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Protein

AKT-interacting protein

Gene

Aktip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AKT-interacting protein
Alternative name(s):
Fused toes protein homolog
Gene namesi
Name:Aktip
Synonyms:Fts
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1311170. Aktip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292AKT-interacting proteinPRO_0000379018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVH4.

PTM databases

PhosphoSiteiQ5FVH4.

Expressioni

Gene expression databases

GenevisibleiQ5FVH4. RN.

Interactioni

Subunit structurei

Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057588.

Structurei

3D structure databases

ProteinModelPortaliQ5FVH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0429. Eukaryota.
ENOG410ZQ9Z. LUCA.
GeneTreeiENSGT00390000010125.
HOGENOMiHOG000033885.
InParanoidiQ5FVH4.
OMAiFSPWNPA.
OrthoDBiEOG7QG45C.
PhylomeDBiQ5FVH4.
TreeFamiTF314386.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPLWSMSSG SVRKRAEGEE KTLAGDVKTS PPRSAPKKQL PSIPKNALPI
60 70 80 90 100
SKPTSPAPAA QSTNGTHASY GPFYLEYSLL AEFTMVVKQK LPGVYVQPSY
110 120 130 140 150
RSALVWFGVI FIRHGLYQDG VFKFTVYIPD NYPDGDCPRL LFDIPVFHPL
160 170 180 190 200
VDPTSGELDV KRAFAKWRRN HNHIWQVLMY ARRVFYKIDT TSPLNPEAAV
210 220 230 240 250
LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP WNPSVHDEAR
260 270 280 290
EKMLTQKKPD EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT
Length:292
Mass (Da):32,992
Last modified:March 1, 2005 - v1
Checksum:i9F07F873B69A15EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089985 mRNA. Translation: AAH89985.1.
RefSeqiNP_001011926.1. NM_001011926.1.
UniGeneiRn.220001.

Genome annotation databases

EnsembliENSRNOT00000060865; ENSRNOP00000057588; ENSRNOG00000011956.
GeneIDi291906.
KEGGirno:291906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089985 mRNA. Translation: AAH89985.1.
RefSeqiNP_001011926.1. NM_001011926.1.
UniGeneiRn.220001.

3D structure databases

ProteinModelPortaliQ5FVH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057588.

PTM databases

PhosphoSiteiQ5FVH4.

Proteomic databases

PaxDbiQ5FVH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000060865; ENSRNOP00000057588; ENSRNOG00000011956.
GeneIDi291906.
KEGGirno:291906.

Organism-specific databases

CTDi64400.
RGDi1311170. Aktip.

Phylogenomic databases

eggNOGiKOG0429. Eukaryota.
ENOG410ZQ9Z. LUCA.
GeneTreeiENSGT00390000010125.
HOGENOMiHOG000033885.
InParanoidiQ5FVH4.
OMAiFSPWNPA.
OrthoDBiEOG7QG45C.
PhylomeDBiQ5FVH4.
TreeFamiTF314386.

Miscellaneous databases

PROiQ5FVH4.

Gene expression databases

GenevisibleiQ5FVH4. RN.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAKTIP_RAT
AccessioniPrimary (citable) accession number: Q5FVH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2005
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.