Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich protein 5

Gene

Prr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 5
Alternative name(s):
Protein observed with Rictor-1
Short name:
Protor-1
Gene namesi
Name:Prr5By similarity
Synonyms:Protor1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307954. Prr5.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Proline-rich protein 5PRO_0000308164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531PhosphoserineBy similarity
Modified residuei373 – 3731PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVG6.

PTM databases

iPTMnetiQ5FVG6.
PhosphoSiteiQ5FVG6.

Expressioni

Gene expression databases

GenevisibleiQ5FVG6. RN.

Interactioni

Subunit structurei

Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (By similarity). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016679.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 9687Interaction with RICTORBy similarityAdd
BLAST
Regioni189 – 21931Interaction with RICTORBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the PROTOR family.Curated

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
HOVERGENiHBG067971.
InParanoidiQ5FVG6.
OMAiEYETEGM.
OrthoDBiEOG771278.
PhylomeDBiQ5FVG6.
TreeFamiTF314826.

Family and domain databases

InterProiIPR013745. Bit61/PRR5.
[Graphical view]
PfamiPF08539. HbrB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLRRLKFM SSPSLSDLGK REPGAAGADE RGTQQRRACA NATWNSIHNG
60 70 80 90 100
VIAVFQRKGL PDQELFILNE GVRQLLKTEL GSFFTEYLQN QLLTKGMVIL
110 120 130 140 150
RDKIRFYEGQ KLLDSLAETW DFFFSDVLPT LQAIFYPVQG KEPSVRQLAL
160 170 180 190 200
LHFRNTITLS VKLEDALARS HACVPPAIAQ MLLVLQGVHE SRGVTEDYLR
210 220 230 240 250
LETLIQKVVS PYLGTYGLYS NEGPCTHSCI LEKRFLRRSR SGDILAKNPV
260 270 280 290 300
VRSKSYNTPL LNPVAEHEAE GTASGGTSIR RHSVSEMTSC PEPQGFVDTP
310 320 330 340 350
DQGPSGTFRS SPSPHSGPCP SRLYPPAHSP EQGPDHGSPP TSSPETLVDQ
360 370 380
ILESVDSDSE GIFIDFGRGS RSSVSDFEAA GGRPSVV
Length:387
Mass (Da):42,540
Last modified:March 1, 2005 - v1
Checksum:iC99EAEF90A8B32C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090007 mRNA. Translation: AAH90007.1.
RefSeqiNP_001012121.1. NM_001012121.1.
UniGeneiRn.30314.

Genome annotation databases

GeneIDi315189.
KEGGirno:315189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090007 mRNA. Translation: AAH90007.1.
RefSeqiNP_001012121.1. NM_001012121.1.
UniGeneiRn.30314.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016679.

PTM databases

iPTMnetiQ5FVG6.
PhosphoSiteiQ5FVG6.

Proteomic databases

PaxDbiQ5FVG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi315189.
KEGGirno:315189.

Organism-specific databases

CTDi55615.
RGDi1307954. Prr5.

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
HOVERGENiHBG067971.
InParanoidiQ5FVG6.
OMAiEYETEGM.
OrthoDBiEOG771278.
PhylomeDBiQ5FVG6.
TreeFamiTF314826.

Miscellaneous databases

PROiQ5FVG6.

Gene expression databases

GenevisibleiQ5FVG6. RN.

Family and domain databases

InterProiIPR013745. Bit61/PRR5.
[Graphical view]
PfamiPF08539. HbrB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.

Entry informationi

Entry nameiPRR5_RAT
AccessioniPrimary (citable) accession number: Q5FVG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.