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Protein

Cell cycle exit and neuronal differentiation protein 1

Gene

Cend1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neuroblastoma cell differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle exit and neuronal differentiation protein 1
Gene namesi
Name:Cend1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1309401. Cend1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 125125CytoplasmicSequence analysisAdd
BLAST
Transmembranei126 – 14621Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini147 – 1493ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Cell cycle exit and neuronal differentiation protein 1PRO_0000245465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei95 – 951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVI4.
PRIDEiQ5FVI4.

PTM databases

iPTMnetiQ5FVI4.
PhosphoSiteiQ5FVI4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018448.
ExpressionAtlasiQ5FVI4. baseline.
GenevisibleiQ5FVI4. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi262868. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5FVI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CEND1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ5FVI4.
OMAiGPWPCEN.
OrthoDBiEOG091G11FY.
PhylomeDBiQ5FVI4.
TreeFamiTF336209.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q5FVI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRGKSASS PKPDTKVPQA TAEAKATPAA DGKAPLTKPV KKDAQAEKQE
60 70 80 90 100
QPAAPGPATT KKTPAKADPV LLNNHSNLKP APTVPAAPSS PDTTSEPKGP
110 120 130 140
GDGAEEDESN TGGRGPWPCE NLTPLLVAGG VAVATIALIL GVAFLARKK
Length:149
Mass (Da):15,043
Last modified:March 1, 2005 - v1
Checksum:i196D56164631009F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089963 mRNA. Translation: AAH89963.1.
RefSeqiNP_001014185.1. NM_001014163.1.
XP_003749055.1. XM_003749007.3.
XP_008772956.1. XM_008774734.1.
UniGeneiRn.64460.

Genome annotation databases

EnsembliENSRNOT00000024867; ENSRNOP00000024867; ENSRNOG00000018448.
ENSRNOT00000074016; ENSRNOP00000066509; ENSRNOG00000045680.
GeneIDi100911402.
361675.
KEGGirno:100911402.
rno:361675.
UCSCiRGD:1309401. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089963 mRNA. Translation: AAH89963.1.
RefSeqiNP_001014185.1. NM_001014163.1.
XP_003749055.1. XM_003749007.3.
XP_008772956.1. XM_008774734.1.
UniGeneiRn.64460.

3D structure databases

ProteinModelPortaliQ5FVI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi262868. 1 interaction.

PTM databases

iPTMnetiQ5FVI4.
PhosphoSiteiQ5FVI4.

Proteomic databases

PaxDbiQ5FVI4.
PRIDEiQ5FVI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024867; ENSRNOP00000024867; ENSRNOG00000018448.
ENSRNOT00000074016; ENSRNOP00000066509; ENSRNOG00000045680.
GeneIDi100911402.
361675.
KEGGirno:100911402.
rno:361675.
UCSCiRGD:1309401. rat.

Organism-specific databases

CTDi51286.
RGDi1309401. Cend1.

Phylogenomic databases

eggNOGiENOG410JCHN. Eukaryota.
ENOG41114ZP. LUCA.
GeneTreeiENSGT00390000012831.
HOGENOMiHOG000081828.
HOVERGENiHBG081082.
InParanoidiQ5FVI4.
OMAiGPWPCEN.
OrthoDBiEOG091G11FY.
PhylomeDBiQ5FVI4.
TreeFamiTF336209.

Miscellaneous databases

PROiQ5FVI4.

Gene expression databases

BgeeiENSRNOG00000018448.
ExpressionAtlasiQ5FVI4. baseline.
GenevisibleiQ5FVI4. RN.

Family and domain databases

InterProiIPR020162. Cend1.
[Graphical view]
PfamiPF15677. CEND1. 1 hit.
[Graphical view]
ProDomiPD079544. Cend1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiCEND_RAT
AccessioniPrimary (citable) accession number: Q5FVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.