiRGD:1305821. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089948 mRNA. Translation: AAH89948.1.
RefSeqiNP_001012349.1. NM_001012349.2.
UniGeneiRn.24087.

3D structure databases

ProteinModelPortaliQ5FVJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013507.

Proteomic databases

PaxDbiQ5FVJ3.
PRIDEiQ5FVJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013507; ENSRNOP00000013507; ENSRNOG00000010068.
GeneIDi296635.
KEGGirno:296635.
UCSCiRGD:1305821. rat.

Organism-specific databases

CTDi84814.
RGDi1305821. Plpp7.

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ5FVJ3.
OMAiLWAFCVG.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ5FVJ3.
TreeFamiTF323272.

Miscellaneous databases

PROiQ5FVJ3.

Gene expression databases

GenevisibleiQ5FVJ3. RN.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPLPP7_RAT
AccessioniPrimary (citable) accession number: Q5FVJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.