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Protein

Dual specificity protein phosphatase 26

Gene

Dusp26

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dusp26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1310090 Dusp26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002922221 – 211Dual specificity protein phosphatase 26Add BLAST211

Proteomic databases

PaxDbiQ5FVI9

Expressioni

Gene expression databases

BgeeiENSRNOG00000011518
GenevisibleiQ5FVI9 RN

Interactioni

Subunit structurei

Interacts with HSF4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015725

Structurei

3D structure databases

ProteinModelPortaliQ5FVI9
SMRiQ5FVI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 206Tyrosine-protein phosphataseAdd BLAST146

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000233767
HOVERGENiHBG001524
InParanoidiQ5FVI9
KOiK14165
OMAiYLMIRQN
OrthoDBiEOG091G0249
PhylomeDBiQ5FVI9
TreeFamiTF105128

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020405 Atypical_DUSP_famA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01909 ADSPHPHTASEA
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPGNWLWAS MTFMARFSRS SSRSPVRTRG SLEEMPSVHH PFLNVFELER
60 70 80 90 100
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR
110 120 130 140 150
GTPEAYEGLG IRYLGVEAHD SPAFDMSVHF QTAADFIHRA LSQPGGKILV
160 170 180 190 200
HCAVGVSRSA TLVLAYLMLY HHFTLVEAIK KVKDHRGIIP NRGFLRQLLA
210
LDRRLRQGLE A
Length:211
Mass (Da):23,947
Last modified:March 1, 2005 - v1
Checksum:i0209F0B9DF23A542
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089954 mRNA Translation: AAH89954.1
RefSeqiNP_001012352.1, NM_001012352.1
XP_006253294.1, XM_006253232.3
XP_017455623.1, XM_017600134.1
UniGeneiRn.22231

Genome annotation databases

EnsembliENSRNOT00000015725; ENSRNOP00000015725; ENSRNOG00000011518
GeneIDi306527
KEGGirno:306527
UCSCiRGD:1310090 rat

Similar proteinsi

Entry informationi

Entry nameiDUS26_RAT
AccessioniPrimary (citable) accession number: Q5FVI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health