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Q5FVI9

- DUS26_RAT

UniProt

Q5FVI9 - DUS26_RAT

Protein

Dual specificity protein phosphatase 26

Gene

Dusp26

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 26 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Dusp26
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi1310090. Dusp26.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. mitochondrion Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Dual specificity protein phosphatase 26PRO_0000292222Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ5FVI9.

    Interactioni

    Subunit structurei

    Interacts with HSF4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FVI9.
    SMRiQ5FVI9. Positions 61-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 206146Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00550000074474.
    HOGENOMiHOG000233767.
    HOVERGENiHBG001524.
    InParanoidiQ5FVI9.
    KOiK14165.
    OMAiMAFMSRF.
    OrthoDBiEOG7CZK7N.
    PhylomeDBiQ5FVI9.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FVI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCPGNWLWAS MTFMARFSRS SSRSPVRTRG SLEEMPSVHH PFLNVFELER    50
    LLYTGKTACN HADEVWPGLY LGDQDMANNR RELRRLGITH VLNASHSRWR 100
    GTPEAYEGLG IRYLGVEAHD SPAFDMSVHF QTAADFIHRA LSQPGGKILV 150
    HCAVGVSRSA TLVLAYLMLY HHFTLVEAIK KVKDHRGIIP NRGFLRQLLA 200
    LDRRLRQGLE A 211
    Length:211
    Mass (Da):23,947
    Last modified:March 1, 2005 - v1
    Checksum:i0209F0B9DF23A542
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089954 mRNA. Translation: AAH89954.1.
    RefSeqiNP_001012352.1. NM_001012352.1.
    XP_006253294.1. XM_006253232.1.
    UniGeneiRn.22231.

    Genome annotation databases

    EnsembliENSRNOT00000015725; ENSRNOP00000015725; ENSRNOG00000011518.
    GeneIDi306527.
    KEGGirno:306527.
    UCSCiRGD:1310090. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089954 mRNA. Translation: AAH89954.1 .
    RefSeqi NP_001012352.1. NM_001012352.1.
    XP_006253294.1. XM_006253232.1.
    UniGenei Rn.22231.

    3D structure databases

    ProteinModelPortali Q5FVI9.
    SMRi Q5FVI9. Positions 61-210.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015725 ; ENSRNOP00000015725 ; ENSRNOG00000011518 .
    GeneIDi 306527.
    KEGGi rno:306527.
    UCSCi RGD:1310090. rat.

    Organism-specific databases

    CTDi 78986.
    RGDi 1310090. Dusp26.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00550000074474.
    HOGENOMi HOG000233767.
    HOVERGENi HBG001524.
    InParanoidi Q5FVI9.
    KOi K14165.
    OMAi MAFMSRF.
    OrthoDBi EOG7CZK7N.
    PhylomeDBi Q5FVI9.
    TreeFami TF105128.

    Miscellaneous databases

    NextBioi 656170.
    PROi Q5FVI9.

    Gene expression databases

    Genevestigatori Q5FVI9.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiDUS26_RAT
    AccessioniPrimary (citable) accession number: Q5FVI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3