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Q5FVI9

- DUS26_RAT

UniProt

Q5FVI9 - DUS26_RAT

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Protein

Dual specificity protein phosphatase 26

Gene
Dusp26
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dusp26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 16

Organism-specific databases

RGDi1310090. Dusp26.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. mitochondrion Source: Ensembl
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292222Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ5FVI9.

Interactioni

Subunit structurei

Interacts with HSF4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5FVI9.
SMRiQ5FVI9. Positions 61-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 206146Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00550000074474.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ5FVI9.
KOiK14165.
OMAiMAFMSRF.
OrthoDBiEOG7CZK7N.
PhylomeDBiQ5FVI9.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVI9-1 [UniParc]FASTAAdd to Basket

« Hide

MCPGNWLWAS MTFMARFSRS SSRSPVRTRG SLEEMPSVHH PFLNVFELER    50
LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR 100
GTPEAYEGLG IRYLGVEAHD SPAFDMSVHF QTAADFIHRA LSQPGGKILV 150
HCAVGVSRSA TLVLAYLMLY HHFTLVEAIK KVKDHRGIIP NRGFLRQLLA 200
LDRRLRQGLE A 211
Length:211
Mass (Da):23,947
Last modified:March 1, 2005 - v1
Checksum:i0209F0B9DF23A542
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089954 mRNA. Translation: AAH89954.1.
RefSeqiNP_001012352.1. NM_001012352.1.
XP_006253294.1. XM_006253232.1.
UniGeneiRn.22231.

Genome annotation databases

EnsembliENSRNOT00000015725; ENSRNOP00000015725; ENSRNOG00000011518.
GeneIDi306527.
KEGGirno:306527.
UCSCiRGD:1310090. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC089954 mRNA. Translation: AAH89954.1 .
RefSeqi NP_001012352.1. NM_001012352.1.
XP_006253294.1. XM_006253232.1.
UniGenei Rn.22231.

3D structure databases

ProteinModelPortali Q5FVI9.
SMRi Q5FVI9. Positions 61-210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015725 ; ENSRNOP00000015725 ; ENSRNOG00000011518 .
GeneIDi 306527.
KEGGi rno:306527.
UCSCi RGD:1310090. rat.

Organism-specific databases

CTDi 78986.
RGDi 1310090. Dusp26.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00550000074474.
HOGENOMi HOG000233767.
HOVERGENi HBG001524.
InParanoidi Q5FVI9.
KOi K14165.
OMAi MAFMSRF.
OrthoDBi EOG7CZK7N.
PhylomeDBi Q5FVI9.
TreeFami TF105128.

Miscellaneous databases

NextBioi 656170.
PROi Q5FVI9.

Gene expression databases

Genevestigatori Q5FVI9.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiDUS26_RAT
AccessioniPrimary (citable) accession number: Q5FVI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi