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Protein

Regulator of G-protein signaling 7-binding protein

Gene

Rgs7bp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cypolasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 7-binding protein
Alternative name(s):
R7 family-binding protein
Gene namesi
Name:Rgs7bp
Synonyms:R7bp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309360. Rgs7bp.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell membrane By similarity; Lipid-anchor By similarity

  • Note: Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Regulator of G-protein signaling 7-binding proteinPRO_0000287597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi252 – 2521S-palmitoyl cysteineBy similarity
Lipidationi253 – 2531S-palmitoyl cysteineBy similarity

Post-translational modificationi

Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted into the nucleus.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ5FVH8.
PRIDEiQ5FVH8.

Expressioni

Gene expression databases

GenevisibleiQ5FVH8. RN.

Interactioni

Subunit structurei

Interacts with 'R7' family proteins RGS6, RGS7, RGS9 and RGS11. Component of some R7-Gbeta5 complex composed of some R7 protein (RGS6, RGS7, RGS9 or RGS11), Gbeta5 (GNB5) and RGS7BP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018058.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi242 – 2476Nuclear localization signalBy similarity

Domaini

The nuclear localization signal is both required for nuclear localization and palmitoylation.By similarity

Sequence similaritiesi

Belongs to the RGS7BP/RGS9BP family.Curated

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ5FVH8.
OMAiGSLQLHR.
OrthoDBiEOG741Z2Z.
PhylomeDBiQ5FVH8.
TreeFamiTF330985.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FVH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL
60 70 80 90 100
DDCKMLVQEF NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR
110 120 130 140 150
QAHQKLAAIS GPEDGEIHPE ICRLYIQLQC CLEMYTTEML KSICLLGSLQ
160 170 180 190 200
FHRKGKEASG GAKSLDSKIE ENAETPALED SLSSPLDSQQ QSWQVATDIE
210 220 230 240 250
NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPM VRRRKRRFFG

LCCLVSS
Length:257
Mass (Da):28,966
Last modified:March 1, 2005 - v1
Checksum:i43312921B56319E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089977 mRNA. Translation: AAH89977.1.
RefSeqiNP_001012347.1. NM_001012347.1.
UniGeneiRn.198108.

Genome annotation databases

GeneIDi294715.
KEGGirno:294715.
UCSCiRGD:1309360. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089977 mRNA. Translation: AAH89977.1.
RefSeqiNP_001012347.1. NM_001012347.1.
UniGeneiRn.198108.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018058.

Proteomic databases

PaxDbiQ5FVH8.
PRIDEiQ5FVH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294715.
KEGGirno:294715.
UCSCiRGD:1309360. rat.

Organism-specific databases

CTDi401190.
RGDi1309360. Rgs7bp.

Phylogenomic databases

eggNOGiENOG410IH1X. Eukaryota.
ENOG410YXJD. LUCA.
HOGENOMiHOG000154060.
HOVERGENiHBG104928.
InParanoidiQ5FVH8.
OMAiGSLQLHR.
OrthoDBiEOG741Z2Z.
PhylomeDBiQ5FVH8.
TreeFamiTF330985.

Miscellaneous databases

NextBioi638471.
PROiQ5FVH8.

Gene expression databases

GenevisibleiQ5FVH8. RN.

Family and domain databases

InterProiIPR026512. RGS7BP/RGS9BP.
[Graphical view]
PANTHERiPTHR21029. PTHR21029. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiR7BP_RAT
AccessioniPrimary (citable) accession number: Q5FVH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2005
Last modified: February 17, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.