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Protein

Complement C1q tumor necrosis factor-related protein 5

Gene

C1qtnf5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C1q tumor necrosis factor-related protein 5
Gene namesi
Name:C1qtnf5
Synonyms:Ctrp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1308802. C1qtnf5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15By similarityAdd BLAST15
ChainiPRO_000000353716 – 243Complement C1q tumor necrosis factor-related protein 5Add BLAST228

Proteomic databases

PaxDbiQ5FVH0.
PRIDEiQ5FVH0.

PTM databases

PhosphoSitePlusiQ5FVH0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007613.
GenevisibleiQ5FVH0. RN.

Interactioni

Subunit structurei

Homotrimer (via collagen-like domain). May form higher order oligomers by supercoiling of the trimers. May interact with ERFE (By similarity).By similarity

Protein-protein interaction databases

IntActiQ5FVH0. 1 interactor.
MINTiMINT-1794064.
STRINGi10116.ENSRNOP00000010127.

Structurei

3D structure databases

ProteinModelPortaliQ5FVH0.
SMRiQ5FVH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 95Collagen-likeAdd BLAST66
Domaini99 – 238C1qPROSITE-ProRule annotationAdd BLAST140

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IHSH. Eukaryota.
ENOG410YPYW. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ5FVH0.
OMAiINEQGHY.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ5FVH0.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLLALLLL GLASGSPPLD DNKIPSLCPG QPGLPGTPGH HGSQGLPGRD
60 70 80 90 100
GRDGRDGAPG APGEKGEGGR PGLPGPRGEP GPRGEAGPVG AIGPAGECSV
110 120 130 140 150
PPRSAFSAKR SESRVPPPAD TPLPFDRVLL NEQGHYDATT GKFTCQVPGV
160 170 180 190 200
YYFAVHATVY RASLQFDLVK NGQSIASFFQ FFGGWPKPAS LSGGAMVRLE
210 220 230 240
PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP VFA
Length:243
Mass (Da):25,334
Last modified:March 1, 2005 - v1
Checksum:i178AB5F39D52B041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089992 mRNA. Translation: AAH89992.1.
RefSeqiNP_001012123.1. NM_001012123.1.
XP_017451111.1. XM_017595622.1.
UniGeneiRn.99884.

Genome annotation databases

EnsembliENSRNOT00000010127; ENSRNOP00000010127; ENSRNOG00000007613.
GeneIDi315598.
KEGGirno:315598.
UCSCiRGD:1308802. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089992 mRNA. Translation: AAH89992.1.
RefSeqiNP_001012123.1. NM_001012123.1.
XP_017451111.1. XM_017595622.1.
UniGeneiRn.99884.

3D structure databases

ProteinModelPortaliQ5FVH0.
SMRiQ5FVH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5FVH0. 1 interactor.
MINTiMINT-1794064.
STRINGi10116.ENSRNOP00000010127.

PTM databases

PhosphoSitePlusiQ5FVH0.

Proteomic databases

PaxDbiQ5FVH0.
PRIDEiQ5FVH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010127; ENSRNOP00000010127; ENSRNOG00000007613.
GeneIDi315598.
KEGGirno:315598.
UCSCiRGD:1308802. rat.

Organism-specific databases

CTDi114902.
RGDi1308802. C1qtnf5.

Phylogenomic databases

eggNOGiENOG410IHSH. Eukaryota.
ENOG410YPYW. LUCA.
GeneTreeiENSGT00760000118830.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiQ5FVH0.
OMAiINEQGHY.
OrthoDBiEOG091G0L3Y.
PhylomeDBiQ5FVH0.
TreeFamiTF329591.

Miscellaneous databases

PROiQ5FVH0.

Gene expression databases

BgeeiENSRNOG00000007613.
GenevisibleiQ5FVH0. RN.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF01391. Collagen. 2 hits.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC1QT5_RAT
AccessioniPrimary (citable) accession number: Q5FVH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2005
Last modified: March 15, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.